SPECIAL FEATURES:

Bert W. O'Malley

The "Fourth Dimension" of Gene Transcription
Mol Endocrinol 2009 23: 587-589, doi:10.1210/me.2009-0015 [Abstract] [Full Text] [PDF]  
The fastest running of all biological clocks may be the ’phospho-ubiquitin clock’ that regulates the functional lifetime of our genetic coactivator proteins.

Jean-Pierre Vilardaga, Moritz Bünemann, Timothy N. Feinstein, Nevin Lambert, Viacheslav O. Nikolaev, Stefan Engelhardt, Martin J. Lohse, and Carsten Hoffmann

Minireview: GPCR and G Proteins: Drug Efficacy and Activation in Live Cells
Mol Endocrinol 2009 23: 590-599, doi:10.1210/me.2008-0204 [Abstract] [Full Text] [PDF]  
GPCR studies in live cells have revealed kinetics and rate-limiting steps in receptor-mediated signaling, and have linked receptor polymorphisms and drug selectivity.

ORIGINAL RESEARCH:

Dongqing Wang, Xianmin Xia, Ying Liu, Alexis Oetting, Robert L. Walker, Yuelin Zhu, Paul Meltzer, Philip A. Cole, Yun-Bo Shi, and Paul M. Yen

Negative Regulation of TSH Target Gene by Thyroid Hormone Involves Histone Acetylation and Corepressor Complex Dissociation
Mol Endocrinol 2009 23: 600-609, doi:10.1210/me.2008-0389 [Abstract] [Full Text] [PDF] [Supplemental Data]  
The negative regulation of TSH gene transcription by thyroid hormone surprisingly occurs via histone H3 acetylation and loss of a corepressor/HDAC3 complex at its promoter.

Seunghee Lee, Dae-Hwan Kim, Young Hwa Goo, Young Chul Lee, Soo-Kyung Lee, and Jae W. Lee

Crucial Roles for Interactions between MLL3/4 and INI1 in Nuclear Receptor Transactivation
Mol Endocrinol 2009 23: 610-619, doi:10.1210/me.2008-0455 [Abstract] [Full Text] [PDF]  
Specific protein-protein interactions functionally connect two enzymatic entities in nuclear receptor transactivation, histone methyltransferase ASCOM and the ATPase-dependent chromatin remodeler Swi/Snf.

Soo Jung Lee, Christina Chae, and Michael M. Wang

p150/Glued Modifies Nuclear Estrogen Receptor Function
Mol Endocrinol 2009 23: 620-629, doi:10.1210/me.2007-0477 [Abstract] [Full Text] [PDF] [Supplemental Data]  
The p150/glued subunit of dynactin was shown to bind to and enhance the function of ER(), further linking the microtubule system to nuclear hormone function.

Juliette Rambaud, Gérard Triqueneaux, Ingrid Masse, Bart Staels, Vincent Laudet, and Gérard Benoit

Rev-erb2 mRNA Encodes a Stable Protein with a Potential Role in Circadian Clock Regulation
Mol Endocrinol 2009 23: 630-639, doi:10.1210/me.2008-0395 [Abstract] [Full Text] [PDF] [Supplemental Data]  
Coexpression and heterodimerisation of stable and unstable variants of the circadian clock protein REV-ERB ensure protein oscillation and provide a new potential clock regulatory mechanism.

Kamalesh K. Sharma, Zhu Wang, Daniel L. Motola, Carolyn L. Cummins, David J. Mangelsdorf, and Richard J. Auchus

Synthesis and Activity of Dafachronic Acid Ligands for the C. elegans DAF-12 Nuclear Hormone Receptor
Mol Endocrinol 2009 23: 640-648, doi:10.1210/me.2008-0415 [Abstract] [Full Text] [PDF] [Supplemental Data]  
The 4- 7-dafachronic acids are the most potent and biologically relevant isomers, due principally to A/B-ring structure. Comprehensive synthetic methods to multiple isomers are described.

Zhilin Liu, Michael D. Rudd, Inmaculata Hernandez-Gonzalez, Ignacio Gonzalez-Robayna, Heng-Yu Fan, Anthony J. Zeleznik, and JoAnne S. Richards

FSH and FOXO1 Regulate Genes in the Sterol/Steroid and Lipid Biosynthetic Pathways in Granulosa Cells
Mol Endocrinol 2009 23: 649-661, doi:10.1210/me.2008-0412 [Abstract] [Full Text] [PDF] [Erratum]  
FOXO1 may play a key role in granulosa cells to modulate lipid and sterol biosynthesis, thereby preventing elevated steroidogenesis during early stages of follicle development.

Sagar Ghosh, Ahsan Choudary, Sangeeta Ghosh, Nicolas Musi, Yanfen Hu, and Rong Li

IKKβ Mediates Cell Shape-Induced Aromatase Expression and Estrogen Biosynthesis in Adipose Stromal Cells
Mol Endocrinol 2009 23: 662-670, doi:10.1210/me.2008-0468 [Abstract] [Full Text] [PDF] [Supplemental Data]  
Cell shape change induces IKKβ-dependent aromatase transcription and estrogen biosynthesis in human adipose stromal cells.

Ting Wen, Bonnie Peng, and John E. Pintar

The MOR-1 Opioid Receptor Regulates Glucose Homeostasis by Modulating Insulin Secretion
Mol Endocrinol 2009 23: 671-678, doi:10.1210/me.2008-0345 [Abstract] [Full Text] [PDF]  
MOR-1 KO mice exhibit increased body mass compared to WT mice and also show enhanced glucose tolerance and insulin hypersecretion both in vivo and in vitro.

Gautam Rajpal, Ming Liu, Yi Zhang, and Peter Arvan

Single-Chain Insulins as Receptor Agonists
Mol Endocrinol 2009 23: 679-688, doi:10.1210/me.2008-0349 [Abstract] [Full Text] [PDF]  
A bioengineered C-peptide with -Gln-Arg- flanking sequences produces an uncleavable single-chain insulin with specific insulin receptor binding, metabolic signaling, and little cross-reactivity on IGF1 receptors.

Guoqing Hu, Elena A. Oboukhova, Sanjay Kumar, Michael Sturek, and Alexander G. Obukhov

Canonical Transient Receptor Potential Channels Expression Is Elevated in a Porcine Model of Metabolic Syndrome
Mol Endocrinol 2009 23: 689-699, doi:10.1210/me.2008-0350 [Abstract] [Full Text] [PDF] [Supplemental Data]  
TRPC channels’ expression is increased in the adrenal medulla of metabolic syndrome pigs. The involvement of elevated plasma aldosterone, a metabolic syndrome signature, is proposed.

Yi Ren, Robert G. Cowan, Rebecca M. Harman, and Susan M. Quirk

Dominant Activation of the Hedgehog Signaling Pathway in the Ovary Alters Theca Development and Prevents Ovulation
Mol Endocrinol 2009 23: 711-723, doi:10.1210/me.2008-0391 [Abstract] [Full Text] [PDF] [Supplemental Data]  
Overactivation of signaling through the hedgehog pathway in ovarian follicles of transgenic mice impairs development of muscle cells within the theca and prevents ovulation.

ARTICLES:

Maxime Sasseville, Marie-Claude Gagnon, Christine Guillemette, Robert Sullivan, Robert B. Gilchrist, and François J. Richard

Regulation of Gap Junctions in Porcine Cumulus-Oocyte Complexes: Contributions of Granulosa Cell Contact, Gonadotropins, and Lipid Rafts
Mol Endocrinol 2009 23: 700-710, doi:10.1210/me.2008-0320 [Abstract] [Full Text] [PDF] [Supplemental Data]  
Recovery of the cumulus-oocyte complex from the follicle induces an increased gap-junctional communication followed by a gonadotropin-dependant decrease involving Cx43 recruitment to the lipid raft.

RESEARCH RESOURCE:

Chang-Qing Xie, Yangsik Jeong, Mingui Fu, Angie L. Bookout, Minerva T. Garcia-Barrio, Tingwan Sun, Bong-hyun Kim, Yang Xie, Sierra Root, Jifeng Zhang, Ren-He Xu, Y. Eugene Chen, and David J. Mangelsdorf

Expression Profiling of Nuclear Receptors in Human and Mouse Embryonic Stem Cells
Mol Endocrinol 2009 23: 724-733, doi:10.1210/me.2008-0465 [Abstract] [Full Text] [PDF] [Supplemental Data]  
An atlas of nuclear receptor expression during early mouse and human embryonic stem cell differentiation demonstrates similarities and differences between species.

TRANSLATIONAL HIGHLIGHTS FROM JCEM:

Rebecca E. Schweppe, Anna A. Kerege, Jena D. French, Vibha Sharma, Rachel L. Grzywa, and Bryan R. Haugen

Inhibition of Src with AZD0530 Reveals the Src-Focal Adhesion Kinase Complex as a Novel Therapeutic Target in Papillary and Anaplastic Thyroid Cancers
Mol Endocrinol 2009 23: 734 [Full Text] [PDF]  

Mark B. Zimering and Zui Pan

Autoantibodies in Type 2 Diabetes Induce Stress Fiber Formation and Apoptosis in Endothelial Cells
Mol Endocrinol 2009 23: 734 [Full Text] [PDF]  

Niels Møller, Lars C. Gormsen, Ole Schmitz, Sten Lund, Jens Otto L. Jørgensen, and Niels Jessen

Free Fatty Acids Inhibit Growth Hormone/Signal Transducer and Activator of Transcription-5 Signaling in Human Muscle: A Potential Feedback Mechanism
Mol Endocrinol 2009 23: 735 [Full Text] [PDF]  

Kahina Boukari, Geri Meduri, Sylvie Brailly-Tabard, Jean Guibourdenche, Maria Luisa Ciampi, Nathalie Massin, Laetitia Martinerie, Jean-Yves Picard, Rodolfo Rey, Marc Lombès, and Jacques Young

Lack of Androgen Receptor Expression in Sertoli Cells accounts for the Absence of Anti-Mullerian Hormone Repression during Early Human Testis Development
Mol Endocrinol 2009 23: 735 [Full Text] [PDF]  

Mabrouka Doghman, Julie Cazareth, Dominique Douguet, Franck Madoux, Peter Hodder, and Enzo Lalli

Inhibition of Adrenocortical Carcinoma Cell Proliferation by Steroidogenic Factor-1 Inverse Agonists
Mol Endocrinol 2009 23: 736 [Full Text] [PDF]  

Akira Iwase, Maki Goto, Toko Harata, Sachiko Takigawa, Tatsuo Nakahara, Kyosuke Suzuki, Shuichi Manabe, and Fumitaka Kikkawa

Insulin Attenuates the Insulin-Like Growth Factor-I (IGF-I)-Akt Pathway, not IGF-I-Extracellularly Regulated Kinase Pathway, in Luteinized Granulosa Cells with an Increase in PTEN
Mol Endocrinol 2009 23: 736 [Full Text] [PDF]  

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