SPECIAL FEATURE:

Chiara Gabbi, Margaret Warner, and Jan-Åke Gustafsson

Minireview: Liver X Receptor β: Emerging Roles in Physiology and Diseases
Mol Endocrinol 2009 23: 129-136, doi:10.1210/me.2008-0398 [Abstract] [Full Text] [PDF]  
Studies on the phenotype of LXRβ–/– mice have revealed important roles for LXRβ in controlling not only lipid metabolism but also water transport.

ORIGINAL RESEARCH:

Lisheng Zhang, Xiongfei Huang, Zhipeng Meng, Bingning Dong, Steven Shiah, David D. Moore, and Wendong Huang

Significance and Mechanism of CYP7a1 Gene Regulation during the Acute Phase of Liver Regeneration
Mol Endocrinol 2009 23: 137-145, doi:10.1210/me.2008-0198 [Abstract] [Full Text] [PDF]  
Suppression of CYP7a1 gene expression is important to prevent liver injury during liver regeneration. CYP7a1 expression is regulated by different mechanisms during liver regeneration.

GuangFeng Zhang, Xuwan Liu, Adam M. Farkas, Anil V. Parwani, Kira L. Lathrop, Diana Lenzner, Stephanie R. Land, and Harish Srinivas

Estrogen Receptor β Functions through Nongenomic Mechanisms in Lung Cancer Cells
Mol Endocrinol 2009 23: 146-156, doi:10.1210/me.2008-0431 [Abstract] [Full Text] [PDF] [Supplemental Data]  
Estrogenic signaling in lung cancer cells is mediated through ERβ, but not ER, and functions through non-genomic mechanisms.

Jo Ann Janovick, Akshay Patny, Ralph Mosley, Mark T. Goulet, Michael D. Altman, Thomas S. Rush, III, Anda Cornea, and P. Michael Conn

Molecular Mechanism of Action of Pharmacoperone Rescue of Misrouted GPCR Mutants: The GnRH Receptor
Mol Endocrinol 2009 23: 157-168, doi:10.1210/me.2008-0384 [Abstract] [Full Text] [PDF]  
Computational modeling, site-directed mutagenesis, ligand binding, effector activation and confocal microscopy are used to show the molecular mechanism of pharmacoperone action on a GPCR, the hGnRHR.

Kenichi Miyako, Laura J. Cobb, Malik Francis, Alden Huang, Bonnie Peng, John E. Pintar, Hiroyoshi Ariga, and Pinchas Cohen

PAPA-1 Is a Nuclear Binding Partner of IGFBP-2 and Modulates Its Growth-Promoting Actions
Mol Endocrinol 2009 23: 169-175, doi:10.1210/me.2008-0168 [Abstract] [Full Text] [PDF]  
The growth inhibitory transcription factor PAPA-1 is shown to be a binding partner for IGFBP-2, which acts as a prostate cancer growth promoter.

Bhuvaneswari Ramaswamy, Sarmila Majumder, Satavisha Roy, Kalpana Ghoshal, Huban Kutay, Jharna Datta, Mamoun Younes, Charles L. Shapiro, Tasneem Motiwala, and Samson T. Jacob

Estrogen-Mediated Suppression of the Gene Encoding Protein Tyrosine Phosphatase PTPRO in Human Breast Cancer: Mechanism and Role in Tamoxifen Sensitivity
Mol Endocrinol 2009 23: 176-187, doi:10.1210/me.2008-0211 [Abstract] [Full Text] [PDF]  
This study demonstrates methylation-mediated suppression of protein tyrosine phosphatase PTPRO gene in primary breast cancer and provides a novel mechanism for its regulation by estradiol.

Rachid Safi, Garrett G. Muramoto, Alice B. Salter, Sarah Meadows, Heather Himburg, Lauren Russell, Pamela Daher, Phuong Doan, Mark D. Leibowitz, Nelson J. Chao, Donald P. McDonnell, and John P. Chute

Pharmacological Manipulation of the RAR/RXR Signaling Pathway Maintains the Repopulating Capacity of Hematopoietic Stem Cells in Culture
Mol Endocrinol 2009 23: 188-201, doi:10.1210/me.2008-0121 [Abstract] [Full Text] [PDF]  
The RAR/RXR heterodimer is a critical regulator of human HSC differentiation and pharmacologic modulation of RXR signaling sustains human HSCs in culture despite cytokine-induced proliferation.

Timothy M. Piazza, Juu-Chin Lu, Kristopher C. Carver, and Linda A. Schuler

Src Family Kinases Accelerate Prolactin Receptor Internalization, Modulating Trafficking and Signaling in Breast Cancer Cells
Mol Endocrinol 2009 23: 202-212, doi:10.1210/me.2008-0341 [Abstract] [Full Text] [PDF] [Supplemental Data]  
Src family kinases are key mediators of ligand-initiated prolactin receptor internalization, down-regulation, and signal transduction in MCF-7 breast cancer cells.

Qiuping Ma, Wei Fu, Pengfei Li, Santo V. Nicosia, Guido Jenster, Xiaohong Zhang, and Wenlong Bai

FoxO1 Mediates PTEN Suppression of Androgen Receptor N- and C-Terminal Interactions and Coactivator Recruitment
Mol Endocrinol 2009 23: 213-225, doi:10.1210/me.2008-0147 [Abstract] [Full Text] [PDF]  
The studies establish nuclear FoxO factors as mediators of the inhibition of AR N/C interaction and coactivator recruitment by the PTEN tumor suppressor.

Changhui Deng, Eric Ueda, KuanHui E. Chen, Craig Bula, Anthony W. Norman, Richard A. Luben, and Ameae M. Walker

Prolactin Blocks Nuclear Translocation of VDR by Regulating Its Interaction with BRCA1 in Osteosarcoma Cells
Mol Endocrinol 2009 23: 226-236, doi:10.1210/me.2008-0075 [Abstract] [Full Text] [PDF] [Supplemental Data]  
A BRCA1-vitamin D receptor (VDR) complex is undone by prolactin and required for VDR nuclear accumulation and 1,25 dihydroxyvitamin D3 functionality in osteosarcoma cells.

Heidi E. Walsh and Margaret A. Shupnik

Proteasome Regulation of Dynamic Transcription Factor Occupancy on the GnRH-Stimulated Luteinizing Hormone β-Subunit Promoter
Mol Endocrinol 2009 23: 237-250, doi:10.1210/me.2008-0098 [Abstract] [Full Text] [PDF]  
Proteasome activity is required for GnRH-stimulated LHβ transcription and cyclic promoter occupancy by Egr-1 and SF-1, two targets of the ubiquitin-proteasome pathway in gonadotropes.

Ji Young Kim, You Lee Son, and Young Chul Lee

Involvement of SMRT Corepressor in Transcriptional Repression by the Vitamin D Receptor
Mol Endocrinol 2009 23: 251-264, doi:10.1210/me.2008-0426 [Abstract] [Full Text] [PDF]  
The SMRT corepressor is directly involved in the VDR-mediated repression of target genes in vivo via a specific interaction between SMRT-ID1 and the VDR.

ANNOUNCEMENTS AND RESOURCES:

Chemical Approaches to Nuclear Receptors and Metabolism April 16–17, 2009 Bethesda, Maryland
Mol Endocrinol 2009 23: 250 [Full Text] [PDF]  

RESEARCH RESOURCE:

E. Maria C. Ohlsson Teague, Kylie H. Van der Hoek, Mark B. Van der Hoek, Naomi Perry, Prabhath Wagaarachchi, Sarah A. Robertson, Cristin G. Print, and Louise M. Hull

MicroRNA-Regulated Pathways Associated with Endometriosis
Mol Endocrinol 2009 23: 265-275, doi:10.1210/me.2008-0387 [Abstract] [Full Text] [PDF] [Supplemental Data]  
This study uses microarray technology, qRT-PCR and in silico analyses, to identify miRNA-regulated molecular pathways that are likely to contribute to the pathogenesis of endometriosis.

TRANSLATIONAL HIGHLIGHTS FROM JCEM:

Bert Delvoux, Patrick Groothuis, Thomas D'Hooghe, Cleophas Kyama, Gerard Dunselman, and Andrea Romano

Increased Production of 17β-Estradiol in Endometriosis Lesions is The Result of Impaired Metabolism
Mol Endocrinol 2009 23: 276 [Full Text] [PDF]  

En-Pei Isabel Chiang, Yi-Cheng Wang, Wei-Wen Chen, and Feng-Yao Tang

Effects of Insulin and Glucose on Cellular Metabolic Fluxes in Homocysteine Transsulfuration, Remethylation, S-Adenosylmethionine Synthesis and Global DNA Methylation
Mol Endocrinol 2009 23: 276-277 [Full Text] [PDF]  

Anoma Nellore, Karolina Paziana, Changqing Ma, Oxana M. Tsygankova, Yan Wang, Kanchan Puttaswamy, Ammarah U. Iqbal, Susanna R. Franks, Yu Lv, Andrea B. Troxel, Michael D. Feldman, Judy L. Meinkoth, and Marcia S. Brose

Loss of Rap1GAP in Papillary Thyroid Cancer
Mol Endocrinol 2009 23: 277 [Full Text] [PDF]  

Berit Kriström, Anna-Maija Zdunek, Anders Rydh, Håkan Jonsson, Petra Sehlin, and Stefan A. Escher

A Novel Mutation in The LHX3 Gene is Responsible for Combined Pituitary Hormone Deficiency, Hearing Impairment, and Vertebral Malformations
Mol Endocrinol 2009 23: 277 [Full Text] [PDF]  

Jin Yeong Kim, Haengseok Song, Hyunjoo Kim, Hee Jung Kang, Jin Hyun Jun, Sung Ran Hong, Mi Kyoung Koong, and In Sun Kim

Transcriptional Profiling with A Pathway-Oriented Analysis Identifies Dysregulated Molecular Phenotypes in The Endometrium of Patients with Polycystic Ovary Syndrome
Mol Endocrinol 2009 23: 278 [Full Text] [PDF]  

Karsten Müssig, Harald Staiger, Fausto Machicao, Alena Stancáková, Johanna Kuusisto, Markku Laakso, Claus Thamer, Jürgen Machann, Fritz Schick, Claus D. Claussen, Norbert Stefan, Andreas Fritsche, and Hans-Ulrich Häring

Association of Common Genetic Variation in The FOXO1 Gene with β-Cell Dysfunction, Impaired Glucose Tolerance, And Type 2 Diabetes
Mol Endocrinol 2009 23: 278-279 [Full Text] [PDF]  

Tomoko Kitagawa, Ken-Ichi Matsuda, Shigeki Inui, Hideya Takenaka, Norito Katoh, Satoshi Itami, Saburo Kishimoto, and Mitsuhiro Kawata

Keratinocyte Growth Inhibition through The Modification of Wnt Signaling by Androgen in Balding Dermal Papilla Cells
Mol Endocrinol 2009 23: 279 [Full Text] [PDF]  

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