help button home button Endocrine Society Molecular Endocrinology ENDO 08 Sessions Library
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
This Article
Right arrow Full Text (PDF)
Right arrow Purchase Article
Right arrow View Shopping Cart
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow Request Copyright Permission
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Caldenhoven, E.
Right arrow Articles by Van der Saag, P. T.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Caldenhoven, E.
Right arrow Articles by Van der Saag, P. T.

Molecular Endocrinology, Vol 9, 401-412, Copyright © 1995 by Endocrine Society

ARTICLES

Negative cross-talk between RelA and the glucocorticoid receptor: a possible mechanism for the antiinflammatory action of glucocorticoids

E Caldenhoven, J Liden, S Wissink, A Van de Stolpe, J Raaijmakers, L Koenderman, S Okret, JA Gustafsson and PT Van der Saag
Hubrecht Laboratory, Netherlands Institute for Developmental Biology, Utrecht.

Glucocorticoids are efficient antiinflammatory agents, and their effects include transcriptional repression of several cytokines and adhesion molecules. Whereas glucocorticoids down-regulate the expression of genes relevant during inflammation, nuclear factor (NF)- kappa B/Rel proteins function as important positive regulators of these genes. The expression of intercellular adhesion molecule-1 (ICAM-1), which plays an essential role in recruitment and migration of leukocytes to sites of inflammation, is also down-regulated by glucocorticoids. We found that a functional NF-kappa B site in the ICAM- 1 promoter, which can be activated by either 12-O-tetradecanoylphorbol- 13-acetate or tumor necrosis factor-alpha (TNF alpha), is also the target for glucocorticoids. In this report we present evidence that the ligand-activated glucocorticoid receptor (GR) is able to repress RelA- mediated activation of the ICAM-1 NF-kappa B site. Conversely, transcriptional activation by GR via a glucocorticoid response element is specifically repressed by RelA, but not by other NF-kappa B/Rel family members. Mutational analysis of GR demonstrates that the DNA binding domain and the ligand binding domain are required for the functional repression of NF-kappa B activation. Despite the importance of the DNA binding domain, we found that the transcriptional repression of NF-kappa B, mediated by GR, is not caused by binding of GR to the ICAM-1 NF-kappa B element, but by a physical interaction between the GR and RelA protein. The repressive effect of GR on NF-kappa B-mediated activation was not shared by other steroid/thyroid receptors. Only the progesterone receptor, which belongs to the same subfamily as GR and which possesses high homology with GR, was able to repress NF-kappa B- mediated transcription. These studies highlight a possible molecular mechanism that can explain the antiinflammatory effects of glucocorticoid treatment during inflammation.


This article has been cited by other articles:


Home page
 Reproductive SciencesHome page
O. Guzeloglu-Kayisli, G. Halis, S. Taskiran, U. A. Kayisli, and A. Arici
DNA-Binding Ability of NF-{kappa}B is Affected Differently by ER{alpha} and ER{beta} and Its Activation Results in Inhibition of Estrogen Responsiveness
Reproductive Sciences, May 1, 2008; 15(5): 493 - 505.
[Abstract] [PDF]

Home page
 J BiochemHome page
S. Ogawa, M. Satake, and K. Ikuta
Physical and Functional Interactions between STAT5 and Runx Transcription Factors
J. Biochem., May 1, 2008; 143(5): 695 - 709.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Cell. ProteomicsHome page
L. M. Miller Jenkins, S. J. Mazur, M. Rossi, O. Gaidarenko, Y. Xu, and E. Appella
Quantitative Proteomics Analysis of the Effects of Ionizing Radiation in Wild Type and p53K317R Knock-in Mouse Thymocytes
Mol. Cell. Proteomics, April 1, 2008; 7(4): 716 - 727.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Cell Mol. Bio.Home page
O. Tliba, G. Damera, A. Banerjee, S. Gu, H. Baidouri, S. Keslacy, and Y. Amrani
Cytokines Induce an Early Steroid Resistance in Airway Smooth Muscle Cells: Novel Role of Interferon Regulatory Factor-1
Am. J. Respir. Cell Mol. Biol., April 1, 2008; 38(4): 463 - 472.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Pharmacol.Home page
R. Newton and N. S. Holden
Separating Transrepression and Transactivation: A Distressing Divorce for the Glucocorticoid Receptor?
Mol. Pharmacol., October 1, 2007; 72(4): 799 - 809.
[Abstract] [Full Text] [PDF]

Home page
 FASEB J.Home page
A. C. Liberman, D. Refojo, J. Druker, M. Toscano, T. Rein, F. Holsboer, and E. Arzt
The activated glucocorticoid receptor inhibits the transcription factor T-bet by direct protein-protein interaction
FASEB J, April 1, 2007; 21(4): 1177 - 1188.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
O. Stojadinovic, B. Lee, C. Vouthounis, S. Vukelic, I. Pastar, M. Blumenberg, H. Brem, and M. Tomic-Canic
Novel Genomic Effects of Glucocorticoids in Epidermal Keratinocytes: INHIBITION OF APOPTOSIS, INTERFERON-{gamma} PATHWAY, AND WOUND HEALING ALONG WITH PROMOTION OF TERMINAL DIFFERENTIATION
J. Biol. Chem., February 9, 2007; 282(6): 4021 - 4034.
[Abstract] [Full Text] [PDF]

Home page
 Adv. Physiol. Educ.Home page
E. Dale, M. Davis, and D. L. Faustman
A role for transcription factor NF-{kappa}B in autoimmunity: possible interactions of genes, sex, and the immune response
Advan Physiol Educ, December 1, 2006; 30(4): 152 - 158.
[Abstract] [Full Text] [PDF]

Home page
 Pharmacol. Rev.Home page
N. Z. Lu, S. E. Wardell, K. L. Burnstein, D. Defranco, P. J. Fuller, V. Giguere, R. B. Hochberg, L. McKay, J.-M. Renoir, N. L. Weigel, et al.
International Union of Pharmacology. LXV. The Pharmacology and Classification of the Nuclear Receptor Superfamily: Glucocorticoid, Mineralocorticoid, Progesterone, and Androgen Receptors
Pharmacol. Rev., December 1, 2006; 58(4): 782 - 797.
[Full Text] [PDF]

Home page
 Proc. Natl. Acad. Sci. USAHome page
K. De Bosscher, W. V. Berghe, I. M. E. Beck, W. Van Molle, N. Hennuyer, J. Hapgood, C. Libert, B. Staels, A. Louw, and G. Haegeman
A fully dissociated compound of plant origin for inflammatory gene repression
PNAS, November 1, 2005; 102(44): 15827 - 15832.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Crit. Care Med.Home page
C. Desmet, P. Gosset, E. Henry, V. Garze, P. Faisca, N. Vos, F. Jaspar, D. Melotte, B. Lambrecht, D. Desmecht, et al.
Treatment of Experimental Asthma by Decoy-mediated Local Inhibition of Activator Protein-1
Am. J. Respir. Crit. Care Med., September 15, 2005; 172(6): 671 - 678.
[Abstract] [Full Text] [PDF]

Home page
 EndocrinologyHome page
Y. S. Kim, S.-W. Jang, H. J. Sung, H. J. Lee, I. S. Kim, D. S. Na, and J. Ko
Role of 14-3-3{eta} as a Positive Regulator of the Glucocorticoid Receptor Transcriptional Activation
Endocrinology, July 1, 2005; 146(7): 3133 - 3140.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Endocrinol.Home page
M. J. M. Schaaf, L. J. Lewis-Tuffin, and J. A. Cidlowski
Ligand-Selective Targeting of the Glucocorticoid Receptor to Nuclear Subdomains Is Associated with Decreased Receptor Mobility
Mol. Endocrinol., June 1, 2005; 19(6): 1501 - 1515.
[Abstract] [Full Text] [PDF]

Home page
 Endocr. Rev.Home page
J. Rosen and J. N. Miner
The Search for Safer Glucocorticoid Receptor Ligands
Endocr. Rev., May 1, 2005; 26(3): 452 - 464.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Endocrinol.Home page
N. Yoshikawa, K. Yamamoto, N. Shimizu, S. Yamada, C. Morimoto, and H. Tanaka
The Distinct Agonistic Properties of the Phenylpyrazolosteroid Cortivazol Reveal Interdomain Communication within the Glucocorticoid Receptor
Mol. Endocrinol., May 1, 2005; 19(5): 1110 - 1124.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Pharmacol.Home page
A. Ialenti, G. Grassia, P. Di Meglio, P. Maffia, M. Di Rosa, and A. Ianaro
Mechanism of the Anti-Inflammatory Effect of Thiazolidinediones: Relationship with the Glucocorticoid Pathway
Mol. Pharmacol., May 1, 2005; 67(5): 1620 - 1628.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Endocrinol.Home page
C. Martens, S. Bilodeau, M. Maira, Y. Gauthier, and J. Drouin
Protein-Protein Interactions and Transcriptional Antagonism between the Subfamily of NGFI-B/Nur77 Orphan Nuclear Receptors and Glucocorticoid Receptor
Mol. Endocrinol., April 1, 2005; 19(4): 885 - 897.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Pharmacol.Home page
L.-G. Bladh, J. Liden, K. Dahlman-Wright, M. Reimers, S. Nilsson, and S. Okret
Identification of Endogenous Glucocorticoid Repressed Genes Differentially Regulated by a Glucocorticoid Receptor Mutant Able to Separate between Nuclear Factor-{kappa}B and Activator Protein-1 Repression
Mol. Pharmacol., March 1, 2005; 67(3): 815 - 826.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
H. Garside, A. Stevens, S. Farrow, C. Normand, B. Houle, A. Berry, B. Maschera, and D. Ray
Glucocorticoid Ligands Specify Different Interactions with NF-{kappa}B by Allosteric Effects on the Glucocorticoid Receptor DNA Binding Domain
J. Biol. Chem., November 26, 2004; 279(48): 50050 - 50059.
[Abstract] [Full Text] [PDF]

Home page
 Clin. Cancer Res.Home page
P. A. Robe, M. Bentires-Alj, M. Bonif, B. Rogister, M. Deprez, H. Haddada, M.-T. N. Khac, O. Jolois, K. Erkmen, M.-P. Merville, et al.
In vitro and In vivo Activity of the Nuclear Factor-{kappa}B Inhibitor Sulfasalazine in Human Glioblastomas
Clin. Cancer Res., August 15, 2004; 10(16): 5595 - 5603.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
R. Cunard, Y. Eto, J. T. Muljadi, C. K. Glass, C. J. Kelly, and M. Ricote
Repression of IFN-{gamma} Expression by Peroxisome Proliferator-Activated Receptor {gamma}
J. Immunol., June 15, 2004; 172(12): 7530 - 7536.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Endocrinol.Home page
M. U. De Martino, N. Bhattachryya, S. Alesci, T. Ichijo, G. P. Chrousos, and T. Kino
The Glucocorticoid Receptor and the Orphan Nuclear Receptor Chicken Ovalbumin Upstream Promoter-Transcription Factor II Interact with and Mutually Affect Each Other's Transcriptional Activities: Implications for Intermediary Metabolism
Mol. Endocrinol., April 1, 2004; 18(4): 820 - 833.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Crit. Care Med.Home page
R. Gagliardo, P. Chanez, M. Mathieu, A. Bruno, G. Costanzo, C. Gougat, I. Vachier, J. Bousquet, G. Bonsignore, and A. M. Vignola
Persistent Activation of Nuclear Factor-{kappa}B Signaling Pathway in Severe Uncontrolled Asthma
Am. J. Respir. Crit. Care Med., November 15, 2003; 168(10): 1190 - 1198.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
G. Li, S. Wang, and T. D. Gelehrter
Identification of Glucocorticoid Receptor Domains Involved in Transrepression of Transforming Growth Factor-{beta} Action
J. Biol. Chem., October 24, 2003; 278(43): 41779 - 41788.
[Abstract] [Full Text] [PDF]

Home page
 Endocr. Rev.Home page
K. De Bosscher, W. Vanden Berghe, and G. Haegeman
The Interplay between the Glucocorticoid Receptor and Nuclear Factor-{kappa}B or Activator Protein-1: Molecular Mechanisms for Gene Repression
Endocr. Rev., August 1, 2003; 24(4): 488 - 522.
[Abstract] [Full Text] [PDF]

Home page
 J. Cell Sci.Home page
G. Nelson, G. J. C. Wilde, D. G. Spiller, S. M. Kennedy, D. W. Ray, E. Sullivan, J. F. Unitt, and M. R. H. White
NF-{kappa}B signalling is inhibited by glucocorticoid receptor and STAT6 via distinct mechanisms
J. Cell Sci., June 15, 2003; 116(12): 2495 - 2503.
[Abstract] [Full Text] [PDF]

Home page
 J. Clin. Endocrinol. Metab.Home page
F. A. Patel, J. W. Funder, and J. R. G. Challis
Mechanism of Cortisol/Progesterone Antagonism in the Regulation of 15-Hydroxyprostaglandin Dehydrogenase Activity and Messenger Ribonucleic Acid Levels in Human Chorion and Placental Trophoblast Cells at Term
J. Clin. Endocrinol. Metab., June 1, 2003; 88(6): 2922 - 2933.
[Abstract] [Full Text] [PDF]

Home page
 Int ImmunolHome page
N. Tosa, M. Murakami, W. Y. Jia, M. Yokoyama, T. Masunaga, C. Iwabuchi, M. Inobe, K. Iwabuchi, T. Miyazaki, K. Onoe, et al.
Critical function of T cell death-associated gene 8 in glucocorticoid-induced thymocyte apoptosis
Int. Immunol., June 1, 2003; 15(6): 741 - 749.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Cell. Biol.Home page
M. J. M. Schaaf and J. A. Cidlowski
Molecular Determinants of Glucocorticoid Receptor Mobility in Living Cells: the Importance of Ligand Affinity
Mol. Cell. Biol., March 15, 2003; 23(6): 1922 - 1934.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
M. B. Boffa, J. D. Hamill, D. Maret, D. Brown, M. L. Scott, M. E. Nesheim, and M. L. Koschinsky
Acute Phase Mediators Modulate Thrombin-activable Fibrinolysis Inhibitor (TAFI) Gene Expression in HepG2 Cells
J. Biol. Chem., March 7, 2003; 278(11): 9250 - 9257.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
S. de Haij, I. M. Adcock, A. C. Bakker, S. J. P. Gobin, M. R. Daha, and C. van Kooten
Steroid Responsiveness of Renal Epithelial Cells. DISSOCIATION OF TRANSREPRESSION AND TRANSACTIVATION
J. Biol. Chem., February 7, 2003; 278(7): 5091 - 5098.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
T. Kino and G. P. Chrousos
Tumor Necrosis Factor alpha Receptor- and Fas-associated FLASH Inhibit Transcriptional Activity of the Glucocorticoid Receptor by Binding to and Interfering with Its Interaction with p160 Type Nuclear Receptor Coactivators
J. Biol. Chem., January 24, 2003; 278(5): 3023 - 3029.
[Abstract] [Full Text] [PDF]

Home page
 Proc. Natl. Acad. Sci. USAHome page
S. Fiorucci, E. Antonelli, E. Distrutti, P. Del Soldato, R. J. Flower, M. J. P. Clark, A. Morelli, M. Perretti, and L. J. Ignarro
NCX-1015, a nitric-oxide derivative of prednisolone, enhances regulatory T cells in the lamina propria and protects against 2,4,6-trinitrobenzene sulfonic acid-induced colitis in mice
PNAS, November 26, 2002; 99(24): 15770 - 15775.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
P.-J. Chung, Y.-S. Chang, C.-L. Liang, and C.-L. Meng
Negative Regulation of Epstein-Barr Virus Latent Membrane Protein 1-mediated Functions by the Bone Morphogenetic Protein Receptor IA-binding Protein, BRAM1
J. Biol. Chem., October 11, 2002; 277(42): 39850 - 39857.
[Abstract] [Full Text] [PDF]

Home page
 EndocrinologyHome page
J. C. Webster, R. M. Huber, R. L. Hanson, P. M. Collier, T. F. Haws, J. K. Mills, T. C. Burn, and E. A. Allegretto
Dexamethasone and Tumor Necrosis Factor-{alpha} Act Together to Induce the Cellular Inhibitor of Apoptosis-2 Gene and Prevent Apoptosis in a Variety of Cell Types
Endocrinology, October 1, 2002; 143(10): 3866 - 3874.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Pharmacol.Home page
C. W. Lin, M. Nakane, M. Stashko, D. Falls, J. Kuk, L. Miller, R. Huang, C. Tyree, J. N. Miner, J. Rosen, et al.
trans-Activation and Repression Properties of the Novel Nonsteroid Glucocorticoid Receptor Ligand 2,5-Dihydro-9-hydroxy-10-methoxy-2,2,4-trimethyl-5-(1-methylcyclohexen-3-y1)-1H-[1]benzopyrano[3,4-f]quinoline (A276575) and Its Four Stereoisomers
Mol. Pharmacol., August 1, 2002; 62(2): 297 - 303.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Endocrinol.Home page
W. Eberhardt, M. Schulze, C. Engels, E. Klasmeier, and J. Pfeilschifter
Glucocorticoid-Mediated Suppression of Cytokine-Induced Matrix Metalloproteinase-9 Expression in Rat Mesangial Cells: Involvement of Nuclear Factor-{kappa}B and Ets Transcription Factors
Mol. Endocrinol., August 1, 2002; 16(8): 1752 - 1766.
[Abstract] [Full Text] [PDF]

Home page
 CarcinogenesisHome page
B. Glinghammar, H. Inoue, and J.J. Rafter
Deoxycholic acid causes DNA damage in colonic cells with subsequent induction of caspases, COX-2 promoter activity and the transcription factors NF-kB and AP-1
Carcinogenesis, May 1, 2002; 23(5): 839 - 845.
[Abstract] [Full Text] [PDF]

Home page
 EndocrinologyHome page
V. Chesnokova and S. Melmed
Minireview: Neuro-Immuno-Endocrine Modulation of the Hypothalamic-Pituitary-Adrenal (HPA) Axis by gp130 Signaling Molecules
Endocrinology, May 1, 2002; 143(5): 1571 - 1574.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Crit. Care Med.Home page
M. CONRON, E. ANDREAKOS, P. PANTELIDIS, C. SMITH, H. L. C. BEYNON, R. M. DUBOIS, and B. M. J. FOXWELL
Nuclear Factor-kappa B Activation in Alveolar Macrophages Requires Ikappa B kinase-beta , but Not Nuclear Factor-kappa B Inducing Kinase
Am. J. Respir. Crit. Care Med., April 1, 2002; 165(7): 996 - 1004.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
Y. Jiang, D. Chen, S.-C. Lyu, X. Ling, A. M. Krensky, and C. Clayberger
DQ 65-79, a Peptide Derived from HLA Class II, Induces I{kappa}B Expression
J. Immunol., April 1, 2002; 168(7): 3323 - 3328.
[Abstract] [Full Text] [PDF]

Home page
 FASEB J.Home page
J. J. RUDIGER, M. ROTH, M. P. BIHL, B. C. CORNELIUS, M. JOHNSON, R. ZIESCHE, and L.-H. BLOCK
Interaction of C/EBP{alpha} and the glucocorticoid receptor in vivo and in nontransformed human cells
FASEB J, February 1, 2002; 16(2): 177 - 184.
[Abstract] [Full Text] [PDF]

Home page
 EndocrinologyHome page
X. Xu, M. Otsuki, H. Saito, S. Sumitani, H. Yamamoto, N. Asanuma, H. Kouhara, and S. Kasayama
PPAR{alpha} and GR Differentially Down-Regulate the Expression of Nuclear Factor-{kappa}B-Responsive Genes in Vascular Endothelial Cells
Endocrinology, August 1, 2001; 142(8): 3332 - 3339.
[Abstract] [Full Text] [PDF]

Home page
 J. Am. Soc. Nephrol.Home page
D. SAHALI, A. PAWLAK, S. L. GOUVELLO, P. LANG, A. VALANCIUTE, P. REMY, C. LOIRAT, P. NIAUDET, A. BENSMAN, and G. GUELLAEN
Transcriptional and Post-Transcriptional Alterations of I {kappa}B{alpha} in Active Minimal-Change Nephrotic Syndrome
J. Am. Soc. Nephrol., August 1, 2001; 12(8): 1648 - 1658.
[Abstract] [Full Text] [PDF]

Home page
 BloodHome page
E. Ayroldi, G. Migliorati, S. Bruscoli, C. Marchetti, O. Zollo, L. Cannarile, F. D'Adamio, and C. Riccardi
Modulation of T-cell activation by the glucocorticoid-induced leucine zipper factor via inhibition of nuclear factor {kappa}B
Blood, August 1, 2001; 98(3): 743 - 753.
[Abstract] [Full Text] [PDF]

Home page
 Proc. Natl. Acad. Sci. USAHome page
J. C. Webster, R. H. Oakley, C. M. Jewell, and J. A. Cidlowski
Proinflammatory cytokines regulate human glucocorticoid receptor gene expression and lead to the accumulation of the dominant negative beta isoform: A mechanism for the generation of glucocorticoid resistance
PNAS, May 24, 2001; (2001) 121455098.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Endocrinol.Home page
S. Wissink, B. van der Burg, B. S. Katzenellenbogen, and P. T. van der Saag
Synergistic Activation of the Serotonin-1A Receptor by Nuclear Factor-{{kappa}}B and Estrogen
Mol. Endocrinol., April 1, 2001; 15(4): 543 - 552.
[Abstract] [Full Text]

Home page
 EndocrinologyHome page
M. E. Quaedackers, C. E. Van Den Brink, S. Wissink, R. H. M. M. Schreurs, J.-A. Gustafsson, P. T. Van Der Saag, and B. Van Der Burg
4-Hydroxytamoxifen Trans-Represses Nuclear Factor-{{kappa}}B Activity in Human Osteoblastic U2-OS Cells through Estrogen Receptor (ER){{alpha}}, and Not through ER{{beta}}
Endocrinology, March 1, 2001; 142(3): 1156 - 1166.
[Abstract] [Full Text] [PDF]

Home page
 Rheumatology (Oxford)Home page
C. W. Han, J. H. Choi, J. M. Kim, W. Y. Kim, K. Y. Lee, and G. T. Oh
Glucocorticoid-mediated repression of inflammatory cytokine production in fibroblast-like rheumatoid synoviocytes is independent of nuclear factor-{{kappa}}B activation induced by tumour necrosis factor {{alpha}}
Rheumatology, March 1, 2001; 40(3): 267 - 273.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
A. Agrawal, H. Cha-Molstad, D. Samols, and I. Kushner
Transactivation of C-Reactive Protein by IL-6 Requires Synergistic Interaction of CCAAT/Enhancer Binding Protein {{beta}} (C/EBP{{beta}}) and Rel p50
J. Immunol., February 15, 2001; 166(4): 2378 - 2384.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurosci.Home page
J. Xu, G.-M. Kim, S. H. Ahmed, J. Xu, P. Yan, X. M. Xu, and C. Y. Hsu
Glucocorticoid Receptor-Mediated Suppression of Activator Protein-1 Activation and Matrix Metalloproteinase Expression after Spinal Cord Injury
J. Neurosci., January 1, 2001; 21(1): 92 - 97.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
F. Bureau, S. Delhalle, G. Bonizzi, L. Fievez, S. Dogne, N. Kirschvink, A. Vanderplasschen, M.-P. Merville, V. Bours, and P. Lekeux
Mechanisms of Persistent NF-{kappa}B Activity in the Bronchi of an Animal Model of Asthma
J. Immunol., November 15, 2000; 165(10): 5822 - 5830.
[Abstract] [Full Text] [PDF]

Home page
 Genes Dev.Home page
R. M. Nissen and K. R. Yamamoto
The glucocorticoid receptor inhibits NFkappa B by interfering with serine-2 phosphorylation of the RNA polymerase II carboxy-terminal domain
Genes & Dev., September 15, 2000; 14(18): 2314 - 2329.
[Abstract] [Full Text]

Home page
 Mol. Endocrinol.Home page
L. I. McKay and J. A. Cidlowski
CBP (CREB Binding Protein) Integrates NF-{kappa}B (Nuclear Factor-{kappa}B) and Glucocorticoid Receptor Physical Interactions and Antagonism
Mol. Endocrinol., August 1, 2000; 14(8): 1222 - 1234.
[Abstract] [Full Text]

Home page
 Cancer Res.Home page
M. Holmes-McNary and A. S. Baldwin Jr.
Chemopreventive Properties of trans-Resveratrol Are Associated with Inhibition of Activation of the I{{kappa}}B Kinase
Cancer Res., July 1, 2000; 60(13): 3477 - 3483.
[Abstract] [Full Text]

Home page
 EndocrinologyHome page
J. Chung, E. S. Park, D. Kim, J. M. Suh, H. K. Chung, J. Kim, H. Kim, S. J. Park, O-Y. Kwon, H. K. Ro, et al.
Thyrotropin Modulates Interferon-{gamma}-Mediated Intercellular Adhesion Molecule-1 Gene Expression by Inhibiting Janus Kinase-1 and Signal Transducer and Activator of Transcription-1 Activation in Thyroid Cells
Endocrinology, June 1, 2000; 141(6): 2090 - 2097.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
R. Dimri, Y. Sharabi, and J. Shoham
Specific Inhibition of Glucocorticoid-Induced Thymocyte Apoptosis by Substance P
J. Immunol., March 1, 2000; 164(5): 2479 - 2486.
[Abstract] [Full Text] [PDF]

Home page
 Endocr. Rev.Home page
R. M. Sapolsky, L. M. Romero, and A. U. Munck
How Do Glucocorticoids Influence Stress Responses? Integrating Permissive, Suppressive, Stimulatory, and Preparative Actions
Endocr. Rev., February 1, 2000; 21(1): 55 - 89.
[Abstract] [Full Text]

Home page
 J. Biol. Chem.Home page
S. Wissink, O. Meijer, D. Pearce, B. van der Burg, and P. T. van der Saag
Regulation of the Rat Serotonin-1A Receptor Gene by Corticosteroids
J. Biol. Chem., January 14, 2000; 275(2): 1321 - 1326.
[Abstract] [Full Text] [PDF]

Home page
 Plant CellHome page
H.-H. Woo, M. J. Orbach, A. M. Hirsch, and M. C. Hawes
Meristem-Localized Inducible Expression of a UDP-Glycosyltransferase Gene Is Essential for Growth and Development in Pea and Alfalfa
PLANT CELL, December 1, 1999; 11(12): 2303 - 2316.
[Abstract]