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This version published online on March 27, 2007
Molecular Endocrinology, doi:10.1210/me.2007-0065
Molecular Endocrinology Vol. 0, No. 2007 200700651-
doi:10.1210/me.2007-0065
Copyright © 2007 by the Endocrine Society.
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*Immune System and Disorders
*Steroids

Submitted on February 1, 2007
Accepted on March 12, 2007

The MIF-Glucocorticoid Dyad: Regulation of Inflammation and Immunity

Harry Flaster, Jürgen Bernhagen, Thierry Calandra, and Richard Bucala*

Institute of Biochemistry, University Hospital RWTH Aachen, Germany, Infectious Diseases Service, Department of Medicine, CHUV, Lausanne, Switzerland, Yale University School of Medicine, New Haven, CT, USA

* To whom correspondence should be addressed. E-mail: Richard.Bucala{at}Yale.edu.

The cytokine macrophage migration inhibitor factor (MIF) occupies a unique position in physiology by its ability directly regulate the immunosuppressive actions of glucocorticoids. We review herein the interactions between MIF and glucocorticoids within the immune system and discuss the relevance of the MIF-glucocorticoid regulatory dyad in physiology and immunopathology. Therapeutic antagonism of MIF may be an effective approach for steroid-sparing therapies in patients with refractory autoimmune or inflammatory diseases.

NURSA Molecule Pages Link:

Ligands:   Dexamethasone  |  Hydrocortisone



This article has been cited by other articles:


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Experimental Biology and Medicine, May 1, 2008; 233(5): 620 - 626.
[Abstract] [Full Text] [PDF]


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