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This version published online on March 23, 2006
Molecular Endocrinology, doi:10.1210/me.2005-0459
A more recent version of this article appeared on January 1, 2007
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Submitted on November 17, 2005
Accepted on March 16, 2006

Estrogen receptor-{beta}: Recent lessons from in vivo studies

Heather A. Harris*

Women's Health and Musculoskeletal Biology, Wyeth Research, Collegeville PA 19426

* To whom correspondence should be addressed. E-mail: harrish{at}wyeth.com.

The unexpected discovery of a second form of the estrogen receptor (ER) designated ER{beta}, surprised and energized the field of estrogen research. In the nine years since its identification, the remarkable efforts from academic and industrial scientists of many disciplines have made significant progress in elucidating its biology. A powerful battery of tools including knockout mice as well as a panel of receptor selective agonists have allowed an investigation into the role of ER{beta}. To date, in vivo efficacy studies are limited to rodents. Current data indicate that ER{beta} plays a minor role in mediating estrogen action in the uterus, on the hypothalamus/pituitary, the skeleton and other classic estrogen target tissues. However, a clear role for ER{beta} has been established in the ovary, cardiovascular system, and brain as well as in several animal models of inflammation including arthritis, endometriosis, inflammatory bowel disease and sepsis. The next phase of research will focus on elucidating, at a molecular level, how ER{beta} exerts these diverse effects and exploring the clinical utility of ER{beta} selective agonists.

NURSA Molecule Pages Link:

Nuclear Receptors:   ERα  |  ERβ
Ligands:   17β-Estradiol  |  Fulvestrant



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