ARTICLES:

Neil J. McKenna and Donald B. DeFranco

Molecular Endocrinology: A Portal for Enhanced Access and Utility of the Nuclear Receptor Signaling Atlas (NURSA) Web Resource
Mol Endocrinol 2009 23: 739, doi:10.1210/me.2009-0169 [Full Text] [PDF]  

SPECIAL FEATURES:

Neil J. McKenna, Austin J. Cooney, Francesco J. DeMayo, Michael Downes, Christopher K. Glass, Rainer B. Lanz, Mitchell A. Lazar, David J. Mangelsdorf, David D. Moore, Jun Qin, David L. Steffen, Ming-Jer Tsai, Sophia Y. Tsai, Ruth Yu, Ronald N. Margolis, Ronald M. Evans, and Bert W. O'Malley

Minireview: Evolution of NURSA, the Nuclear Receptor Signaling Atlas
Mol Endocrinol 2009 23: 740-746, doi:10.1210/me.2009-0135 [Abstract] [Full Text] [PDF] [Erratum]  
The Nuclear Receptor Signaling Atlas (NURSA) Consortium is a team science-based effort to probe the role of nuclear receptors and coregulators in metabolic diseases and to distribute datasets via the internet.

Mira M. Sachdeva and Doris A. Stoffers

Minireview: Meeting the Demand for Insulin: Molecular Mechanisms of Adaptive Postnatal ß-Cell Mass Expansion
Mol Endocrinol 2009 23: 747-758, doi:10.1210/me.2008-0400 [Abstract] [Full Text] [PDF]  
This review addresses the molecular mechanisms underlying compensatory expansion of ß-cell mass in response to insulin resistance, the failure of which leads to diabetes.

ORIGINAL RESEARCH:

Nobumichi Ohoka, Shogo Kato, Yu Takahashi, Hidetoshi Hayashi, and Ryuichiro Sato

The Orphan Nuclear Receptor ROR Restrains Adipocyte Differentiation through a Reduction of C/EBPβ Activity and Perilipin Gene Expression
Mol Endocrinol 2009 23: 759-771, doi:10.1210/me.2008-0277 [Abstract] [Full Text] [PDF] [Supplemental Data]  
The orphan nuclear receptor ROR restrains adipocyte differentiation through a reduction of C/EBPβ activity and gene expression of lipid droplet-coating protein perilipin.

Dongyuan Liu, Houda Benlhabib, and Carole R. Mendelson

cAMP Enhances Estrogen-Related Receptor (ERR) Transcriptional Activity at the SP-A Promoter by Increasing Its Interaction with Protein Kinase A and Steroid Receptor Coactivator 2 (SRC-2)
Mol Endocrinol 2009 23: 772-783, doi:10.1210/me.2008-0282 [Abstract] [Full Text] [PDF]  
Cyclic AMP upregulation of SP-A promoter activity in lung type II cells is mediated by PKA-induced expression, phosphorylation and DNA binding of ERR.

Premlata Kumar, Amrita Kamat, and Carole R. Mendelson

Estrogen Receptor (ER) Mediates Stimulatory Effects of Estrogen on Aromatase (CYP19) Gene Expression in Human Placenta
Mol Endocrinol 2009 23: 784-793, doi:10.1210/me.2008-0371 [Abstract] [Full Text] [PDF]  
Estrogen/ER exert a positive feedback role on human trophoblast, which promotes differentiation and permissive histone modifications with induction of hCYP19 expression.

Anne Bugge, Lars Grøntved, Mads M. Aagaard, Rehannah Borup, and Susanne Mandrup

The PPAR2 A/B-Domain Plays a Gene-Specific Role in Transactivation and Cofactor Recruitment
Mol Endocrinol 2009 23: 794-808, doi:10.1210/me.2008-0236 [Abstract] [Full Text] [PDF] [Supplemental Data]  
The N-terminal domain of PPAR is specifically required for full activation of a subset of lipogenic target genes and for p300/CBP recruitment to associated target sites.

Ignacio Quiles, Lluís Millán-Ariño, Alicia Subtil-Rodríguez, Belén Miñana, Nora Spinedi, Cecilia Ballaré, Miguel Beato, and Albert Jordan

Mutational Analysis of Progesterone Receptor Functional Domains in Stable Cell Lines Delineates Sets of Genes Regulated by Different Mechanisms
Mol Endocrinol 2009 23: 809-826, doi:10.1210/me.2008-0454 [Abstract] [Full Text] [PDF] [Supplemental Data]  
Gene expression analysis in T47D cells stably expressing functionally deficient PR-B forms denotes the relevance of crosstalk between genomic and non-genomic receptor modes of action.

Preeti Ramadoss, Nathan E. Unger-Smith, Francis S. Lam, and Anthony N. Hollenberg

STAT3 Targets the Regulatory Regions of Gluconeogenic Genes in Vivo
Mol Endocrinol 2009 23: 827-837, doi:10.1210/me.2008-0264 [Abstract] [Full Text] [PDF]  
STAT3 interacts with the promoter regions of gluconeogenic genes in vivo and causes transcriptional repression.

Maria Giuseppina Baratta, Immacolata Porreca, and Roberto Di Lauro

Oncogenic Ras Blocks the cAMP Pathway and Dedifferentiates Thyroid Cells Via an Impairment of Pax8 Transcriptional Activity
Mol Endocrinol 2009 23: 838-848, doi:10.1210/me.2008-0353 [Abstract] [Full Text] [PDF]  
Oncogenic Ras induces dedifferentiation of cultured thyroid cells via an impairment of the cAMP/PKA pathway and a consequent inhibition of the transcription factor Pax8.

Nadiya M. Teplyuk, Ying Zhang, Yang Lou, John R. Hawse, Mohammad Q. Hassan, Viktor I. Teplyuk, Jitesh Pratap, Mario Galindo, Janet L. Stein, Gary S. Stein, Jane B. Lian, and Andre J. van Wijnen

The Osteogenic Transcription Factor Runx2 Controls Genes Involved in Sterol/Steroid Metabolism, Including Cyp11a1 in Osteoblasts
Mol Endocrinol 2009 23: 849-861, doi:10.1210/me.2008-0270 [Abstract] [Full Text] [PDF] [Supplemental Data]  
Runx2 directly regulates a program of genes for enzymes that biochemically convert sterols and steroid hormones during osteoblast growth and differentiation.

Marcos Rivas, Britt Mellström, Begoña Torres, Gaetano Cali, Alfonso M. Ferrara, Daniela Terracciano, Mariastella Zannini, Gabriella Morreale de Escobar, and Jose R. Naranjo

The DREAM Protein Is Associated with Thyroid Enlargement and Nodular Development
Mol Endocrinol 2009 23: 862-870, doi:10.1210/me.2008-0466 [Abstract] [Full Text] [PDF] [Supplemental Data]  
DREAM regulates TSHR activity and increased DREAM levels are associated with thyroid pathologies.

Shinichi Miyagawa, Yoshihiko Satoh, Ryuma Haraguchi, Kentaro Suzuki, Taisen Iguchi, Makoto M. Taketo, Naomi Nakagata, Takahiro Matsumoto, Ken-ichi Takeyama, Shigeaki Kato, and Gen Yamada

Genetic Interactions of the Androgen and Wnt/β-Catenin Pathways for the Masculinization of External Genitalia
Mol Endocrinol 2009 23: 871-880, doi:10.1210/me.2008-0478 [Abstract] [Full Text] [PDF]  
The Wnt/β-catenin pathway genetically interacts with the androgen signaling pathway and functions as a locally expressed masculine factor during male external genitalia formation.

Sandra M. Malakauskas, Wissam M. Kourany, Xiao Yin Zhang, Danhong Lu, Robert D. Stevens, Timothy R. Koves, Hans E. Hohmeier, Deborah M. Muoio, Christopher B. Newgard, and Thu H. Le

Increased Insulin Sensitivity in Mice Lacking Collectrin, a Downstream Target of HNF-1
Mol Endocrinol 2009 23: 881-892, doi:10.1210/me.2008-0274 [Abstract] [Full Text] [PDF]  
Targeted deletion of collectrin in mice results in enhanced insulin sensitivity with age that is associated with upregulation of oxidative metabolism and decreased adiposity.

Thomas M. Reinbothe, Rosita Ivarsson, Dai-Qing Li, Omid Niazi, Xingjun Jing, Enming Zhang, Lena Stenson, Ulrika Bryborn, and Erik Renström

Glutaredoxin-1 Mediates NADPH-Dependent Stimulation of Calcium-Dependent Insulin Secretion
Mol Endocrinol 2009 23: 893-900, doi:10.1210/me.2008-0306 [Abstract] [Full Text] [PDF]  
The redox regulatory protein glutaredoxin-1 locates to the cellular membrane of β-cells and enhances insulin exocytosis through a local redox reaction with NADPH.

Siwei Li, Qian Wang, Yi Wang, Xinmei Chen, and Zhixiang Wang

PLC-1 and Rac1 Coregulate EGF-Induced Cytoskeleton Remodeling and Cell Migration
Mol Endocrinol 2009 23: 901-913, doi:10.1210/me.2008-0368 [Abstract] [Full Text] [PDF]  
PLC-1 binds to the Rac1 106PNTP109 motif and stimulates Rac1 activity acting as a GEF through its SH3 domain leading to regulation of EGF-induced cytoskeleton remodeling and cell migration.

Jeffrey S. Davies, Pia Kotokorpi, Sinan R. Eccles, Sarah K. Barnes, Pawel F. Tokarczuk, Sophie K. Allen, Hilary S. Whitworth, Irina A. Guschina, Bronwen A. J. Evans, Agneta Mode, Jeffrey M. Zigman, and Timothy Wells

Ghrelin Induces Abdominal Obesity Via GHS-R-Dependent Lipid Retention
Mol Endocrinol 2009 23: 914-924, doi:10.1210/me.2008-0432 [Abstract] [Full Text] [PDF]  
Circulating acylated ghrelin elevates fat mass in specific abdominal depots by a GHSR1a-dependent reduction in lipid export and an increase in adipocyte size.

Tingwan Sun, Mingui Fu, Angie L. Bookout, Steven A. Kliewer, and David J. Mangelsdorf

MicroRNA let-7 Regulates 3T3-L1 Adipogenesis
Mol Endocrinol 2009 23: 925-931, doi:10.1210/me.2008-0298 [Abstract] [Full Text] [PDF] [Supplemental Data][Corrigendum]  
A survey of microRNAs expressed during adipogenesis reveals let-7 as a key governor of adipocyte differentiation through its reciprocal regulation of the transcription factor HMGA2.

Fa-Xing Yu, Shuang-Ru Goh, Ru-Ping Dai, and Yan Luo

Adenosine-Containing Molecules Amplify Glucose Signaling and Enhance Txnip Expression
Mol Endocrinol 2009 23: 932-942, doi:10.1210/me.2008-0383 [Abstract] [Full Text] [PDF] [Supplemental Data]  
Adenosine-containing molecules induce Txnip expression via a carbohydrate response element (ChoRE) and the ChoRE-associated transcription factors MondoA and MLX in a glucose dependent manner.

ANNOUNCEMENTS AND RESOURCES:

CINCINNATI CANCER SYMPOSIUM SERIES
Mol Endocrinol 2009 23: 942 [Full Text] [PDF]  

TRANSLATIONAL HIGHLIGHTS FROM JCEM:

Matthias Blüher, Nava Bashan, Iris Shai, Ilana Harman-Boehm, Tanya Tarnovscki, Eliezer Avinaoch, Michael Stumvoll, Arne Dietrich, Nora Klöting, and Assaf Rudich

Activated Ask1-MKK4-p38MAPK/JNK Stress Signaling Pathway in Human Omental Fat Tissue May Link Macrophage Infiltration to Whole-Body Insulin Sensitivity
Mol Endocrinol 2009 23: 943 [Full Text] [PDF]  

Tim J. Craig, Kenju Shimomura, Reinhard W. Holl, Sarah E. Flanagan, Sian Ellard, and Frances M. Ashcroft

An In-Frame Deletion in Kir6.2 (KCNJ11) Causing Neonatal Diabetes Reveals a Site of Interaction between Kir6.2 and SUR1
Mol Endocrinol 2009 23: 943-944 [Full Text] [PDF]  

Manuela Vargiolu, Daniela Fusco, Ivana Kurelac, Dietmar Dirnberger, Ralf Baumeister, Isabella Morra, Antonio Melcarne, Roberto Rimondini, Giovanni Romeo, and Elena Bonora

The Tyrosine Kinase Receptor RET Interacts in Vivo with Aryl Hydrocarbon Receptor-Interacting Protein to Alter Survivin Availability
Mol Endocrinol 2009 23: 944 [Full Text] [PDF]  

Elizabeth A. Lawson, Xun Zhang, Jonathan T. Crocker, Wei-Lien Wang, and Anne Klibanski

Hypoglycemia from IGF2 Overexpression Associated with Activation of Fetal Promoters and Loss of Imprinting in a Metastatic Hemangiopericytoma
Mol Endocrinol 2009 23: 944 [Full Text] [PDF]  

Estelle Louiset, Constantine A. Stratakis, Véronique Perraudin, Kurt J. Griffin, Rossella Libé, Sylvie Cabrol, Bruno Fève, Jacques Young, Lionel Groussin, Jérôme Bertherat, and Hervé Lefebvre

The Paradoxical Increase in Cortisol Secretion Induced by Dexamethasone in Primary Pigmented Nodular Adrenocortical Disease Involves a Glucocorticoid Receptor-Mediated Effect of Dexamethasone on Protein Kinase A Catalytic Subunits
Mol Endocrinol 2009 23: 945 [Full Text] [PDF]  

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