SPECIAL FEATURE:

Felix Grün and Bruce Blumberg

Minireview: The Case for Obesogens
Mol Endocrinol 2009 23: 1127-1134, doi:10.1210/me.2008-0485 [Abstract] [Full Text] [PDF]  
Obesogens are chemicals that derail the body’s homeostatic weight control mechanisms, predisposing exposed individuals to weight gain despite normal diet and exercise.

ORIGINAL RESEARCH:

Pragati Katiyar, Yongxian Ma, Anna Riegel, Saijun Fan, and Eliot M. Rosen

Mechanism of BRCA1-Mediated Inhibition of Progesterone Receptor Transcriptional Activity
Mol Endocrinol 2009 23: 1135-1146, doi:10.1210/me.2008-0347 [Abstract] [Full Text] [PDF] [Supplemental Data]  
BRCA1 inhibits progesterone receptor (PR) activity by blocking recruitment of PR to a progesterone response element and promoting the formation of a corepressor rather than coactivator complex.

Xuesen Dong, Celeste Yu, Oksana Shynlova, John R. G. Challis, Paul S. Rennie, and Stephen J. Lye

p54nrb Is a Transcriptional Corepressor of the Progesterone Receptor that Modulates Transcription of the Labor-Associated Gene, Connexin 43 (Gja1)
Mol Endocrinol 2009 23: 1147-1160, doi:10.1210/me.2008-0357 [Abstract] [Full Text] [PDF] [Supplemental Data]  
The progesterone receptor (PR) co-repressor, p54nrb, contributes to the functional withdrawal of progesterone and the initiation of labor by de-repressing PR-mediated inhibition of Cx43 expression.

Chong Xu, Jinhan He, Hongfeng Jiang, Luxia Zu, Wenjie Zhai, Shenshen Pu, and Guoheng Xu

Direct Effect of Glucocorticoids on Lipolysis in Adipocytes
Mol Endocrinol 2009 23: 1161-1170, doi:10.1210/me.2008-0464 [Abstract] [Full Text] [PDF]  
The direct lipolysis action of glucocorticoids is mediated through PKA signaling in adipocytes and contributes to elevation of circulating free fatty acids in response to glucocorticoid challenge.

Linda L. Grasfeder, Stephanie Gaillard, Stephen R. Hammes, Olga Ilkayeva, Christopher B. Newgard, Richard B. Hochberg, Mary A. Dwyer, Ching-yi Chang, and Donald P. McDonnell

Fasting-Induced Hepatic Production of DHEA Is Regulated by PGC-1, ERR, and HNF4
Mol Endocrinol 2009 23: 1171-1182, doi:10.1210/me.2009-0024 [Abstract] [Full Text] [PDF] [Supplemental Data]  
PGC-1 regulates hepatic synthesis of DHEA by inducing expression of CYP11A1 and CYP17A1 through HNF4 and ERR. This study highlights hepatic DHEA production as a novel fasting response.

Meghan D. Rosen and Martin L. Privalsky

Thyroid Hormone Receptor Mutations Found in Renal Clear Cell Carcinomas Alter Corepressor Release and Reveal Helix 12 as Key Determinant of Corepressor Specificity
Mol Endocrinol 2009 23: 1183-1192, doi:10.1210/me.2009-0126 [Abstract] [Full Text] [PDF] [Supplemental Data]  
Thyroid hormone receptor mutants associated with human renal clear cell carcinoma display dominant-negative properties that correlate with alterations in their corepressor recruitment and specificity.

Angel Matias Sanchez, Marina Ines Flamini, Xiao-Dong Fu, Paolo Mannella, Maria Silvia Giretti, Lorenzo Goglia, Andrea Riccardo Genazzani, and Tommaso Simoncini

Rapid Signaling of Estrogen to WAVE1 and Moesin Controls Neuronal Spine Formation via the Actin Cytoskeleton
Mol Endocrinol 2009 23: 1193-1202, doi:10.1210/me.2008-0408 [Abstract] [Full Text] [PDF] [Supplemental Data]  
G protein-initiated extra-nuclear signaling of estrogen receptor- via WAVE1/Arp2/3 and the ERM protein moesin mediates estradiol effects on actin remodeling and spine formation in cortical neurons.

Sanjeev K. Baniwal, Omar Khalid, Donna Sir, Grant Buchanan, Gerhard A. Coetzee, and Baruch Frenkel

Repression of Runx2 by Androgen Receptor (AR) in Osteoblasts and Prostate Cancer Cells: AR Binds Runx2 and Abrogates Its Recruitment to DNA
Mol Endocrinol 2009 23: 1203-1214, doi:10.1210/me.2008-0470 [Abstract] [Full Text] [PDF] [Supplemental Data]  
AR directly interacts with Runx2 and inhibits its DNA-binding and transcriptional activity, potentially contributing to the bone-sparing and prostate carcinogenic properties of androgens.

Brian D. Adams, Danielle M. Cowee, and Bruce A. White

The Role of miR-206 in the Epidermal Growth Factor (EGF) Induced Repression of Estrogen Receptor- (ER) Signaling and a Luminal Phenotype in MCF-7 Breast Cancer Cells
Mol Endocrinol 2009 23: 1215-1230, doi:10.1210/me.2009-0062 [Abstract] [Full Text] [PDF] [Supplemental Data]  
MicroRNA-206 targets mRNAs encoding ER, SRC-1, SRC-3 and GATA-3, and contributes to the EGF-induced transition from a "Luminal" to a "Basal-like" subtype in breast cancer.

Ravi Jasuja, Jagadish Ulloor, Christopher M. Yengo, Karen Choong, Andrei Y. Istomin, Dennis R. Livesay, Donald J. Jacobs, Ronald S. Swerdloff, Jaroslava Miksovská, Randy W. Larsen, and Shalender Bhasin

Kinetic and Thermodynamic Characterization of Dihydrotestosterone-Induced Conformational Perturbations in Androgen Receptor Ligand-Binding Domain
Mol Endocrinol 2009 23: 1231-1241, doi:10.1210/me.2008-0304 [Abstract] [Full Text] [PDF]  
DHT binding leads to energetic stabilization of androgen receptor ligand binding domain (LBD) and rearrangement of residues distant from ligand binding pocket; this biphasic receptor rearrangement includes population of a molten globule-like intermediate state.

Ekaterina V. Laz, Aarathi Sugathan, and David J. Waxman

Dynamic in Vivo Binding of STAT5 to Growth Hormone-Regulated Genes in Intact Rat Liver. Sex-Specific Binding at Low- But Not High-Affinity STAT5 Sites
Mol Endocrinol 2009 23: 1242-1254, doi:10.1210/me.2008-0449 [Abstract] [Full Text] [PDF] [Supplemental Data]  
STAT5 binds to chromatin dynamically in male liver, cycling on/off with plasma GH pulses. Sex-specific binding is apparent at low but not high-affinity STAT5 sites.

Christine E. Boumah, Minnkyong Lee, Nagarajan Selvamurugan, Emi Shimizu, and Nicola C. Partridge

Runx2 Recruits p300 to Mediate Parathyroid Hormone’s Effects on Histone Acetylation and Transcriptional Activation of the Matrix Metalloproteinase-13 Gene
Mol Endocrinol 2009 23: 1255-1263, doi:10.1210/me.2008-0217 [Abstract] [Full Text] [PDF]  
PTH stimulates histone acetylation via recruitment of p300 to Runx2 bound to the MMP-13 promoter, resulting in gene activation.

Géraldine Parnaud, Eva Hammar, Pascale Ribaux, Marc Y. Donath, Thierry Berney, and Philippe A. Halban

Signaling Pathways Implicated in the Stimulation of β-Cell Proliferation by Extracellular Matrix
Mol Endocrinol 2009 23: 1264-1271, doi:10.1210/me.2009-0008 [Abstract] [Full Text] [PDF]  
Extracellular matrix increases proliferation of rat pancreatic beta cells in a glucose-dependent fashion by raising cytosolic Ca²⁺ and activating the transcription factors NFAT and NF-B.

Jonathon M. Willets, Paul J. Brighton, Rajendra Mistry, Gavin E. Morris, Justin C. Konje, and R. A. John Challiss

Regulation of Oxytocin Receptor Responsiveness by G Protein-Coupled Receptor Kinase 6 in Human Myometrial Smooth Muscle
Mol Endocrinol 2009 23: 1272-1280, doi:10.1210/me.2009-0047 [Abstract] [Full Text] [PDF] [Supplemental Data]  
G protein-coupled receptor kinase type 6 (GRK6) selectively regulates oxytocin receptor responsiveness to agonist stimulation in a primary human myometrial cell background.

Takuma Kondo, Ilham El Khattabi, Wataru Nishimura, D. Ross Laybutt, Pedro Geraldes, Samit Shah, George King, Susan Bonner-Weir, Gordon Weir, and Arun Sharma

p38 MAPK Is a Major Regulator of MafA Protein Stability under Oxidative Stress
Mol Endocrinol 2009 23: 1281-1290, doi:10.1210/me.2008-0482 [Abstract] [Full Text] [PDF]  
Both p38 MAPK and GSK3 regulate MafA protein stability under normal culture conditions, but p38 MAPK is the predominant regulator of MafA stability under oxidative-stress.

Sakhila K. Banu, JeHoon Lee, V. O. Speights, Jr., Anna Starzinski-Powitz, and Joe A. Arosh

Selective Inhibition of Prostaglandin E2 Receptors EP2 and EP4 Induces Apoptosis of Human Endometriotic Cells through Suppression of ERK1/2, AKT, NFB, and β-Catenin Pathways and Activation of Intrinsic Apoptotic Mechanisms
Mol Endocrinol 2009 23: 1291-1305, doi:10.1210/me.2009-0017 [Abstract] [Full Text] [PDF]  
Selective blockade EP2 and EP4 receptors suppresses cell survival and activates intrinsic apoptotic pathways thereby inhibiting survival of human endometriotic epithelial and stromal cells.

TRANSLATIONAL HIGHLIGHTS FROM JCEM:

Marcela Julio-Pieper, Patricia Lozada, Veronica Tapia, Margarita Vega, Cristián Miranda, David Vantman, Sergio R. Ojeda, and Carmen Romero

Nerve Growth Factor Induces Vascular Endothelial Growth Factor Expression in Granulosa Cells via a trkA Receptor/Mitogen-Activated Protein Kinase-Extracellularly Regulated Kinase 2-Dependent Pathway
Mol Endocrinol 2009 23: 1306-1307 [Full Text] [PDF]  

Melania Pulcrano, Emiliano Palmieri, Deborah Mannavola, Irene Campi, Danila Covelli, Gaetano Lombardi, Bernadette Biondi, and Paolo Beck-Peccoz

Impact of Resistance to Thyroid Hormone on the Cardiovascular System in Adults
Mol Endocrinol 2009 23: 1306 [Full Text] [PDF]  

Kathleen M. Gavin, Douglas R. Seals, Annemarie E. Silver, and Kerrie L. Moreau

Vascular Endothelial Estrogen Receptor Is Modulated by Estrogen Status and Related to Endothelial Function and Endothelial Nitric Oxide Synthase in Healthy Women
Mol Endocrinol 2009 23: 1307 [Full Text] [PDF]  

Sowmya Surya, Jeffrey F. Horowitz, Naila Goldenberg, Alla Sakharova, Matthew Harber, Andrea S. Cornford, Kathy Symons, and Ariel L. Barkan

The Pattern of Growth Hormone Delivery to Peripheral Tissues Determines Insulin-Like Growth Factor-1 and Lipolytic Responses in Obese Subjects
Mol Endocrinol 2009 23: 1307 [Full Text] [PDF]  

THE ENDOCRINE SOCIETY:

The Endocrine Society Laureate Awards
Mol Endocrinol 2009 23: 1308-1309 [Full Text] [PDF]  

THE ENDOCRINE SOCIETY 2009 LAUREATE AWARDS
Mol Endocrinol 2009 23: 1310-1321 [Full Text] [PDF]  

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