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This version published online on August 7, 2007
Molecular Endocrinology, doi:10.1210/me.2007-0213
A more recent version of this article appeared on November 1, 2007
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Submitted on April 25, 2007
Accepted on July 31, 2007

The Nuclear Receptor Cofactor RIP140 is Required for the Regulation of Hepatic Lipid and Glucose Metabolism by LXR

Birger Herzog, Magnus Hallberg, Asha Seth, Angela Woods, Roger White, and Malcolm G. Parker*

Institute of Reproductive and Developmental Biology, and MRC Cellular Stress Group, Clinical Sciences Centre, Imperial College London, Faculty of Medicine, Du Cane Road, London W12 0NN, United Kingdom

* To whom correspondence should be addressed. E-mail: m.parker{at}imperial.ac.uk.

The liver X receptors (LXRs) are nuclear receptors which play important roles in the regulation of lipid metabolism. In this study, we demonstrate that RIP140 is a cofactor for LXR in liver. Analysis of RIP140 null mice and hepatocytes depleted of RIP140 indicate that the cofactor is essential for the ability of LXR to activate the expression of a set of genes required for lipogenesis. Furthermore we demonstrate that RIP140 is required for the ability of LXR to repress the expression of the PEPCK gene in Fao cells and mice. Thus, we conclude that the function of RIP140 as a cofactor for LXR in liver varies according to the target genes and metabolic process, serving as a coactivator in lipogenesis but as a corepressor in gluconeogenesis.

NURSA Molecule Pages Link:

Nuclear Receptors:   LXRβ  |  LXRα
Coregulators:   RIP140
Ligands:   T0901317



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