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This version published online on May 29, 2007
Molecular Endocrinology, doi:10.1210/me.2006-0408
A more recent version of this article appeared on September 1, 2007
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Submitted on September 28, 2006
Accepted on May 22, 2007

Mechanisms regulating oocyte meiotic resumption: roles of mitogen-activated protein kinase

Cheng-Guang Liang, You-Qiang Su, Heng-Yu Fan, Heide Schatten, and Qing-Yuan Sun*

State Key Laboratory of Reproductive Biology, Institute of Zoology, and Graduate School, Chinese Academy of Sciences, Beijing 100080, P.R. China; The Jackson Laboratory, Bar Harbor, Maine 04609, USA; Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, Texas 77030, USA; Department of Veterinary Pathobiology, University of Missouri-Columbia, MO 65211, USA

* To whom correspondence should be addressed. E-mail: sunqy{at}ioz.ac.cn.

Oocyte meiotic maturation is one of the important physiological requirements for species survival. However, little is known about the detailed events occurring during this process. A number of studies have demonstrated that mitogen-activated protein kinase (MAPK) plays a pivotal role in the regulation of meiotic cell cycle progression in oocytes. But controversial findings have been reported in both lower vertebrates and mammals. In this review, we have summarized the roles of MAPK cascade and related signal pathways in oocyte meiotic reinitiation in both lower vertebates and mammals. We have also tried to reconcile the paradoxical results and highlight the new findings concerning the function of MAPK in both oocytes and the surrounding follicular somatic cells. The unresolved questions and future research directions regarding to the role of MAPK in meiotic resumption are addressed.




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