help button home button Endocrine Society Molecular Endocrinology ENDO 08 Sessions Library
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Molecular Endocrinology, doi:10.1210/me.2004-0193
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Purchase Article
Right arrow View Shopping Cart
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow Request Copyright Permission
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Collins, S.
Right arrow Articles by Robidoux, J.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Collins, S.
Right arrow Articles by Robidoux, J.
Molecular Endocrinology 18 (9): 2123-2131
Copyright © 2004 by The Endocrine Society

Minireview

Learning New Tricks from Old Dogs: ß-Adrenergic Receptors Teach New Lessons on Firing Up Adipose Tissue Metabolism

Sheila Collins, Wenhong Cao and Jacques Robidoux

CIIT Centers for Health Research, Research Triangle Park, North Carolina 27709

Address all correspondence and requests for reprints to: Sheila Collins, Ph.D., CIIT Centers for Health Research, Six Davis Drive, Research Triangle Park, North Carolina 27709. E-mail: scollins{at}ciit.org.

The three ßAR (ß-adrenergic receptor) subtypes (ß1AR, ß2AR, and ß3AR) are members of the large family of G protein-coupled receptors, each of which is coupled to G{alpha}s and increases in intracellular cAMP levels. In white adipose tissues, catecholamine activation of the ßARs leads to the mobilization of stored fatty acids and regulates release of several adipokines, whereas in brown adipose tissue they stimulate the specialized process of adaptive nonshivering thermogenesis. Noteworthy, in most models of obesity the ßAR system is dysfunctional, and its ability to stimulate lipolysis and thermogenesis are both impaired. Nevertheless, selective agonists for the ß3AR, a subtype that is found predominantly in adipocytes, have been able to prevent or reverse obesity and accompanying insulin resistance in animal models. Whether this is a viable therapeutic option for human obesity is much debated with regard to the existence of brown adipocytes in humans or their ability to be recruited. Nevertheless, probing the physiological changes in adrenoceptor function in rodent obesity, as well as the process by which ß3AR agonists promote a thermogenic shift in fuel use, have yielded unexpected new insights into ßAR signaling and adipocyte physiology. These include the recent discovery of an essential role of p38 MAPK in mediating adaptive thermogenesis, as well as the accessory role of the ERK MAPK pathway for the control of lipolysis. Because these metabolic events were traditionally ascribed solely to the cAMP/protein kinase A system, the integration of these signaling mechanisms may pose new therapeutic directions in the quest to counter the obesity epidemic in our midst.




This article has been cited by other articles:


Home page
 J. Lipid Res.Home page
R. Zechner, P. C. Kienesberger, G. Haemmerle, R. Zimmermann, and A. Lass
Adipose triglyceride lipase and the lipolytic catabolism of cellular fat stores
J. Lipid Res., January 1, 2009; 50(1): 3 - 21.
[Abstract] [Full Text] [PDF]

Home page
 Endocr. Rev.Home page
M. Prentki and S. R. M. Madiraju
Glycerolipid Metabolism and Signaling in Health and Disease
Endocr. Rev., October 1, 2008; 29(6): 647 - 676.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
P. Lau, R. L. Fitzsimmons, S. Raichur, S.-C. M. Wang, A. Lechtken, and G. E. O. Muscat
The Orphan Nuclear Receptor, ROR{alpha}, Regulates Gene Expression That Controls Lipid Metabolism: STAGGERER (SG/SG) MICE ARE RESISTANT TO DIET-INDUCED OBESITY
J. Biol. Chem., June 27, 2008; 283(26): 18411 - 18421.
[Abstract] [Full Text] [PDF]

Home page
 EndocrinologyHome page
M. A. Pearen, S. A. Myers, S. Raichur, J. G. Ryall, G. S. Lynch, and G. E. O. Muscat
The Orphan Nuclear Receptor, NOR-1, a Target of {beta}-Adrenergic Signaling, Regulates Gene Expression that Controls Oxidative Metabolism in Skeletal Muscle
Endocrinology, June 1, 2008; 149(6): 2853 - 2865.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Endocrinol.Home page
N. Kumar, D. Liu, H. Wang, J. Robidoux, and S. Collins
Orphan Nuclear Receptor NOR-1 Enhances 3',5'-Cyclic Adenosine 5'-Monophosphate-Dependent Uncoupling Protein-1 Gene Transcription
Mol. Endocrinol., May 1, 2008; 22(5): 1057 - 1064.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Cell. Biol.Home page
H. Wang, Y. Zhang, E. Yehuda-Shnaidman, A. V. Medvedev, N. Kumar, K. W. Daniel, J. Robidoux, M. P. Czech, D. J. Mangelsdorf, and S. Collins
Liver X Receptor {alpha} Is a Transcriptional Repressor of the Uncoupling Protein 1 Gene and the Brown Fat Phenotype
Mol. Cell. Biol., April 1, 2008; 28(7): 2187 - 2200.
[Abstract] [Full Text] [PDF]

Home page
 J. Lipid Res.Home page
D. L. Brasaemle
Thematic review series: Adipocyte Biology. The perilipin family of structural lipid droplet proteins: stabilization of lipid droplets and control of lipolysis
J. Lipid Res., December 1, 2007; 48(12): 2547 - 2559.
[Abstract] [Full Text] [PDF]

Home page
 J. Lipid Res.Home page
T. J. Bartness and C. K. Song
Thematic review series: Adipocyte Biology. Sympathetic and sensory innervation of white adipose tissue
J. Lipid Res., August 1, 2007; 48(8): 1655 - 1672.
[Abstract] [Full Text] [PDF]

Home page
 Diabetes CareHome page
I. Bogacka, T. W. Gettys, L. de Jonge, T. Nguyen, J. M. Smith, H. Xie, F. Greenway, and S. R. Smith
The Effect of {beta}-Adrenergic and Peroxisome Proliferator-Activated Receptor-{gamma} Stimulation on Target Genes Related to Lipid Metabolism in Human Subcutaneous Adipose Tissue
Diabetes Care, May 1, 2007; 30(5): 1179 - 1186.
[Abstract] [Full Text] [PDF]

Home page
 DiabetesHome page
Q. Wu, M. Kazantzis, H. Doege, A. M. Ortegon, B. Tsang, A. Falcon, and A. Stahl
Fatty Acid Transport Protein 1 Is Required for Nonshivering Thermogenesis in Brown Adipose Tissue
Diabetes, December 1, 2006; 55(12): 3229 - 3237.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Endocrinol. Metab.Home page
H. Kim, P. A. Pennisi, O. Gavrilova, S. Pack, W. Jou, J. Setser-Portas, J. East-Palmer, Y. Tang, V. C. Manganiello, and D. LeRoith
Effect of adipocyte beta3-adrenergic receptor activation on the type 2 diabetic MKR mice
Am J Physiol Endocrinol Metab, June 1, 2006; 290(6): E1227 - E1236.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Cell. Biol.Home page
J. Robidoux, W. Cao, H. Quan, K. W. Daniel, F. Moukdar, X. Bai, L. M. Floering, and S. Collins
Selective Activation of Mitogen-Activated Protein (MAP) Kinase Kinase 3 and p38{alpha} MAP Kinase Is Essential for Cyclic AMP-Dependent UCP1 Expression in Adipocytes
Mol. Cell. Biol., July 1, 2005; 25(13): 5466 - 5479.
[Abstract] [Full Text] [PDF]

Home page
 J. Clin. Endocrinol. Metab.Home page
D. C. Adler-Wailes, H. Liu, F. Ahmad, N. Feng, C. Londos, V. Manganiello, and J. A. Yanovski
Effects of the Human Immunodeficiency Virus-Protease Inhibitor, Ritonavir, on Basal and Catecholamine-Stimulated Lipolysis
J. Clin. Endocrinol. Metab., June 1, 2005; 90(6): 3251 - 3261.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
M. A. Maxwell, M. E. Cleasby, A. Harding, A. Stark, G. J. Cooney, and G. E. O. Muscat
Nur77 Regulates Lipolysis in Skeletal Muscle Cells: EVIDENCE FOR CROSS-TALK BETWEEN THE {beta}-ADRENERGIC AND AN ORPHAN NUCLEAR HORMONE RECEPTOR PATHWAY
J. Biol. Chem., April 1, 2005; 280(13): 12573 - 12584.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Endocrinology Endocrine Reviews J. Clin. End. & Metab.
Molecular Endocrinology Recent Prog. Horm. Res. All Endocrine Journals
Copyright © 2004 by The Endocrine Society