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Submitted on February 20, 2004
Accepted on August 5, 2004
Global Business Intelligence Center, NV Organon, Oss, The Netherlands; Center of Reproductive Medicine, Erasmus Medical Center, Rotterdam, The Netherlands; Department of Obstetrics and Gynecology, Flevohospital, Almere, The Netherlands; Department of Molecular Design and Informatics, NV Organon, Oss, The Netherlands; Department of Pharmacology, NV Organon, Oss, The Netherlands; Department of Reproductive Medicine, University Medical Center Utrecht, Utrecht, The Netherlands
* To whom correspondence should be addressed. E-mail: erik.jansen{at}organon.com.
Polycystic ovary syndrome (PCOS) represents the most common cause of anovulatory infertility and affects 5-10% of women of reproductive age. The etiology of PCOS is still unknown. The current study is the first to describe consistent differences in gene expression profiles in human ovaries comparing PCOS patients vs. healthy normo-ovulatory individuals. The microarray analysis of PCOS vs. normal ovaries identifies dysregulated expression of genes encoding components of several biological pathways or systems such as Wnt-signaling, extracellular matrix components and immunological factors. Resulting data may provide novel clues for ovarian dysfunction in PCOS. Intriguingly, the gene expression profiles of ovaries from (long-term) androgen treated female-to-male transsexuals (TSX) show considerable overlap with PCOS. This observation provides supportive evidence that androgens play a key role in the pathogenesis of PCOS. Presented data may contribute to a better understanding of dysregulated pathways in PCOS, which might ultimately reveal novel leads for therapeutic intervention.
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