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Molecular Endocrinology, Vol 9, 478-486, Copyright © 1995 by Endocrine Society

ARTICLES

The nuclear receptor steroidogenic factor 1 is essential for the formation of the ventromedial hypothalamic nucleus

Y Ikeda, X Luo, R Abbud, JH Nilson and KL Parker
Department of Medicine, Duke University Medical Center, Durham, North Carolina 27710, USA.

The nuclear receptor steroidogenic factor 1 (SF-1) regulates the biosynthesis of the two essential mediators of male sexual differentiation, androgens and Mullerian-inhibiting substance, and is required for adrenal and gonadal development and gonadotropin expression. SF-1 is also expressed in the embryonic ventral diencephalon, subsequently localizing to the ventromedial hypothalamic nucleus, a region important for reproductive behavior. Mice lacking SF- 1 secondary to targeted disruption of the Ftz-F1 gene had normal numbers and location of GnRH neurons but exhibited grossly impaired ventromedial hypothalamic nucleus structure. Despite their apparently normal GnRH neurons, treatment of Ftz-F1-disrupted mice with GnRH restored pituitary gonadotropin expression. These studies define SF-1's essential role within a discrete hypothalamic nucleus previously linked to reproduction.


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