| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH |
| |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Submitted on April 9, 2003
Accepted on January 8, 2004
Laboratoire de Génétique moléculaire, Institut de recherches cliniques de Montréal (IRCM), Montréal QC Canada H2W 1R7; Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, TX 77030-3498 USA; Division of Molecular Neurobiology, National Institute for Medical Research, London NW7 1AA UK
* To whom correspondence should be addressed. E-mail: jacques.drouin{at}ircm.qc.ca.
NeuroD1(BETA2) and Tpit are cell-specific activators of pituitary proopiomelanocortin (POMC) gene transcription. Expression of both factors slightly precedes that of POMC at e12.5 of mouse pituitary development. We now report that NeuroD1(BETA2) is required for early corticotroph differentiation. In agreement with the transcriptional synergism observed between Tpit and bHLH dimers containing NeuroD1(BETA2), POMC expression is delayed in NeuroD1-deficient mice. However, this differentiation defect does not reflect a change of corticotroph commitment as revealed by Tpit expression. The delay of corticotroph terminal differentiation is transient and coincides with the developmental window of NeuroD1 expression in corticotrophs. In contrast to their requirement in other NeuroD1-expressing cells, the neurogenin genes do not appear to be necessary for corticotroph differentiation. Taken together with a similar requirement of Tpit for corticotroph differentiation but not for commitment, the present data indicate that the POMC promoter is a point of convergence for independent corticotrophs differentiating signals.
This article has been cited by other articles:
 |
|
 |
|
  S. M. Dupre, D. W. Burt, R. Talbot, A. Downing, D. Mouzaki, D. Waddington, B. Malpaux, J. R. E. Davis, G. A. Lincoln, and A. S. I. Loudon Identification of Melatonin-Regulated Genes in the Ovine Pituitary Pars Tuberalis, a Target Site for Seasonal Hormone Control Endocrinology, November 1, 2008; 149(11): 5527 - 5539. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 P.-L. Lavoie, L. Budry, A. Balsalobre, and J. Drouin Developmental Dependence on NurRE and EboxNeuro for Expression of Pituitary Proopiomelanocortin Mol. Endocrinol., July 1, 2008; 22(7): 1647 - 1657. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. Vallette-Kasic, C. Couture, A. Balsalobre, Y. Gauthier, L. Metherell, M. Dattani, and J. Drouin The TPIT Gene Mutation M86R Associated with Isolated Adrenocorticotropin Deficiency Interferes with Protein: Protein Interactions J. Clin. Endocrinol. Metab., October 1, 2007; 92(10): 3991 - 3999. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A Fratticci, F A Grieco, C Spilioti, F Giangaspero, L Ventura, V Esposito, M Piccirilli, A Santoro, A Gulino, G Cantore, et al. Differential expression of neurogenins and NeuroD1 in human pituitary tumours J. Endocrinol., September 1, 2007; 194(3): 475 - 484. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 X. Zhu, A. S. Gleiberman, and M. G. Rosenfeld Molecular Physiology of Pituitary Development: Signaling and Transcriptional Networks Physiol Rev, July 1, 2007; 87(3): 933 - 963. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Kita, I. Imayoshi, M. Hojo, M. Kitagawa, H. Kokubu, R. Ohsawa, T. Ohtsuka, R. Kageyama, and N. Hashimoto Hes1 and Hes5 Control the Progenitor Pool, Intermediate Lobe Specification, and Posterior Lobe Formation in the Pituitary Development Mol. Endocrinol., June 1, 2007; 21(6): 1458 - 1466. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 X. Zhu, J. Zhang, J. Tollkuhn, R. Ohsawa, E. H. Bresnick, F. Guillemot, R. Kageyama, and M. G. Rosenfeld Sustained Notch signaling in progenitors is required for sequential emergence of distinct cell lineages during organogenesis Genes & Dev., October 1, 2006; 20(19): 2739 - 2753. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 H.-M. Pogoda, S. von der Hardt, W. Herzog, C. Kramer, H. Schwarz, and M. Hammerschmidt The proneural gene ascl1a is required for endocrine differentiation and cell survival in the zebrafish adenohypophysis Development, March 15, 2006; 133(6): 1079 - 1089. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Nudi, J.-F. Ouimette, and J. Drouin Bone Morphogenic Protein (Smad)-Mediated Repression of Proopiomelanocortin Transcription by Interference with Pitx/Tpit Activity Mol. Endocrinol., May 1, 2005; 19(5): 1329 - 1342. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 E. Batsche, P. Moschopoulos, J. Desroches, S. Bilodeau, and J. Drouin Retinoblastoma and the Related Pocket Protein p107 Act as Coactivators of NeuroD1 to Enhance Gene Transcription J. Biol. Chem., April 22, 2005; 280(16): 16088 - 16095. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 K. Chu and M.-J. Tsai Neuronatin, a Downstream Target of BETA2/NeuroD1 in the Pancreas, Is Involved in Glucose-Mediated Insulin Secretion Diabetes, April 1, 2005; 54(4): 1064 - 1073. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 I. O. Nasonkin, R. D. Ward, L. T. Raetzman, A. F. Seasholtz, T. L. Saunders, P. J. Gillespie, and S. A. Camper Pituitary hypoplasia and respiratory distress syndrome in Prop1 knockout mice Hum. Mol. Genet., November 15, 2004; 13(22): 2727 - 2735. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH |
| Endocrinology | Endocrine Reviews | J. Clin. End. & Metab. |
| Molecular Endocrinology | Recent Prog. Horm. Res. | All Endocrine Journals |
