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Molecular Endocrinology, Vol 9, 478-486, Copyright © 1995 by Endocrine Society

ARTICLES

The nuclear receptor steroidogenic factor 1 is essential for the formation of the ventromedial hypothalamic nucleus

Y Ikeda, X Luo, R Abbud, JH Nilson and KL Parker
Department of Medicine, Duke University Medical Center, Durham, North Carolina 27710, USA.

The nuclear receptor steroidogenic factor 1 (SF-1) regulates the biosynthesis of the two essential mediators of male sexual differentiation, androgens and Mullerian-inhibiting substance, and is required for adrenal and gonadal development and gonadotropin expression. SF-1 is also expressed in the embryonic ventral diencephalon, subsequently localizing to the ventromedial hypothalamic nucleus, a region important for reproductive behavior. Mice lacking SF- 1 secondary to targeted disruption of the Ftz-F1 gene had normal numbers and location of GnRH neurons but exhibited grossly impaired ventromedial hypothalamic nucleus structure. Despite their apparently normal GnRH neurons, treatment of Ftz-F1-disrupted mice with GnRH restored pituitary gonadotropin expression. These studies define SF-1's essential role within a discrete hypothalamic nucleus previously linked to reproduction.


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[Abstract] [Full Text] [PDF]

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[Abstract] [Full Text] [PDF]

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[Abstract] [Full Text] [PDF]

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[Abstract] [Full Text] [PDF]

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[Abstract] [Full Text] [PDF]

Home page
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[Abstract] [Full Text] [PDF]

Home page
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[Abstract] [Full Text] [PDF]

Home page
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[Abstract] [Full Text] [PDF]

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Home page
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[Full Text] [PDF]

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[Abstract] [PDF]

Home page
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[Abstract] [Full Text] [PDF]

Home page
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[Abstract] [Full Text]

Home page
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[Abstract] [Full Text]

Home page
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[Abstract] [Full Text]

Home page
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Home page
 J. Biol. Chem.Home page
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[Abstract] [Full Text] [PDF]

Home page
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[Abstract] [Full Text] [PDF]

Home page
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Home page
 J. Clin. Endocrinol. Metab.Home page
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[Abstract] [Full Text]

Home page
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Home page
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[Abstract] [Full Text]

Home page
 EndocrinologyHome page
T. W. Sandhoff, D. B. Hales, K. H. Hales, and M. P. McLean
Transcriptional Regulation of the Rat Steroidogenic Acute Regulatory Protein Gene by Steroidogenic Factor 1
Endocrinology, December 1, 1998; 139(12): 4820 - 4831.
[Abstract] [Full Text] [PDF]

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 Mol. Endocrinol.Home page
R. N. Yu, M. Ito, and J. L. Jameson
The Murine Dax-1 Promoter Is Stimulated by SF-1 (Steroidogenic Factor-1) and Inhibited by COUP-TF (Chicken Ovalbumin Upstream Promoter-Transcription Factor) via a Composite Nuclear Receptor-Regulatory Element
Mol. Endocrinol., July 1, 1998; 12(7): 1010 - 1022.
[Abstract] [Full Text]

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 J. Biol. Chem.Home page
L. M. Halvorson, M. Ito, J. L. Jameson, and W. W. Chin
Steroidogenic Factor-1 and Early Growth Response Protein 1 Act through Two Composite DNA Binding Sites to Regulate Luteinizing Hormone beta -Subunit Gene Expression
J. Biol. Chem., June 12, 1998; 273(24): 14712 - 14720.
[Abstract] [Full Text] [PDF]

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 Mol. Cell. Biol.Home page
P. A. Crawford, C. Dorn, Y. Sadovsky, and J. Milbrandt
Nuclear Receptor DAX-1 Recruits Nuclear Receptor Corepressor N-CoR to Steroidogenic Factor 1
Mol. Cell. Biol., May 1, 1998; 18(5): 2949 - 2956.
[Abstract] [Full Text]

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 Mol. Endocrinol.Home page
M. L. Brinkmeier, D. F. Gordon, J. M. Dowding, T. L. Saunders, S. K. Kendall, V. D. Sarapura, W. M. Wood, E. C. Ridgway, and S. A. Camper
Cell-Specific Expression of the Mouse Glycoprotein Hormone {alpha}-Subunit Gene Requires Multiple Interacting DNA Elements in Transgenic Mice and Cultured Cells
Mol. Endocrinol., May 1, 1998; 12(5): 622 - 633.
[Abstract] [Full Text]

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 Mol. Endocrinol.Home page
A. N. Harris and P. L. Mellon
The Basic Helix-Loop-Helix, Leucine Zipper Transcription Factor, USF (Upstream Stimulatory Factor), Is a Key Regulator of SF-1 (Steroidogenic Factor-1) Gene Expression in Pituitary Gonadotrope and Steroidogenic Cells
Mol. Endocrinol., May 1, 1998; 12(5): 714 - 726.
[Abstract] [Full Text]

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 Mol. Endocrinol.Home page
J. J. Tremblay, C. Lanctôt, and J. Drouin
The pan-Pituitary Activator of Transcription, Ptx1 (Pituitary Homeobox 1), Acts in Synergy with SF-1 and Pit1 and Is an Upstream Regulator of the Lim-Homeodomain Gene Lim3/Lhx3
Mol. Endocrinol., March 1, 1998; 12(3): 428 - 441.
[Abstract] [Full Text]

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 Mol. Endocrinol.Home page
J. Weck, P. C. Fallest, L. K. Pitt, and M. A. Shupnik
Differential Gonadotropin-Releasing Hormone Stimulation of Rat Luteinizing Hormone Subunit Gene Transcription by Calcium Influx and Mitogen-Activated Protein Kinase-Signaling Pathways
Mol. Endocrinol., March 1, 1998; 12(3): 451 - 457.
[Abstract] [Full Text]

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 J. Biol. Chem.Home page
D. Monte, F. DeWitte, and D. W. Hum
Regulation of the Human P450scc Gene by Steroidogenic Factor 1 Is Mediated by CBP/p300
J. Biol. Chem., February 20, 1998; 273(8): 4585 - 4591.
[Abstract] [Full Text] [PDF]

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 Mol. Endocrinol.Home page
M. Ito, R. N. Yu, and J. L. Jameson
Steroidogenic Factor-1 Contains a Carboxy-Terminal Transcriptional Activation Domain That Interacts with Steroid Receptor Coactivator-1
Mol. Endocrinol., February 1, 1998; 12(2): 290 - 301.
[Abstract] [Full Text]

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 Reproductive SciencesHome page
Y. Sadovsky and P. A. Crawford
Developmental and Physiologic Roles of the Nuclear Receptor Steroidogenic Factor-I in the Reproductive System
Reproductive Sciences, January 1, 1998; 5(1): 6 - 12.
[Abstract] [PDF]

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 J. Biol. Chem.Home page
H.-S. Choi, M. Chung, I. Tzameli, D. Simha, Y.-K. Lee, W. Seol, and D. D. Moore
Differential Transactivation by Two Isoforms of the Orphan Nuclear Hormone Receptor CAR
J. Biol. Chem., September 19, 1997; 272(38): 23565 - 23571.
[Abstract] [Full Text] [PDF]

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 Endocr. Rev.Home page
K. L. Parker and B. P. Schimmer
Steroidogenic Factor 1: A Key Determinant of Endocrine Development and Function
Endocr. Rev., June 1, 1997; 18(3): 361 - 377.
[Abstract] [Full Text]

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 Mol. Endocrinol.Home page
D. Liu, Y. Le Drean, M. Ekker, F. Xiong, and C. L. Hew
Teleost FTZ-F1 Homolog and Its Splicing Variant Determine the Expression of the Salmon Gonadotropin II{beta} Subunit Gene
Mol. Endocrinol., June 1, 1997; 11(7): 877 - 890.
[Abstract] [Full Text]

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 J. Clin. Endocrinol. Metab.Home page
M. S. Ramayya, J. Zhou, T. Kino, J. H. Segars, C. A. Bondy, and G. P. Chrousos
Steroidogenic Factor 1 Messenger Ribonucleic Acid Expression in Steroidogenic and Nonsteroidogenic Human Tissues: Northern Blot and in Situ Hybridization Studies
J. Clin. Endocrinol. Metab., June 1, 1997; 82(6): 1799 - 1806.
[Abstract] [Full Text] [PDF]

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 Endocr. Rev.Home page
U. B. Kaiser, P. M. Conn, and W. W. Chin
Studies of Gonadotropin-Releasing Hormone (GnRH) Action Using GnRH Receptor-Expressing Pituitary Cell Lines
Endocr. Rev., February 1, 1997; 18(1): 46 - 70.
[Abstract] [Full Text]

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 Mol. Endocrinol.Home page
K. G. Woodson, P. A. Crawford, Y. Sadovsky, and J. Milbrandt
Characterization of the Promoter of SF-1, an Orphan Nuclear Receptor Required for Adrenal and Gonadal Development
Mol. Endocrinol., February 1, 1997; 11(2): 117 - 126.
[Abstract] [Full Text]

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 Mol. Endocrinol.Home page
K. M. Caron, Y. Ikeda, S.-C. Soo, D. M. Stocco, K. L. Parker, and B. J. Clark
Characterization of the Promoter Region of the Mouse Gene Encoding the Steroidogenic Acute Regulatory Protein
Mol. Endocrinol., February 1, 1997; 11(2): 138 - 147.
[Abstract] [Full Text]

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 DevelopmentHome page
G Giuili, W. Shen, and H. Ingraham
The nuclear receptor SF-1 mediates sexually dimorphic expression of Mullerian Inhibiting Substance, in vivo
Development, January 5, 1997; 124(9): 1799 - 1807.
[Abstract] [PDF]

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 J. Biol. Chem.Home page
R. A. Keri and J. H. Nilson
A Steroidogenic Factor-1 Binding Site Is Required for Activity of the Luteinizing Hormone beta Subunit Promoter in Gonadotropes of Transgenic Mice
J. Biol. Chem., May 3, 1996; 271(18): 10782 - 10785.
[Abstract] [Full Text] [PDF]

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 J. Biol. Chem.Home page
M. Nomura, H. Nawata, and K.-i. Morohashi
Autoregulatory Loop in the Regulation of the Mammalian ftz-f1 Gene
J. Biol. Chem., April 5, 1996; 271(14): 8243 - 8249.
[Abstract] [Full Text] [PDF]

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 J. Biol. Chem.Home page
L. M. Halvorson, U. B. Kaiser, and W. W. Chin
Stimulation of Luteinizing Hormone beta Gene Promoter Activity by the Orphan Nuclear Receptor, Steroidogenic Factor-1
J. Biol. Chem., March 22, 1996; 271(12): 6645 - 6650.
[Abstract] [Full Text] [PDF]

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 DevelopmentHome page
E. Alarid, J. Windle, D. Whyte, and P. Mellon
Immortalization of pituitary cells at discrete stages of development by directed oncogenesis in transgenic mice
Development, January 10, 1996; 122(10): 3319 - 3329.
[Abstract] [PDF]

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 J. Biol. Chem.Home page
A. L. Jacob, J. Lund, P. Martinez, and L. Hedin
Acetylation of Steroidogenic Factor 1 Protein Regulates Its Transcriptional Activity and Recruits the Coactivator GCN5
J. Biol. Chem., September 28, 2001; 276(40): 37659 - 37664.
[Abstract] [Full Text] [PDF]


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