help button home button Endocrine Society Molecular Endocrinology ENDO 08 Sessions Library
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH
This version published online on May 28, 2009
Molecular Endocrinology, doi:10.1210/me.2009-0069
This Article
Right arrow Author Manuscript (PDF)
Right arrow All Versions of this Article:
23/10/1525    most recent
Author Manuscript (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow NURSA Molecule Pages Link
Right arrow Request Copyright Permission
Citing Articles
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Hofbauer, L. C
Right arrow Articles by Rauner, M.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Hofbauer, L. C
Right arrow Articles by Rauner, M.

Submitted on February 13, 2009
Accepted on May 20, 2009

MINIREVIEW: Live and let die: molecular effects of glucocorticoids on bone cells

Lorenz C Hofbauer* and Martina Rauner

Division of Endocrinology, Diabetes, and Bone Diseases, Department of Medicine III, Technical University, Dresden and Center of Regenerative Therapies Dresden (CRTD), Dresden, Germany

* To whom correspondence should be addressed. E-mail: lorenz.hofbauer{at}uniklinikum-dresden.de.

Glucocorticoids are efficient drugs that are used to treat various immune-mediated diseases, but their long-term administration is associated with multiple metabolic side effects, including osteoporosis. Molecular analyses of the mechanisms exerted by the glucocorticoid receptor have resulted in the development of glucocorticoid receptor agonists that selectively repress or activate glucocorticoid target genes. This review summarizes the cellular and molecular effects of glucocorticoids on bone cells and highlights the critical signaling pathways that may evolve into future therapeutic strategies.

NURSA Molecule Pages Link:

Nuclear Receptors:   GR
Ligands:   Dexamethasone  |  Hydrocortisone





HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH
Endocrinology Endocrine Reviews J. Clin. End. & Metab.
Molecular Endocrinology Recent Prog. Horm. Res. All Endocrine Journals
Copyright © 2009 by The Endocrine Society