SPECIAL FEATURES:

Donald B. DeFranco

Molecular Endocrinology: The Next Five Years
Mol Endocrinol 2009 23: 1, doi:10.1210/me.2008-0396 [Full Text] [PDF]  

Jiandie D. Lin

Minireview: The PGC-1 Coactivator Networks: Chromatin-Remodeling and Mitochondrial Energy Metabolism
Mol Endocrinol 2009 23: 2-10, doi:10.1210/me.2008-0344 [Abstract] [Full Text] [PDF]  
PGC-1 coactivators control mitochondrial metabolism through chromatin-remodeling.

ORIGINAL RESEARCH:

Mayoura Keophiphath, Vincent Achard, Corneliu Henegar, Christine Rouault, Karine Clément, and Danièle Lacasa

Macrophage-Secreted Factors Promote a Profibrotic Phenotype in Human Preadipocytes
Mol Endocrinol 2009 23: 11-24, doi:10.1210/me.2008-0183 [Abstract] [Full Text] [PDF]  
An inflammatory environment leads to profound modifications of the human preadipocyte phenotype with increased proliferation, migration and the production of fibrotic components.

Elena P. Sablin, Raymond D. Blind, Irina N. Krylova, Jared G. Ingraham, Fang Cai, Jon D. Williams, Robert J. Fletterick, and Holly A. Ingraham

Structure of SF-1 Bound by Different Phospholipids: Evidence for Regulatory Ligands
Mol Endocrinol 2009 23: 25-34, doi:10.1210/me.2007-0508 [Abstract] [Full Text] [PDF] [Supplemental Data]  
The crystal structure of SF-1 bound by an exchanged-exogenous phospholipid ligand reveals two variable surface loops important for both ligand uptake and transcriptional activity.

Taksum Cheng, Nathan J. Pavlos, Cathy Wang, Jamie We-Yin Tan, Jian Ming Lin, Jillian Cornish, Ming-Hao Zheng, and Jiake Xu

Mutations within the TNF-Like Core Domain of RANKL Impair Osteoclast Differentiation and Activation
Mol Endocrinol 2009 23: 35-46, doi:10.1210/me.2007-0465 [Abstract] [Full Text] [PDF] [Supplemental Data]  
Recombinant rRANKL mutants within the TNF-like core domain form short-lived hybrid trimeric complexes with wildtype RANKL, thus inhibiting RANKL-induced osteoclast differentiation and bone resorption.

Shunichi Matsumoto, Koshi Hashimoto, Masanobu Yamada, Teturou Satoh, Junko Hirato, and Masatomo Mori

Liver X Receptor- Regulates Proopiomelanocortin (POMC) Gene Transcription in the Pituitary
Mol Endocrinol 2009 23: 47-60, doi:10.1210/me.2007-0533 [Abstract] [Full Text] [PDF]  
LXR- is expressed in the ACTH-immunoreactive cells in the pituitary and positively regulates proopiomelanocortin (POMC) gene expression in the anterior pituitary lobe at the transcriptional level.

Angeliki Magklara and Catharine L. Smith

A Composite Intronic Element Directs Dynamic Binding of the Progesterone Receptor and GATA-2
Mol Endocrinol 2009 23: 61-73, doi:10.1210/me.2008-0028 [Abstract] [Full Text] [PDF] [Supplemental Data]  
Progesterone receptor cooperates with GATA-2 to activate the FKBP5 gene in a cyclic fashion through a composite element located in the first intron.

Thomas J. Berrodin, Ken C. N. Chang, Barry S. Komm, Leonard P. Freedman, and Sunil Nagpal

Differential Biochemical and Cellular Actions of Premarin Estrogens: Distinct Pharmacology of Bazedoxifene-Conjugated Estrogens Combination
Mol Endocrinol 2009 23: 74-85, doi:10.1210/me.2008-0366 [Abstract] [Full Text] [PDF] [Supplemental Data]  
The authors show that the major components of Conjugated Estrogens (CE) induce different ER LBD conformations, and demonstrate distinct pharmacology of bazedoxifene/CE combination when compared to that obtained by the pairing of CE with other SERMs.

Il Je Cho and Sang Geon Kim

A Novel Mitogen-Activated Protein Kinase Phosphatase-1 and Glucocorticoid Receptor (GR) Interacting Protein-1-Dependent Combinatorial Mechanism of Gene Transrepression by GR
Mol Endocrinol 2009 23: 86-99, doi:10.1210/me.2008-0257 [Abstract] [Full Text] [PDF] [Supplemental Data]  
Glucocorticoid receptor (GR) antagonizes induction of inflammatory genes via a novel combinatorial mechanism involving MKP-1-mediated AP-1 inhibition and GR/GRIP1 recruitment to the p65 DNA complex.

Minh-Ha T. Do, Sharon J. Santos, and Mark A. Lawson

GNRH Induces the Unfolded Protein Response in the LβT2 Pituitary Gonadotrope Cell Line
Mol Endocrinol 2009 23: 100-112, doi:10.1210/me.2008-0071 [Abstract] [Full Text] [PDF] [Supplemental Data]  
Gonadotropin-releasing hormone activates endoplasmic reticulum-resident stress sensors, causing a transient pause in translation and redistribution specific mRNAs, including those encoding gonadotropin subunits.

Joseph J. Shen, Lihua Huang, Liunan Li, Carolina Jorgez, Martin M. Matzuk, and Chester W. Brown

Deficiency of Growth Differentiation Factor 3 Protects against Diet-Induced Obesity by Selectively Acting on White Adipose
Mol Endocrinol 2009 23: 113-123, doi:10.1210/me.2007-0322 [Abstract] [Full Text] [PDF] [Supplemental Data]  
GDF3 is a TGF beta superfamliy member expressed in white adipose. Gdf3-/- mice are resistant to diet-induced obesity due to effects on the metabolic rate.

TRANSLATIONAL HIGHLIGHTS FROM JCEM:

Salama A. Salama, Marwa W. Kamel, Concepcion R. Diaz-Arrastia, Xia Xu, Timothy D. Veenstra, Sana Salih, Shaleen K. Botting, and Raj Kumar

Effect of TNF- on Estrogen Metabolism and Endometrial Cells: Potential Physiological and Pathological Relevance
Mol Endocrinol 2009 23: 124 [Full Text] [PDF]  

Charles C. Chung, Lawrence Shimmin, Sivamani Natarajan, Craig L. Hanis, Eric Boerwinkle, and James E. Hixson

Glucocorticoid Receptor Gene Variant in the 3' Untranslated Region Is Associated with Multiple Measures of Blood Pressure
Mol Endocrinol 2009 23: 124-125 [Full Text] [PDF]  

Erkut Attar, Hideki Tokunaga, Gonca Imir, M. Bertan Yilmaz, David Redwine, Michael Putman, Bilgin Gurates, Rukset Attar, Nobuo Yaegashi, Dale B. Hales, and Serdar E. Bulun

Prostaglandin E₂ via Steroidogenic Factor-1 Coordinately Regulates Transcription of Steroidogenic Genes Necessary for Estrogen Synthesis in Endometriosis
Mol Endocrinol 2009 23: 125 [Full Text] [PDF]  

Sara Bruce, Katariina Hannula-Jouppi, Jari Peltonen, Juha Kere, and Marita Lipsanen-Nyman

Clinically Distinct Epigenetic Subgroups in Silver-Russell Syndrome: The Degree of H19 Hypomethylation Associates with SRS Phenotype Severity and Genital and Skeletal Anomalies
Mol Endocrinol 2009 23: 125-126 [Full Text] [PDF]  

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