help button home button Endocrine Society Molecular Endocrinology ENDO 08 Sessions Library
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
This Article
Right arrow Full Text (PDF)
Right arrow Purchase Article
Right arrow View Shopping Cart
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow Request Copyright Permission
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Zhou, Z. X.
Right arrow Articles by Wilson, E. M.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Zhou, Z. X.
Right arrow Articles by Wilson, E. M.

Molecular Endocrinology, Vol 9, 208-218, Copyright © 1995 by Endocrine Society

ARTICLES

Specificity of ligand-dependent androgen receptor stabilization: receptor domain interactions influence ligand dissociation and receptor stability

ZX Zhou, MV Lane, JA Kemppainen, FS French and EM Wilson
Department of Pediatrics, University of North Carolina, Chapel Hill 27599, USA.

The molecular basis for the different physiological effects of testosterone (T) and dihydrotestosterone (DHT) was investigated using recombinantly expressed wild-type and mutant androgen receptor (AR). Rates of androgen dissociation from nuclear and cytoplasmic AR were compared with hormone- and concentration-dependent receptor degradation rates. T dissociates from AR 3 times faster than DHT or methyltrienolone (R1881) and is less effective in stabilizing the receptor. Analysis of AR deletion mutants and AR/glucocorticoid receptor chimeras indicates that the AR NH2-terminal domain has a specific role in stabilizing the receptor by slowing the rate of ligand dissociation and AR degradation. Amino acid mutations that abolish receptor dimerization, nuclear localization, or DNA-binding activity have no significant effect on androgen dissociation or AR degradation. A naturally occurring steroid-binding domain mutation (Val889 to Met) that causes androgen insensitivity, but does not alter equilibrium androgen binding affinity, lowered the androgen-binding capacity as a result of increased rates of androgen dissociation and AR degradation. Thus, AR stabilization and function require prolonged receptor occupancy with androgen, with a similar extent of stabilization observed at higher concentrations of faster dissociating androgens and lower concentrations of slower dissociating androgens. Retention of receptor-bound androgen is enhanced by an interaction between the AR NH2-terminal and steroid-binding domains. The ligand specificity and concentration dependence of receptor stabilization provide an explanation for physiological differences in the actions of T and DHT.


This article has been cited by other articles:


Home page
 Mol. Endocrinol.Home page
M. M. Centenera, J. M. Harris, W. D. Tilley, and L. M. Butler
Minireview: The Contribution of Different Androgen Receptor Domains to Receptor Dimerization and Signaling
Mol. Endocrinol., November 1, 2008; 22(11): 2373 - 2382.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Cell. Biol.Home page
S. Bai and E. M. Wilson
Epidermal Growth Factor-Dependent Phosphorylation and Ubiquitinylation of MAGE-11 Regulates Its Interaction with the Androgen Receptor
Mol. Cell. Biol., March 15, 2008; 28(6): 1947 - 1963.
[Abstract] [Full Text] [PDF]

Home page
 Mol Hum ReprodHome page
S. Bai, G. Grossman, L. Yuan, B. A. Lessey, F. S. French, S. L. Young, and E. M. Wilson
Hormone control and expression of androgen receptor coregulator MAGE-11 in human endometrium during the window of receptivity to embryo implantation
Mol. Hum. Reprod., February 1, 2008; 14(2): 107 - 116.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
S. Chouinard, O. Barbier, and A. Belanger
UDP-glucuronosyltransferase 2B15 (UGT2B15) and UGT2B17 Enzymes Are Major Determinants of the Androgen Response in Prostate Cancer LNCaP Cells
J. Biol. Chem., November 16, 2007; 282(46): 33466 - 33474.
[Abstract] [Full Text] [PDF]

Home page
 Molecular Cancer TherapeuticsHome page
E. A. Ariazi, A. Leitao, T. I. Oprea, B. Chen, T. Louis, A. M. Bertucci, C. G.N. Sharma, S. D. Gill, H. R. Kim, H. A. Shupp, et al.
Exemestane's 17-hydroxylated metabolite exerts biological effects as an androgen
Mol. Cancer Ther., November 1, 2007; 6(11): 2817 - 2827.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
E. B. Askew, R. T. Gampe Jr., T. B. Stanley, J. L. Faggart, and E. M. Wilson
Modulation of Androgen Receptor Activation Function 2 by Testosterone and Dihydrotestosterone
J. Biol. Chem., August 31, 2007; 282(35): 25801 - 25816.
[Abstract] [Full Text] [PDF]

Home page
 EndocrinologyHome page
T.-V. V. Nguyen, M. Yao, and C. J. Pike
Flutamide and Cyproterone Acetate Exert Agonist Effects: Induction of Androgen Receptor-Dependent Neuroprotection
Endocrinology, June 1, 2007; 148(6): 2936 - 2943.
[Abstract] [Full Text] [PDF]

Home page
 J EndocrinolHome page
S. J Meachem, S. Schlatt, S. M Ruwanpura, and P. G Stanton
The effect of testosterone, dihydrotestosterone and oestradiol on the re-initiation of spermatogenesis in the adult photoinhibited Djungarian hamster
J. Endocrinol., March 1, 2007; 192(3): 553 - 561.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Endocrinol. Metab.Home page
L. K. Potter, M. G. Zager, and H. A. Barton
Mathematical model for the androgenic regulation of the prostate in intact and castrated adult male rats
Am J Physiol Endocrinol Metab, November 1, 2006; 291(5): E952 - E964.
[Abstract] [Full Text] [PDF]

Home page
 Proc. Natl. Acad. Sci. USAHome page
S. Chen, Y. Xu, X. Yuan, G. J. Bubley, and S. P. Balk
Androgen receptor phosphorylation and stabilization in prostate cancer by cyclin-dependent kinase 1
PNAS, October 24, 2006; 103(43): 15969 - 15974.
[Abstract] [Full Text] [PDF]

Home page
 EndocrinologyHome page
M. Welsh, P. T. K. Saunders, N. I. Marchetti, and R. M. Sharpe
Androgen-Dependent Mechanisms of Wolffian Duct Development and Their Perturbation by Flutamide
Endocrinology, October 1, 2006; 147(10): 4820 - 4830.
[Abstract] [Full Text] [PDF]

Home page
 J Mol EndocrinolHome page
J Jaaskelainen, A Deeb, J W Schwabe, N P Mongan, H Martin, and I A Hughes
Human androgen receptor gene ligand-binding-domain mutations leading to disrupted interaction between the N- and C-terminal domains.
J. Mol. Endocrinol., April 1, 2006; 36(2): 361 - 368.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
B. He, R. T. Gampe Jr., A. T. Hnat, J. L. Faggart, J. T. Minges, F. S. French, and E. M. Wilson
Probing the Functional Link between Androgen Receptor Coactivator and Ligand-binding Sites in Prostate Cancer and Androgen Insensitivity
J. Biol. Chem., March 10, 2006; 281(10): 6648 - 6663.
[Abstract] [Full Text] [PDF]

Home page
 Nucleic Acids ResHome page
P. Servert, J. Garcia-Castro, V. Diaz, D. Lucas, M. A. Gonzalez, C. Martinez-A, and A. Bernad
Inducible model for {beta}-six-mediated site-specific recombination in mammalian cells
Nucleic Acids Res., January 3, 2006; 34(1): e1 - e1.
[Abstract] [Full Text] [PDF]

Home page
 Molecular Cancer TherapeuticsHome page
R. Ilagan, L. J. Zhang, J. Pottratz, K. Le, S. Salas, M. Iyer, L. Wu, S. S. Gambhir, and M. Carey
Imaging androgen receptor function during flutamide treatment in the LAPC9 xenograft model
Mol. Cancer Ther., November 1, 2005; 4(11): 1662 - 1669.
[Abstract] [Full Text] [PDF]

Home page
 EndocrinologyHome page
R.-S. Ge, Q. Dong, E.-m. Niu, C. M. Sottas, D. O. Hardy, J. F. Catterall, S. A. Latif, D. J. Morris, and M. P. Hardy
11{beta}-Hydroxysteroid Dehydrogenase 2 in Rat Leydig Cells: Its Role in Blunting Glucocorticoid Action at Physiological Levels of Substrate
Endocrinology, June 1, 2005; 146(6): 2657 - 2664.
[Abstract] [Full Text] [PDF]

Home page
 Cancer Res.Home page
D.E. Clark, T.M. Errington, J.A. Smith, H.F. Frierson Jr., M.J. Weber, and D.A. Lannigan
The Serine/Threonine Protein Kinase, p90 Ribosomal S6 Kinase, Is an Important Regulator of Prostate Cancer Cell Proliferation
Cancer Res., April 15, 2005; 65(8): 3108 - 3116.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
S. Vlahopoulos, W. E. Zimmer, G. Jenster, N. S. Belaguli, S. P. Balk, A. O. Brinkmann, R. B. Lanz, V. C. Zoumpourlis, and R. J. Schwartz
Recruitment of the Androgen Receptor via Serum Response Factor Facilitates Expression of a Myogenic Gene
J. Biol. Chem., March 4, 2005; 280(9): 7786 - 7792.
[Abstract] [Full Text] [PDF]

Home page
 J AndrolHome page
M. Yamamoto, A. Narita, M. Kagohata, M. Shirai, F. Akahori, and K. Arishima
Effects of Maternal Exposure to 3,3',4,4',5-Pentachlorobiphenyl (PCB126) or 3,3',4,4',5,5'-Hexachlorobiphenyl (PCB169) on Testicular Steroidogenesis and Spermatogenesis in Male Offspring Rats
J Androl, March 1, 2005; 26(2): 205 - 214.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Cell. Biol.Home page
S. Bai, B. He, and E. M. Wilson
Melanoma Antigen Gene Protein MAGE-11 Regulates Androgen Receptor Function by Modulating the Interdomain Interaction
Mol. Cell. Biol., February 15, 2005; 25(4): 1238 - 1257.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Endocrinol.Home page
C.-L. Hsu, Y.-L. Chen, H.-J. Ting, W.-J. Lin, Z. Yang, Y. Zhang, L. Wang, C.-T. Wu, H.-C. Chang, S. Yeh, et al.
Androgen Receptor (AR) NH2- and COOH-Terminal Interactions Result in the Differential Influences on the AR-Mediated Transactivation and Cell Growth
Mol. Endocrinol., February 1, 2005; 19(2): 350 - 361.
[Abstract] [Full Text] [PDF]

Home page
 J. Clin. Endocrinol. Metab.Home page
A. Umar, C. A. Berrevoets, N. M. Van, M. van Leeuwen, M. Verbiest, W. J. Kleijer, D. Dooijes, J. A. Grootegoed, S. L. S. Drop, and A. O. Brinkmann
Functional Analysis of a Novel Androgen Receptor Mutation, Q902K, in an Individual with Partial Androgen Insensitivity
J. Clin. Endocrinol. Metab., January 1, 2005; 90(1): 507 - 515.
[Abstract] [Full Text] [PDF]

Home page
 Toxicol SciHome page
E. Sonneveld, H. J. Jansen, J. A. C. Riteco, A. Brouwer, and B. van der Burg
Development of Androgen- and Estrogen-Responsive Bioassays, Members of a Panel of Human Cell Line-Based Highly Selective Steroid-Responsive Bioassays
Toxicol. Sci., January 1, 2005; 83(1): 136 - 148.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Endocrinol. Metab.Home page
S. E. Borst, J. H. Lee, and C. F. Conover
Inhibition of 5{alpha}-reductase blocks prostate effects of testosterone without blocking anabolic effects
Am J Physiol Endocrinol Metab, January 1, 2005; 288(1): E222 - E227.
[Abstract] [Full Text] [PDF]

Home page
 J. Clin. Endocrinol. Metab.Home page
I. U. Agoulnik, X.-W. Tong, D.-C. Fischer, K. Korner, N. E. Atkinson, D. P. Edwards, D. R. Headon, N. L. Weigel, and D. G. Kieback
A Germline Variation in the Progesterone Receptor Gene Increases Transcriptional Activity and May Modify Ovarian Cancer Risk
J. Clin. Endocrinol. Metab., December 1, 2004; 89(12): 6340 - 6347.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Endocrinol.Home page
H.-K. Lin, Y.-C. Hu, D. K. Lee, and C. Chang
Regulation of Androgen Receptor Signaling by PTEN (Phosphatase and Tensin Homolog Deleted on Chromosome 10) Tumor Suppressor through Distinct Mechanisms in Prostate Cancer Cells
Mol. Endocrinol., October 1, 2004; 18(10): 2409 - 2423.
[Abstract] [Full Text] [PDF]

Home page
 Biol. Reprod.Home page
C. M. Hill, M. D. Anway, B. R. Zirkin, and T. R. Brown
Intratesticular Androgen Levels, Androgen Receptor Localization, and Androgen Receptor Expression in Adult Rat Sertoli Cells
Biol Reprod, October 1, 2004; 71(4): 1348 - 1358.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Endocrinol.Home page
H. J. Dubbink, R. Hersmus, C. S. Verma, H. A. G. M. van der Korput, C. A. Berrevoets, J. van Tol, A. C. J. Ziel-van der Made, A. O. Brinkmann, A. C. W. Pike, and J. Trapman
Distinct Recognition Modes of FXXLF and LXXLL Motifs by the Androgen Receptor
Mol. Endocrinol., September 1, 2004; 18(9): 2132 - 2150.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
B. He, S. Bai, A. T. Hnat, R. I. Kalman, J. T. Minges, C. Patterson, and E. M. Wilson
An Androgen Receptor NH2-terminal Conserved Motif Interacts with the COOH Terminus of the Hsp70-interacting Protein (CHIP)
J. Biol. Chem., July 16, 2004; 279(29): 30643 - 30653.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Cell. Biol.Home page
Y. Zhang, Y. Yang, S. Yeh, and C. Chang
ARA67/PAT1 Functions as a Repressor To Suppress Androgen Receptor Transactivation
Mol. Cell. Biol., February 1, 2004; 24(3): 1044 - 1057.
[Abstract] [Full Text] [PDF]

Home page
 EndocrinologyHome page
C. Woodham, L. Birch, and G. S. Prins
Neonatal Estrogen Down-Regulates Prostatic Androgen Receptor through a Proteosome-Mediated Protein Degradation Pathway
Endocrinology, November 1, 2003; 144(11): 4841 - 4850.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Endocrinol.Home page
A. Warnmark, E. Treuter, A. P. H. Wright, and J.-A. Gustafsson
Activation Functions 1 and 2 of Nuclear Receptors: Molecular Strategies for Transcriptional Activation
Mol. Endocrinol., October 1, 2003; 17(10): 1901 - 1909.
[Abstract] [Full Text] [PDF]

Home page
 J. Clin. Endocrinol. Metab.Home page
D. K. Lee and C. Chang
Expression and Degradation of Androgen Receptor: Mechanism and Clinical Implication
J. Clin. Endocrinol. Metab., September 1, 2003; 88(9): 4043 - 4054.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Endocrinol.Home page
A. J. James, I. U. Agoulnik, J. M. Harris, G. Buchanan, W. D. Tilley, M. Marcelli, D. J. Lamb, and N. L. Weigel
A Novel Androgen Receptor Mutant, A748T, Exhibits Hormone Concentration-Dependent Defects in Nuclear Accumulation and Activity Despite Normal Hormone-Binding Affinity
Mol. Endocrinol., December 1, 2002; 16(12): 2692 - 2705.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
T. Ueda, N. R. Mawji, N. Bruchovsky, and M. D. Sadar
Ligand-independent Activation of the Androgen Receptor by Interleukin-6 and the Role of Steroid Receptor Coactivator-1 in Prostate Cancer Cells
J. Biol. Chem., October 4, 2002; 277(41): 38087 - 38094.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
T. H. Thin, E. Kim, S. Yeh, E. R. Sampson, Y.-T. Chen, L. L. Collins, R. Basavappa, and C. Chang
Mutations in the Helix 3 Region of the Androgen Receptor Abrogate ARA70 Promotion of 17beta -Estradiol-induced Androgen Receptor Transactivation
J. Biol. Chem., September 20, 2002; 277(39): 36499 - 36508.
[Abstract] [Full Text] [PDF]

Home page
 J. Clin. Endocrinol. Metab.Home page
S. Rosa, A. Biason-Lauber, N. P. Mongan, F. Navratil, and E. J. Schoenle
Complete Androgen Insensitivity Syndrome Caused by a Novel Mutation in the Ligand-Binding Domain of the Androgen Receptor: Functional Characterization
J. Clin. Endocrinol. Metab., September 1, 2002; 87(9): 4378 - 4382.
[Abstract] [Full Text] [PDF]

Home page
 EndocrinologyHome page
G. Shetty, G. Wilson, M. P. Hardy, E. Niu, I. Huhtaniemi, and M. L. Meistrich
Inhibition of Recovery of Spermatogenesis in Irradiated Rats by Different Androgens
Endocrinology, September 1, 2002; 143(9): 3385 - 3396.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
E. D. Martinez and M. Danielsen
Loss of Androgen Receptor Transcriptional Activity at the G1/S Transition
J. Biol. Chem., August 9, 2002; 277(33): 29719 - 29729.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
B. He, L. W. Lee, J. T. Minges, and E. M. Wilson
Dependence of Selective Gene Activation on the Androgen Receptor NH2- and COOH-terminal Interaction
J. Biol. Chem., July 5, 2002; 277(28): 25631 - 25639.
[Abstract] [Full Text] [PDF]

Home page
 J. Clin. Endocrinol. Metab.Home page
A. Narula, Y.-Q. Gu, L. O'Donnell, P. G. Stanton, D. M. Robertson, R. I. McLachlan, and W. J. Bremner
Variability in Sperm Suppression during Testosterone Administration to Adult Monkeys Is Related to Follicle Stimulating Hormone Suppression and Not to Intratesticular Androgens
J. Clin. Endocrinol. Metab., July 1, 2002; 87(7): 3399 - 3406.
[Abstract] [Full Text] [PDF]

Home page
 JCOHome page
E. P. Gelmann
Molecular Biology of the Androgen Receptor
J. Clin. Oncol., July 1, 2002; 20(13): 3001 - 3015.
[Abstract] [Full Text] [PDF]

Home page
 Endocr. Rev.Home page
C. A. Heinlein and C. Chang
Androgen Receptor (AR) Coregulators: An Overview
Endocr. Rev., April 1, 2002; 23(2): 175 - 200.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
B. He, J. T. Minges, L. W. Lee, and E. M. Wilson
The FXXLF Motif Mediates Androgen Receptor-specific Interactions with Coregulators
J. Biol. Chem., March 15, 2002; 277(12): 10226 - 10235.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Pathol.Home page
D. Kim, C. W. Gregory, F. S. French, G. J. Smith, and J. L. Mohler
Androgen Receptor Expression and Cellular Proliferation During Transition from Androgen-Dependent to Recurrent Growth after Castration in the CWR22 Prostate Cancer Xenograft
Am. J. Pathol., January 1, 2002; 160(1): 219 - 226.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
X. Yuan, M. L. Lu, T. Li, and S. P. Balk
SRY Interacts with and Negatively Regulates Androgen Receptor Transcriptional Activity
J. Biol. Chem., November 30, 2001; 276(49): 46647 - 46654.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
B. He, N. T. Bowen, J. T. Minges, and E. M. Wilson
Androgen-induced NH2- and COOH-terminal Interaction Inhibits p160 Coactivator Recruitment by Activation Function 2
J. Biol. Chem., November 2, 2001; 276(45): 42293 - 42301.
[Abstract] [Full Text] [PDF]

Home page
 J. Clin. Endocrinol. Metab.Home page
A. L. M. Boehmer, A. O. Brinkmann, R. M. Nijman, M. C. T. Verleun-Mooijman, P. de Ruiter, M. F. Niermeijer, and S. L. S. Drop
Phenotypic Variation in a Family with Partial Androgen Insensitivity Syndrome Explained by Differences in 5{{alpha}} Dihydrotestosterone Availability
J. Clin. Endocrinol. Metab., March 1, 2001; 86(3): 1240 - 1246.
[Abstract] [Full Text]

Home page
 EndocrinologyHome page
J. M. Grad, L. S. Lyons, D. M. Robins, and K. L. Burnstein
The Androgen Receptor (AR) Amino-Terminus Imposes Androgen-Specific Regulation of AR Gene Expression via an Exonic Enhancer
Endocrinology, March 1, 2001; 142(3): 1107 - 1116.
[Abstract] [Full Text] [PDF]

Home page
 Endocr. Rev.Home page
D. Deplewski and R. L. Rosenfield
Role of Hormones in Pilosebaceous Unit Development
Endocr. Rev., August 1, 2000; 21(4): 363 - 392.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Endocrinol.Home page
R. K. Tyagi, Y. Lavrovsky, S. C. Ahn, C. S. Song, B. Chatterjee, and A. K. Roy
Dynamics of Intracellular Movement and Nucleocytoplasmic Recycling of the Ligand-Activated Androgen Receptor in Living Cells
Mol. Endocrinol., August 1, 2000; 14(8): 1162 - 1174.
[Abstract] [Full Text]

Home page
 Mol. Endocrinol.Home page
C. Hellal-Levy, J. Fagart, A. Souque, J.-M. Wurtz, D. Moras, and M.-E. Rafestin-Oblin
Crucial Role of the H11-H12 Loop in Stabilizing the Active Conformation of the Human Mineralocorticoid Receptor
Mol. Endocrinol., August 1, 2000; 14(8): 1210 - 1221.
[Abstract] [Full Text]

Home page
 Toxicol SciHome page
T. J. Schrader and G. M. Cooke
Examination of Selected Food Additives and Organochlorine Food Contaminants for Androgenic Activity in Vitro
Toxicol. Sci., February 1, 2000; 53(2): 278 - 288.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
B. He, J. A. Kemppainen, J. J. Voegel, H. Gronemeyer, and E. M. Wilson
Activation Function 2 in the Human Androgen Receptor Ligand Binding Domain Mediates Interdomain Communication with the NH2-terminal Domain
J. Biol. Chem., December 24, 1999; 274(52): 37219 - 37225.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Cell. Biol.Home page
C. L. Bevan, S. Hoare, F. Claessens, D. M. Heery, and M. G. Parker
The AF1 and AF2 Domains of the Androgen Receptor Interact with Distinct Regions of SRC1
Mol. Cell. Biol., December 1, 1999; 19(12): 8383 - 8392.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Endocrinol.Home page
L. V. Nazareth, D. L. Stenoien, W. E. Bingman III, A. J. James, C. Wu, Y. Zhang, D. P. Edwards, M. Mancini, M. Marcelli, D. J. Lamb, et al.
A C619Y Mutation in the Human Androgen Receptor Causes Inactivation and Mislocalization of the Receptor with Concomitant Sequestration of SRC-1 (Steroid Receptor Coactivator 1)
Mol. Endocrinol., December 1, 1999; 13(12): 2065 - 2075.
[Abstract] [Full Text]

Home page
 Mol. Endocrinol.Home page
J. M. Grad, J. Le Dai, S. Wu, and K. L. Burnstein
Multiple Androgen Response Elements and a Myc Consensus Site in the Androgen Receptor (AR) Coding Region Are Involved in Androgen-Mediated Up-Regulation of AR Messenger RNA
Mol. Endocrinol., November 1, 1999; 13(11): 1896 - 1911.
[Abstract] [Full Text]

Home page
 EndocrinologyHome page
A. S. Wright, R. C. Douglas, L. N. Thomas, C. B. Lazier, and R. S. Rittmaster
Androgen-Induced Regrowth in the Castrated Rat Ventral Prostate: Role of 5{alpha}-Reductase
Endocrinology, October 1, 1999; 140(10): 4509 - 4515.
[Abstract] [Full Text]

Home page
 EndocrinologyHome page
B. B. Yeap, R. G. Krueger, and P. J. Leedman
Differential Posttranscriptional Regulation of Androgen Receptor Gene Expression by Androgen in Prostate and Breast Cancer Cells
Endocrinology, July 1, 1999; 140(7): 3282 - 3291.
[Abstract] [Full Text]

Home page
 J. Biol. Chem.Home page
S. Roux, B. Terouanne, B. Couette, M.-E. Rafestin-Oblin, and J.-C. Nicolas
Conformational Change in the Human Glucocorticoid Receptor Induced by Ligand Binding Is Altered by Mutation of Isoleucine 747 by a Threonine
J. Biol. Chem., April 9, 1999; 274(15): 10059 - 10065.
[Abstract] [Full Text] [PDF]

Home page
 EndocrinologyHome page
S. Zhang, M.-L. Hsieh, W. Zhu, G. G. Klee, D. J. Tindall, and C. Y. F. Young
Interactive Effects of Triiodothyronine and Androgens on Prostate Cell Growth and Gene Expression
Endocrinology, April 1, 1999; 140(4): 1665 - 1671.