SPECIAL FEATURE:

Karolien De Bosscher and Guy Haegeman

Minireview: Latest Perspectives on Antiinflammatory Actions of Glucocorticoids
Mol Endocrinol 2009 23: 281-291, doi:10.1210/me.2008-0283 [Abstract] [Full Text] [PDF]  
A number of recent advances are discussed regarding various anti-inflammatory mechanisms that are mediated by the glucocorticoid receptor.

ORIGINAL RESEARCH:

Sanna Kaikkonen, Tiina Jääskeläinen, Ulla Karvonen, Miia M. Rytinki, Harri Makkonen, Daniel Gioeli, Bryce M. Paschal, and Jorma J. Palvimo

SUMO-Specific Protease 1 (SENP1) Reverses the Hormone-Augmented SUMOylation of Androgen Receptor and Modulates Gene Responses in Prostate Cancer Cells
Mol Endocrinol 2009 23: 292-307, doi:10.1210/me.2008-0219 [Abstract] [Full Text] [PDF]  
SENP1 functions as a promoter selective coactivator for androgen receptor by deconjugating SUMO (small ubiquitin-related modifier) from the receptor in prostate cancer cells.

O. Araki, H. Ying, X. G. Zhu, M. C. Willingham, and S. Y. Cheng

Distinct Dysregulation of Lipid Metabolism by Unliganded Thyroid Hormone Receptor Isoforms
Mol Endocrinol 2009 23: 308-315, doi:10.1210/me.2008-0311 [Abstract] [Full Text] [PDF]  
Apo-TRβ and apo-TR1 have distinct effects on lipid metabolism and that TR isoforms differentially contribute to the pathogenesis of lipid metabolism in hypothyroidism.

Albina Jablonka-Shariff and Irving Boime

Secretory Trafficking Signal Encoded in the Carboxyl-Terminal Region of the CGβ-Subunit
Mol Endocrinol 2009 23: 316-323, doi:10.1210/me.2008-0351 [Abstract] [Full Text] [PDF]  
Truncation of the carboxyl end CGβ reveals sorting activity analogous to LH, supporting the hypothesis that LH/CG evolution resulted in altered secretory signals.

Laura A. Crawford, Michelle A. Guney, Young Ah Oh, R. Andrea DeYoung, David M. Valenzuela, Andrew J. Murphy, George D. Yancopoulos, Karen M. Lyons, David R. Brigstock, Aris Economides, and Maureen Gannon

Connective Tissue Growth Factor (CTGF) Inactivation Leads to Defects in Islet Cell Lineage Allocation and β-Cell Proliferation during Embryogenesis
Mol Endocrinol 2009 23: 324-336, doi:10.1210/me.2008-0045 [Abstract] [Full Text] [PDF] [Supplemental Data]  
Global gene inactivation reveals that connective tissue growth factor (CTGF) is required for pancreatic endocrine lineage allocation, embryonic β-cell proliferation, and islet morphogenesis.

Anat Ben-Shlomo, Cuiqi Zhou, Oxana Pichurin, Vera Chesnokova, Ning-Ai Liu, Michael D. Culler, and Shlomo Melmed

Constitutive Somatostatin Receptor Activity Determines Tonic Pituitary Cell Response
Mol Endocrinol 2009 23: 337-348, doi:10.1210/me.2008-0361 [Abstract] [Full Text] [PDF]  
Somatostatin receptors SST2 and SST5 constitutively regulate pituitary cell cAMP and ACTH in the absence of SRIF ligands.

Sekoni D. Noel, Kim L. Keen, David I. Baumann, Edward J. Filardo, and Ei Terasawa

Involvement of G Protein-Coupled Receptor 30 (GPR30) in Rapid Action of Estrogen in Primate LHRH Neurons
Mol Endocrinol 2009 23: 349-359, doi:10.1210/me.2008-0299 [Abstract] [Full Text] [PDF]  
Estradiol induces a rapid excitatory effect in primate LHRH neurons and GPR30 plays a role in mediating the rapid excitatory action.

Yuhong Wei, Svetlana Puzhko, Martin Wabitsch, and Cynthia Gates Goodyer

Structure and Activity of the Human Growth Hormone Receptor (hGHR) Gene V2 Promoter
Mol Endocrinol 2009 23: 360-372, doi:10.1210/me.2008-0188 [Abstract] [Full Text] [PDF] [Supplemental Data]  
Proximal promoter and 5'UTR exon domains regulate expression of V2, the major ubiquitously expressed transcript of the human growth hormone receptor gene in all tissues.

Yuhong Wei, Svetlana Puzhko, Martin Wabitsch, and Cynthia Gates Goodyer

Transcriptional Regulation of the Human Growth Hormone Receptor (hGHR) Gene V2 Promoter by Transcriptional Activators and Repressor
Mol Endocrinol 2009 23: 373-387, doi:10.1210/me.2008-0190 [Abstract] [Full Text] [PDF] [Supplemental Data]  
Specific stimulatory and inhibitory cis-elements regulate expression of V2, the major ubiquitously expressed transcript of the human growth hormone receptor gene in all tissues.

Suzanne E. Wardell, Olga R. Ilkayeva, Heather L. Wieman, Daniel E. Frigo, Jeffrey C. Rathmell, Christopher B. Newgard, and Donald P. McDonnell

Glucose Metabolism as a Target of Histone Deacetylase Inhibitors
Mol Endocrinol 2009 23: 388-401, doi:10.1210/me.2008-0179 [Abstract] [Full Text] [PDF] [Supplemental Data]  
The apoptotic activity of HDAC inhibitors is due in part to their ability to inhibit β-oxidation of fatty acids, glucose uptake and hexokinase activity.

Travis B. Salisbury, April K. Binder, Jean C. Grammer, and John H. Nilson

GnRH-Regulated Expression of Jun and JUN Target Genes in Gonadotropes Requires a Functional Interaction between TCF/LEF Family Members and β-Catenin
Mol Endocrinol 2009 23: 402-411, doi:10.1210/me.2008-0370 [Abstract] [Full Text] [PDF]  
A functional interaction between TCF/LEF proteins and β-catenin mediates GnRH regulated expression of Jun and downstream targets of JUN in gonadotropes.

Adena E. Rosenblatt and Kerry L. Burnstein

Inhibition of Androgen Receptor Transcriptional Activity as a Novel Mechanism of Action of Arsenic
Mol Endocrinol 2009 23: 412-421, doi:10.1210/me.2008-0235 [Abstract] [Full Text] [PDF]  
Arsenic, an environmental toxin and chemotherapeutic agent, inhibits androgen receptor transcriptional activity by disrupting androgen receptor recruitment to target gene promoters in chromatin

TRANSLATIONAL HIGHLIGHTS FROM JCEM:

Marianne S. Elston, Anthony J. Gill, John V. Conaglen, Adele Clarkson, Raymond J. Cook, Nicholas S. Little, Bruce G. Robinson, Roderick J. Clifton-Bligh, and Kerrie L. McDonald

Nuclear Accumulation of E-Cadherin Correlates with Loss of Cytoplasmic Membrane Staining and Invasion in Pituitary Adenomas
Mol Endocrinol 2009 23: 422 [Full Text] [PDF]  

Eléonore Maury, Laurence Noël, Roger Detry, and Sonia M. Brichard

In Vitro Hyperresponsiveness to Tumor Necrosis Factor- Contributes to Adipokine Dysregulation in Omental Adipocytes of Obese Subjects
Mol Endocrinol 2009 23: 422 [Full Text] [PDF]  

ANNOUNCEMENTS AND RESOURCES:

Erratum
Mol Endocrinol 2009 23: 423 [Full Text] [PDF]  

To see an article, click its [Full Text] link. To review many abstracts, check the boxes to the left of the titles you want, and click the 'Get All Checked Abstract(s)' button. To see one abstract at a time, click its [Abstract] link.