help button home button Endocrine Society Molecular Endocrinology ENDO 08 Sessions Library
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH
This version published online on April 24, 2007
Molecular Endocrinology, doi:10.1210/me.2007-0079
Molecular Endocrinology Vol. 0, No. 2007 200700791-
doi:10.1210/me.2007-0079
Copyright © 2007 by the Endocrine Society.
This Article
Right arrow Author Manuscript (PDF)
Right arrow All Versions of this Article:
21/8/1745    most recent
Author Manuscript (PDF)
Right arrow Purchase Article
Right arrow View Shopping Cart
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow NURSA Molecule Pages Link
Right arrow Request Copyright Permission
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Yamamoto, H.
Right arrow Articles by Auwerx, J.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Yamamoto, H.
Right arrow Articles by Auwerx, J.
Right arrowPubmed/NCBI databases
Medline Plus Health Information
*Cancer
*Degenerative Nerve Diseases

Submitted on February 12, 2007
Accepted on April 18, 2007

SIRTUIN FUNCTIONS IN HEALTH AND DISEASE

Hiroyasu Yamamoto, Kristina Schoonjans, and Johan Auwerx*

Institut de Génétique et de Biologie Moléculaire et Cellulaire (IGBMC), CNRS / INSERM / ULP, 67404 Illkirch, France; Institut Clinique de la Souris, 67404 Illkirch, France

* To whom correspondence should be addressed. E-mail: auwerx{at}igbmc.u-strasbg.fr.

Sirtuins or Sir2-related enzymes have originally been defined as a family NAD+-dependent enzymes that deacetylate lysine residue on various proteins. Certain sirtuins have in addition an ADP-ribosyltransferase activity. The sirtuins are remarkably conserved throughout evolution from archaebacteria to eukaryotes. The mammalian sirtuins, SIRT1-7, are implicated in a variety of cellular functions ranging from gene silencing, over the control of the cell cycle and apoptosis, to energy homeostasis. On a whole body level, the wide range of cellular activities of the sirtuins suggest that they could constitute therapeutic targets to combat metabolic, neurodegenerative, and proliferative diseases. Here, we review some of the recent data related to the sirtuins and discuss their mode of action, their biological role in cellular and organismal models, and their possible association to age-related human diseases.
Key words: Sir2 • SIRT1-7 • Aging • Caloric restriction • Mitochondria • Metabolic diseases • Neurodegenerative diseases

NURSA Molecule Pages Link:

Nuclear Receptors:   PPARγ  |  HNF4α  |  AR
Coregulators:   PGC-1  |  Sirt1



This article has been cited by other articles:


Home page
 J. Biol. Chem.Home page
B. Buelow, Y. Song, and A. M. Scharenberg
The Poly(ADP-ribose) Polymerase PARP-1 Is Required for Oxidative Stress-induced TRPM2 Activation in Lymphocytes
J. Biol. Chem., September 5, 2008; 283(36): 24571 - 24583.
[Abstract] [Full Text] [PDF]

Home page
 Proc. Natl. Acad. Sci. USAHome page
P. T. Pfluger, D. Herranz, S. Velasco-Miguel, M. Serrano, and M. H. Tschop
Sirt1 protects against high-fat diet-induced metabolic damage
PNAS, July 15, 2008; 105(28): 9793 - 9798.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Endocrinol.Home page
C. Wang, M. J. Powell, V. M. Popov, and R. G. Pestell
Acetylation in Nuclear Receptor Signaling and the Role of Sirtuins
Mol. Endocrinol., March 1, 2008; 22(3): 539 - 545.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH
Endocrinology Endocrine Reviews J. Clin. End. & Metab.
Molecular Endocrinology Recent Prog. Horm. Res. All Endocrine Journals
Copyright © 2007 by The Endocrine Society