SPECIAL FEATURE:

Susan C. Wu and Yi Zhang

Minireview: Role of Protein Methylation and Demethylation in Nuclear Hormone Signaling
Mol Endocrinol 2009 23: 1323-1334, doi:10.1210/me.2009-0131 [Abstract] [Full Text] [PDF]  
This review discusses recent advances regarding the role of protein methylation and demethylation in regulating NR mediated transcription.

ORIGINAL RESEARCH:

Wilbert Zwart, Mariska Rondaij, Kees Jalink, Z. Dave Sharp, Michael A. Mancini, Jacques Neefjes, and Rob Michalides

Resistance to Antiestrogen Arzoxifene Is Mediated by Overexpression of Cyclin D1
Mol Endocrinol 2009 23: 1335-1345, doi:10.1210/me.2008-0268 [Abstract] [Full Text] [PDF] [Supplemental Data]  
Overexpression of cyclin D1 alters the conformation of ER in the presence of arzoxifene, leading to its conversion from an antagonist to an agonist.

Carol D. Curtis, Daniel L. Thorngren, Yvonne S. Ziegler, Ali Sarkeshik, John R. Yates, and Ann M. Nardulli

Apurinic/Apyrimidinic Endonuclease 1 Alters Estrogen Receptor Activity and Estrogen-Responsive Gene Expression
Mol Endocrinol 2009 23: 1346-1359, doi:10.1210/me.2009-0093 [Abstract] [Full Text] [PDF]  
Redox factor 1/apurinic endonuclease-1 (Ape1/Ref-1) interacts with ER, associates with endogenous gene regions involved in conferring estrogen responsiveness, and influences estrogen-responsive gene expression.

Jyotsna B. Pippal, Yizhou Yao, Fraser M. Rogerson, and Peter J. Fuller

Structural and Functional Characterization of the Interdomain Interaction in the Mineralocorticoid Receptor
Mol Endocrinol 2009 23: 1360-1370, doi:10.1210/me.2009-0032 [Abstract] [Full Text] [PDF] [Supplemental Data]  
The ligand-specific dependence of the MR N/C-interaction may contribute to its differential activation in vivo.

Matthew D. Jonsen, Dawn L. Duval, and Arthur Gutierrez-Hartmann

The 26-Amino Acid ß-Motif of the Pit-1ß Transcription Factor Is a Dominant and Independent Repressor Domain
Mol Endocrinol 2009 23: 1371-1384, doi:10.1210/me.2008-0137 [Abstract] [Full Text] [PDF] [Supplemental Data]  
The Pit-1 ß-domain functions as a dominant, transferable repressor motif possessing protein context and DNA context dependent and independent activity

Daniel E. Frigo, Andrea B. Sherk, Bryan M. Wittmann, John D. Norris, Qianben Wang, James D. Joseph, Aidan P. Toner, Myles Brown, and Donald P. McDonnell

Induction of Krüppel-Like Factor 5 Expression by Androgens Results in Increased CXCR4-Dependent Migration of Prostate Cancer Cells in Vitro
Mol Endocrinol 2009 23: 1385-1396, doi:10.1210/me.2009-0010 [Abstract] [Full Text] [PDF] [Supplemental Data]  
Androgens increase the migration of prostate cancer cells towards CXCL12-rich environments by increasing CXCR4 levels through the direct AR-mediated expression of the transcription factor KLF5.

Xuegong Zhu, Sylvia L. Asa, and Shereen Ezzat

Histone-Acetylated Control of Fibroblast Growth Factor Receptor 2 Intron 2 Polymorphisms and Isoform Splicing in Breast Cancer
Mol Endocrinol 2009 23: 1397-1405, doi:10.1210/me.2009-0071 [Abstract] [Full Text] [PDF]  
We show that breast cancer intron 2 FGFR2 polymorphisms alter histone modifications modulating access to transcription factor binding sites that can drive gene expression.

Lowenna J. Holt, Ruth J. Lyons, Ashleigh S. Ryan, Susan M. Beale, Andrew Ward, Gregory J. Cooney, and Roger J. Daly

Dual Ablation of Grb10 and Grb14 in Mice Reveals Their Combined Role in Regulation of Insulin Signaling and Glucose Homeostasis
Mol Endocrinol 2009 23: 1406-1414, doi:10.1210/me.2008-0386 [Abstract] [Full Text] [PDF]  
Dual ablation of Grb10 and Grb14 does not enhance insulin signaling beyond that observed in the single knock-outs, but protects from high-fat diet-induced glucose intolerance.

Paul J. Brighton, John McDonald, Anthony H. Taylor, R. A. John Challiss, David G. Lambert, Justin C. Konje, and Jonathon M. Willets

Characterization of Anandamide-Stimulated Cannabinoid Receptor Signaling in Human ULTR Myometrial Smooth Muscle Cells
Mol Endocrinol 2009 23: 1415-1427, doi:10.1210/me.2009-0097 [Abstract] [Full Text] [PDF]  
The endocannabinoid anandamide activates endogenous cannabinoid type-1 receptors in myometrial cells to inhibit adenylate cyclase and activate ERK through a G_i/o-, phosphoinositide-3-kinase- and Src-kinase-dependent pathway.

Wu-xiang Liao, Lin Feng, Honghai Zhang, Jing Zheng, Thomas R. Moore, and Dong-bao Chen

Compartmentalizing VEGF-Induced ERK2/1 Signaling in Placental Artery Endothelial Cell Caveolae: A Paradoxical Role of Caveolin-1 in Placental Angiogenesis in Vitro
Mol Endocrinol 2009 23: 1428-1444, doi:10.1210/me.2008-0475 [Abstract] [Full Text] [PDF] [Supplemental Data]  
Caveolin-1 plays a paradoxical role in the VEGF-regulated in vitro placental angiogenesis via compartmentalizing the ERK2/1 signaling module in placental artery endothelial caveolae.

Kumaran Sundaram, Joseph Senn, Sambandam Yuvaraj, D. Sudhaker Rao, and Sakamuri V. Reddy

FGF-2 Stimulation of RANK Ligand Expression in Paget’s Disease of Bone
Mol Endocrinol 2009 23: 1445-1454, doi:10.1210/me.2009-0078 [Abstract] [Full Text] [PDF]  
STAT-1 is a downstream effector of fibroblast growth factor-2 (FGF-2) signaling and elevated levels of FGF-2 stimulates RANK ligand expression in Paget’s disease of bone.

Liming Wang, Diane Gesty-Palmer, Timothy A. Fields, and Robert F. Spurney

Inhibition of WNT Signaling by G Protein-Coupled Receptor (GPCR) Kinase 2 (GRK2)
Mol Endocrinol 2009 23: 1455-1465, doi:10.1210/me.2009-0084 [Abstract] [Full Text] [PDF] [Supplemental Data]  
GRK2 inhibits Wnt/β-catenin canonical signaling by mechanisms requiring GRK2 enzymatic activity and a protein-protein interaction between GRK2 and the adenomatous polyposis coli (APC) protein.

Brian W. Jones and Patricia M. Hinkle

Subcellular Trafficking of the TRH Receptor: Effect of Phosphorylation
Mol Endocrinol 2009 23: 1466-1478, doi:10.1210/me.2009-0119 [Abstract] [Full Text] [PDF] [Supplemental Data]  
Dephosphorylated TRH receptor recycles slowly via Rab4 while plasma membrane receptors are more rapidly repopulated from an intracellular pool.

Regina Hanstein, Jacqueline Trotter, Christian Behl, and Angela B. Clement

Increased Connexin 43 Expression as a Potential Mediator of the Neuroprotective Activity of the Corticotropin-Releasing Hormone
Mol Endocrinol 2009 23: 1479-1493, doi:10.1210/me.2009-0022 [Abstract] [Full Text] [PDF] [Supplemental Data]  
CRH-induced upregulation of Cx43 correlates with its neuroprotecive effects whereas inhibition of gap junction communication counteracts CRH-induced neuroprotection.

Vanessa Niederkinkhaus, Romy Marx, Gerd Hoffmann, and Irmgard D. Dietzel

Thyroid Hormone (T₃)-Induced Up-Regulation of Voltage-Activated Sodium Current in Cultured Postnatal Hippocampal Neurons Requires Secretion of Soluble Factors from Glial Cells
Mol Endocrinol 2009 23: 1494-1504, doi:10.1210/me.2009-0132 [Abstract] [Full Text] [PDF]  
Upregulation of neuronal voltage-activated Na⁺ currents by T3 requires secretion of soluble factors from cocultured satellite cells, is mimicked by bFGF and blocked by anti-bFGF antibodies.

RESEARCH RESOURCE:

Shiguang Liu, Wen Tang, Jianwen Fang, Jinyu Ren, Hua Li, Zhousheng Xiao, and L. D. Quarles

Novel Regulators of Fgf23 Expression and Mineralization in Hyp Bone
Mol Endocrinol 2009 23: 1505-1518, doi:10.1210/me.2009-0085 [Abstract] [Full Text] [PDF] [Supplemental Data]  
Gene expression array analysis of Hyp bone identifies novel Phex-dependent pathways associated with elevated Fgf23 expression, altered proteolysis and abnormal matrix mineralization.

TRANSLATIONAL HIGHLIGHTS FROM JCEM:

Harold S. Sacks, John N. Fain, Ben Holman, Paramjeet Cheema, Aron Chary, Frank Parks, James Karas, Robert Optican, Suleiman W. Bahouth, Edward Garrett, Rodney Y. Wolf, Russell A. Carter, Todd Robbins, David Wolford, and Joseph Samaha

Uncoupling Protein-1 and Related Messenger Ribonucleic Acids in Human Epicardial and Other Adipose Tissues: Epicardial Fat Functioning as Brown Fat
Mol Endocrinol 2009 23: 1519-1520 [Full Text] [PDF]  

Sonia Fernández-Veledo, Rocio Vila-Bedmar, Iria Nieto-Vazquez, and Margarita Lorenzo

c-Jun N-Terminal Kinase 1/2 Activation by Tumor Necrosis Factor- Induces Insulin Resistance In Human Visceral But Not Subcutaneous Adipocytes: Reversal by Liver X Receptor Agonists
Mol Endocrinol 2009 23: 1519 [Full Text] [PDF]  

Rosemary A. L. Bayne, Sharon L. Eddie, Craig S. Collins, Andrew J. Childs, Henry N. Jabbour, and Richard A. Anderson

Prostaglandin E₂ as a Regulator of Germ Cells during Ovarian Development
Mol Endocrinol 2009 23: 1520-1521 [Full Text] [PDF]  

Juan J. Chillarón, Alberto Goday, Juana A. Flores-Le-Roux, David Benaiges, María J. Carrera, Jaume Puig, Juan F. Cano-Pérez, and Juan Pedro-Botet

Estimated Glucose Disposal Rate in Assessment of the Metabolic Syndrome and Microvascular Complications in Patients with Type 1 Diabetes
Mol Endocrinol 2009 23: 1520 [Full Text] [PDF]  

Ronnie Minnaard, Patrick Schrauwen, Gert Schaart, Johanna A. Jorgensen, Ellen Lenaers, Marco Mensink, and Matthijs K.C. Hesselink

Adipocyte Differentiation-Related Protein and OXPAT in Rat and Human Skeletal Muscle: Involvement in Lipid Accumulation and Type 2 Diabetes Mellitus
Mol Endocrinol 2009 23: 1521 [Full Text] [PDF]  

ANNOUNCEMENTS AND RESOURCES:

Corrigenda
Mol Endocrinol 2009 23: 1522 [Full Text] [PDF]  

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