SPECIAL FEATURE:

Young-Ho Lee and Michael R. Stallcup

Minireview: Protein Arginine Methylation of Nonhistone Proteins in Transcriptional Regulation
Mol Endocrinol 2009 23: 425-433, doi:10.1210/me.2008-0380 [Abstract] [Full Text] [PDF]  
This review focuses on the increasingly recognized roles of arginine methylation of non-histone proteins in regulating transcription.

ORIGINAL RESEARCH:

Xuefen Xie, Hailing Liao, Huaixin Dang, Wei Pang, Youfei Guan, Xian Wang, John Y.-J. Shyy, Yi Zhu, and Frances M. Sladek

Down-Regulation of Hepatic HNF4 Gene Expression during Hyperinsulinemia via SREBPs
Mol Endocrinol 2009 23: 434-443, doi:10.1210/me.2007-0531 [Abstract] [Full Text] [PDF] [Supplemental Data]  
Hyperinsulinemia results in down regulation of HNF4 gene expression in the liver via SREBPs, which could contribute to hepatic steatosis (fatty liver) during diabetes.

Saleh Altuwaijri, Kuang-Hsiang Chuang, Kuo-Pao Lai, Jiann-Jyh Lai, Hung-Yun Lin, Faith M. Young, Andrea Bottaro, Meng-Yin Tsai, Wei-Ping Zeng, Hong-Chiang Chang, Shuyuan Yeh, and Chawnshang Chang

Susceptibility to Autoimmunity and B Cell Resistance to Apoptosis in Mice Lacking Androgen Receptor in B Cells
Mol Endocrinol 2009 23: 444-453, doi:10.1210/me.2008-0106 [Abstract] [Full Text] [PDF]  
Loss of B cells androgen receptor in mice results in increased blood/bone marrow B cells demonstrating a role for androgen/AR in B cell homeostasis/tolerance.

F. De Amicis, S. Zupo, M. L. Panno, R. Malivindi, F. Giordano, I. Barone, L. Mauro, S. A. W. Fuqua, and S. Andò

Progesterone Receptor B Recruits a Repressor Complex to a Half-PRE Site of the Estrogen Receptor Gene Promoter
Mol Endocrinol 2009 23: 454-465, doi:10.1210/me.2008-0267 [Abstract] [Full Text] [PDF]  
Estradiol induced up-regulation of progesterone receptor B plays a crucial role in the persistent decrease of estrogen receptor in breast cancer cells.

Kang Ho Kim, Jeong Min Yoon, A Hyun Choi, Woo Sik Kim, Gha Young Lee, and Jae Bum Kim

Liver X Receptor Ligands Suppress Ubiquitination and Degradation of LXR by Displacing BARD1/BRCA1
Mol Endocrinol 2009 23: 466-474, doi:10.1210/me.2008-0295 [Abstract] [Full Text] [PDF] [Supplemental Data]  
Liver X receptor ligands stabilize LXR protein by preventing LXR ubiquitination through dissociation of BARD1/BRCA1 complex, a novel ubiquitin E3-ligase of LXR.

Keyong Du and Jixin Ding

Insulin Regulates TRB3 and Other Stress-Responsive Gene Expression through Induction of C/EBPβ
Mol Endocrinol 2009 23: 475-485, doi:10.1210/me.2008-0284 [Abstract] [Full Text] [PDF] [Supplemental Data]  
The expression of metabolic stress responsive genes is associated with insulin action and modulates insulin signaling.

Xiangdong Wang, Ning Yang, Luqin Deng, Xin Li, Jing Jiang, Yujun Gan, and Stuart J. Frank

Interruption of Growth Hormone Signaling via SHC and ERK in 3T3-F442A Preadipocytes upon Knockdown of Insulin Receptor Substrate-1
Mol Endocrinol 2009 23: 486-496, doi:10.1210/me.2008-0407 [Abstract] [Full Text] [PDF]  
Deletion of insulin receptor substrate-1 (IRS-1) in 3T3-F442A cells results in markedly reduced GH-induced SHC and ERK signaling, suggesting IRS-1’s importance in this pathway.

Haichuan Duan, Nadia Cherradi, Jean-Jacques Feige, and Colin Jefcoate

cAMP-Dependent Posttranscriptional Regulation of Steroidogenic Acute Regulatory (STAR) Protein by the Zinc Finger Protein ZFP36L1/TIS11b
Mol Endocrinol 2009 23: 497-509, doi:10.1210/me.2008-0296 [Abstract] [Full Text] [PDF]  
Induction of STAR 3.5 kb mRNA by cAMP in steroidogenic cells is regulated post-transcriptionally by co-stimulation of ZFP36L1/TIS11b which binds elements in the extended 3'UTR.

Stephen Paul Armstrong, Christopher James Caunt, and Craig Alexander McArdle

Gonadotropin-Releasing Hormone and Protein Kinase C Signaling to ERK: Spatiotemporal Regulation of ERK by Docking Domains and Dual-Specificity Phosphatases
Mol Endocrinol 2009 23: 510-519, doi:10.1210/me.2008-0333 [Abstract] [Full Text] [PDF] [Supplemental Data]  
GnRH receptors mediate transient ERK activation in HeLa cells. This response is shaped by protein neosynthesis, D-domain-dependent binding and by phosphatases of each DUSP class.

Martina Zikova, Alicia Corlett, Zdenka Bendova, Petr Pajer, and Petr Bartunek

DISP3, a Sterol-Sensing Domain-Containing Protein that Links Thyroid Hormone Action and Cholesterol Metabolism
Mol Endocrinol 2009 23: 520-528, doi:10.1210/me.2008-0271 [Abstract] [Full Text] [PDF] [Supplemental Data]  
Dispatched 3 is a new thyroid hormone receptor-regulated gene that is expressed in neural tissues and modulates both the amount and distribution of cellular cholesterol.

Sabrina Semprini, Sonke Friedrichsen, Claire V. Harper, Judith R. McNeilly, Antony D. Adamson, David G. Spiller, Nina Kotelevtseva, Gillian Brooker, David G. Brownstein, Alan S. McNeilly, Michael R. H. White, Julian R. E. Davis, and John J. Mullins

Real-Time Visualization of Human Prolactin Alternate Promoter Usage in Vivo Using a Double-Transgenic Rat Model
Mol Endocrinol 2009 23: 529-538, doi:10.1210/me.2008-0399 [Abstract] [Full Text] [PDF] [Supplemental Data]  
Reporter-gene transgenic rats have been generated that provide the first in vivo model to accurately study the physiological regulation of the human prolactin gene.

Maree Bilandzic, Simon Chu, Paul G. Farnworth, Craig Harrison, Peter Nicholls, Yao Wang, Ruth M. Escalona, Peter J. Fuller, Jock K. Findlay, and Kaye L. Stenvers

Loss of Betaglycan Contributes to the Malignant Properties of Human Granulosa Tumor Cells
Mol Endocrinol 2009 23: 539-548, doi:10.1210/me.2008-0300 [Abstract] [Full Text] [PDF] [Supplemental Data]  
Betaglycan expression on human granulosa tumor cells decreases cellular invasion and wound healing and increases substrate adhesion, actions most strongly linked to its inhibin-binding ability.

Bin Dong and Fumio Matsumura

The Conversion of Rapid TCCD Nongenomic Signals to Persistent Inflammatory Effects via Select Protein Kinases in MCF10A Cells
Mol Endocrinol 2009 23: 549-558, doi:10.1210/me.2008-0317 [Abstract] [Full Text] [PDF]  
Long-lasting activation of protein kinases, e.g. PKA and Src, helps conversion of the initial nongenomic signaling of TCDD into chronic inflammatory effects in MCF10A cells.

Martina Kocan, Heng B. See, Natália G. Sampaio, Karin A. Eidne, Brian J. Feldman, and Kevin D. G. Pfleger

Agonist-Independent Interactions between β-Arrestins and Mutant Vasopressin Type II Receptors Associated with Nephrogenic Syndrome of Inappropriate Antidiuresis
Mol Endocrinol 2009 23: 559-571, doi:10.1210/me.2008-0321 [Abstract] [Full Text] [PDF]  
Using bioluminescence resonance energy transfer and confocal microscopy, V2R-R137C and V2R-R137L were shown to interact with β-arrestins in the absence of agonist resulting in dynamin-dependent internalization.

ANNOUNCEMENTS AND RESOURCES:

FASEB Summer Research Conference: Dynamic Structure of the Nuclear Hormone Receptors
Mol Endocrinol 2009 23: 485 [Full Text] [PDF]  

RESEARCH RESOURCE:

Hannelore V. Heemers, Kevin M. Regan, Lucy J. Schmidt, S. Keith Anderson, Karla V. Ballman, and Donald J. Tindall

Androgen Modulation of Coregulator Expression in Prostate Cancer Cells
Mol Endocrinol 2009 23: 572-583, doi:10.1210/me.2008-0363 [Abstract] [Full Text] [PDF] [Supplemental Data]  
Androgen control over coregulator expression in prostate cancer cells was demonstrated using a custom assay and revealed consequences for cell proliferation and androgen receptor activity.

TRANSLATIONAL HIGHLIGHTS FROM JCEM:

Mahesh Subramanian, Tania Pilli, Palash Bhattacharya, Furio Pacini, Yuri E. Nikiforov, Prasad V. Kanteti, and Bellur S. Prabhakar

Knockdown of IG20 Gene Expression Renders Thyroid Cancer Cells Susceptible to Apoptosis
Mol Endocrinol 2009 23: 584 [Full Text] [PDF]  

Marina Montagnani Marelli, Roberta M. Moretti, Stefania Mai, Joanna Januszkiewicz-Caulier, Marcella Motta, and Patrizia Limonta

Type I Gonadotropin-Releasing Hormone Receptor Mediates the Antiproliferative Effects of GnRH-II on Prostate Cancer Cells
Mol Endocrinol 2009 23: 584 [Full Text] [PDF]  

Anna V. Hoekstra, Elizabeth C. Sefton, Emily Berry, Zhenxiao Lu, Jennifer Hardt, Erica Marsh, Ping Yin, Jon Clardy, Debabrata Chakravarti, Serdar Bulun, and J. Julie Kim

Progestins Activate the AKT Pathway in Leiomyoma Cells and Promote Survival
Mol Endocrinol 2009 23: 585 [Full Text] [PDF]  

Peng Fang, I. David Schwartz, Betty D. Johnson, Michael A. Derr, Charles T. Roberts, Jr., Vivian Hwa, and Ron G. Rosenfeld

Familial Short Stature Caused by Haploinsufficiency of The Insulin-like Growth Factor 1 Receptor Due to Nonsense-Mediated mRNA Decay
Mol Endocrinol 2009 23: 585 [Full Text] [PDF]  

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