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This version published online on August 7, 2003
Molecular Endocrinology, doi:10.1210/me.2003-0023
A more recent version of this article appeared on November 1, 2003
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Submitted on January 22, 2003
Accepted on July 30, 2003

Compromised Reproductive Function in Adult Female Mice Selectively Expressing Mutant ErbB-1 Tyrosine Kinase Receptors in Astroglia

Biao Li1, Zhihui Yang1, Jingwen Hou1, April McCracken1, M. Anita Jennings1, and Mark YJ. Ma1*

1 Center for Human Molecular Genetics, Munroe-Meyer Institute, Department of Genetics, Cell Biology & Anatomy, University of Nebraska Medical Center, Omaha, NE 68198.

* To whom correspondence should be addressed. E-mail: yma{at}unmc.edu.

The ErbB-1 tyrosine kinase receptor plays critical roles in regulating physiological functions. This receptor-mediated signaling in astroglia has been implicated in controlling female sexual development via activating neurons that release LH-releasing hormone (LHRH), the neuropeptide required for the secretion of LH. It remains unknown whether astroglial ErbB-1 receptors are necessary for maintaining normal adult reproductive function. Here we provide genetic evidence that astroglia-specific and time-controlled disruption of ErbB-1 receptor signaling by expressing mutant ErbB-1 receptors leads to compromised reproduction due to alteration in LHRH neuron-controlled secretion of LH in adult female mice. Therefore, astroglial ErbB-1 receptors are required for controlling LHRH neuronal function and thus maintaining adult reproduction, suggesting that compromised astroglial ErbB-1 signaling may also contribute to reproductive abnormalities in aging females.
Key words: Tyrosine kinase receptor • Ecdysone receptor • LHRH neuron • Hypothalamus • Estrous cycle • Reproduction • Aging




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