help button home button Endocrine Society Molecular Endocrinology ENDO 08 Sessions Library
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH
This version published online on October 16, 2009
Molecular Endocrinology, doi:10.1210/me.2009-0149
This Article
Right arrow Author Manuscript (PDF)
Right arrow All Versions of this Article:
23/12/1940    most recent
Author Manuscript (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow NURSA Molecule Pages Link
Right arrow Request Copyright Permission
Google Scholar
Right arrow Articles by Firestone, G. L.
Right arrow Articles by Sundar, S. N.
PubMed
Right arrow PubMed Citation
Right arrow Articles by Firestone, G. L.
Right arrow Articles by Sundar, S. N.

Submitted on April 9, 2009
Accepted on July 17, 2009

Minireview: Modulation of Hormone Receptor Signaling by Dietary Anticancer Indoles

Gary L. Firestone* and Shyam N. Sundar

Department of Molecular and Cell Biology and The Cancer Research Laboratory, The University of California at Berkeley, Berkeley, California 94720-3200

* To whom correspondence should be addressed. E-mail: glfire{at}berkeley.edu.

Indole-3-carbinol and its diindole condensation product 3-3'-diindolylmethane are dietary phytochemicals that have striking anticarcinogenic properties in human cancer cells. Molecular, cellular, physiological, and clinical studies have documented that both indole-3-carbinol and 3-3'-diindolylmethane have potent endocrine modulating activities through a myriad of mechanisms. The focus of this review is to discuss the evidence that directly links the anticancer actions of these two indole compounds to the control of steroid receptor and growth factor receptor signaling.

NURSA Molecule Pages Link:

Nuclear Receptors:   ER-α  |  ER-β  |  AR
Ligands:   Estriol  |  Estrone  |  17β-estradiol





HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH
Endocrinology Endocrine Reviews J. Clin. End. & Metab.
Molecular Endocrinology Recent Prog. Horm. Res. All Endocrine Journals
Copyright © 2009 by The Endocrine Society