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Figure 3. Kidney D1 Activity and mRNA Expression in
TR-Deficient Mice under ND, Hypo- (LID), or Hyperthyroid (LID + 0.5 or
5.0 µg/ml T3, Respectively) Conditions
A and B, D1 induction was abolished in TRß-/-mice. C and D, Normal dose-dependent increase in D1 expression is
present in TR 1-/- mice (**, P <
0.01). E and F, Neither D1 activity nor mRNA expression was induced in
TR 1-/-TRß-/- mice. Activity
was determined for groups of four to eight mice and mRNA levels with
pools of three to five mice. The y axis is broken to accommodate the
low levels of activity measured in most samples.
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