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This version published online on June 7, 2002
Molecular Endocrinology, doi:10.1210/me.2002-0106
A more recent version of this article appeared on August 1, 2002
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Submitted on March 14, 2002
Accepted on April 25, 2002

The Glucocorticoid Receptor: Coding a Diversity of Proteins and Responses through a Single Gene

Matthew R. Yudt1 and John A. Cidlowski1*

1 Laboratory of Signal Transduction, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, North Carolina 27709

* To whom correspondence should be addressed.

The ability of natural and synthetic glucocorticoids to elicit numerous and diverse physiological responses is remarkable. How the product of a single gene can participate in such a myriad of cell- and tissue-specific pathways has remained largely unknown. The last several years have seen increased description of glucocorticoid receptor (GR) protein isoforms. Here we review the current state of knowledge regarding naturally occurring GR isoforms and discuss how this array of receptor species generates the diversity associated with the glucocorticoid response. We propose that the multiplicity of receptor forms have unique tissue-specific actions on the downstream biology providing a mechanism to create GR signaling networks.

NURSA Molecule Pages Link:

Nuclear Receptors:   GR
Ligands:   Dexamethasone  |  Hydrocortisone  |  RU486



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