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This version published online on July 31, 2007
Molecular Endocrinology, doi:10.1210/me.2007-0250
A more recent version of this article appeared on January 1, 2008
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Submitted on May 11, 2007
Accepted on July 18, 2007

SRY and the Standoff in Sex Determination

Leo DiNapoli and Blanche Cape1*

Department of Cell Biology, Duke University, Durham NC, 27710

* To whom correspondence should be addressed. E-mail: b.capel{at}cellbio.duke.edu.

SRY was identified as the mammalian sex-determining gene more than 15 years ago and has been extensively studied since. Although many of the pathways regulating sexual differentiation have been elucidated, direct downstream targets of SRY are still unclear, making a ‘top down’ approach difficult. However, recent work has demonstrated that the fate of the gonad is actively contested by both male-promoting and female-promoting signals. Sox9 and Fgf9 push gonads towards testis differentiation. These two genes are opposed by Wnt4, and possibly RSPO1, which push gonads towards ovary differentiation. In this review, we will discuss the history of the field, current findings, and exciting new directions in vertebrate sex-determination.

X, Y, and the Gonad
Key words: SRY • sex determination • XX • XY • sex reversal • Wnt • Fgf • gonad






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