SPECIAL FEATURE:

Hei Sook Sul

Minireview: Pref-1: Role in Adipogenesis and Mesenchymal Cell Fate
Mol Endocrinol 2009 23: 1717-1725, doi:10.1210/me.2009-0160 [Abstract] [Full Text] [PDF]  
Pref-1 activates MEK/ERK and induces Sox9 expression thereby causing inhibition of adipocyte differentiation, promotion of chondrogenic commitment, inhibition of chondrocyte maturation and osteoblast differentiation.

ORIGINAL RESEARCH:

Andrea Kotitschke, Hanél Sadie-Van Gijsen, Chanel Avenant, Sandra Fernandes, and Janet P. Hapgood

Genomic and Nongenomic Cross Talk between the Gonadotropin-Releasing Hormone Receptor and Glucocorticoid Receptor Signaling Pathways
Mol Endocrinol 2009 23: 1726-1745, doi:10.1210/me.2008-0462 [Abstract] [Full Text] [PDF]  
GnRH activates the unliganded glucocorticoid receptor (GR) via GnRHR-dependent GR phosphorylation to result in GR-mediated upregulation of transcription. Furthermore, GnRH triggers a synergistic transcriptional response with ligand-bound receptor.

Hyereen Kang, Yoon Suk Kim, and Jesang Ko

A Novel Isoform of Human LZIP Negatively Regulates the Transactivation of the Glucocorticoid Receptor
Mol Endocrinol 2009 23: 1746-1757, doi:10.1210/me.2009-0009 [Abstract] [Full Text] [PDF]  
A novel isoform of human LZIP functions as a negative regulator in glucocorticoid-induced transactivation of the glucocorticoid receptor by recruitment and activation of histone deacetylases.

Ivan H. Chan and Martin L. Privalsky

Isoform-Specific Transcriptional Activity of Overlapping Target Genes that Respond to Thyroid Hormone Receptors 1 and β1
Mol Endocrinol 2009 23: 1758-1775, doi:10.1210/me.2009-0025 [Abstract] [Full Text] [PDF] [Supplemental Data]  
Thyroid hormone receptors 1 and β1 regulate overlapping panels of target genes, yet mediate distinct levels of transcriptional activity on any given target gene.

Dennis J. van de Wijngaart, Hendrikus J. Dubbink, Michel Molier, Carola de Vos, Jan Trapman, and Guido Jenster

Functional Screening of FxxLF-Like Peptide Motifs Identifies SMARCD1/BAF60a as an Androgen Receptor Cofactor that Modulates TMPRSS2 Expression
Mol Endocrinol 2009 23: 1776-1786, doi:10.1210/me.2008-0280 [Abstract] [Full Text] [PDF] [Supplemental Data]  
SWI/SNF subunit SMARCD1/BAF60a binds the androgen receptor via an FxxFF motif and plays a critical role in the androgen-regulated expression of TMPRSS2.

Yau-Sheng Tsai, Pei-Jane Tsai, Man-Jin Jiang, Ting-Yu Chou, Avani Pendse, Hyung-Suk Kim, and Nobuyo Maeda

Decreased PPAR Expression Compromises Perigonadal-Specific Fat Deposition and Insulin Sensitivity
Mol Endocrinol 2009 23: 1787-1798, doi:10.1210/me.2009-0073 [Abstract] [Full Text] [PDF] [Supplemental Data]  
Higher than 30% normal PPARgamma gene expression is necessary to maintain mass and functionality of body fat, and insulin sensitivity in mice.

Emilio J. Laserna, M. Luz Valero, Libia Sanz, Manuel M. Sánchez del Pino, Juan J. Calvete, and Domingo Barettino

Proteomic Analysis of Phosphorylated Nuclear Proteins Underscores Novel Roles for Rapid Actions of Retinoic Acid in the Regulation of mRNA Splicing and Translation
Mol Endocrinol 2009 23: 1799-1814, doi:10.1210/me.2009-0165 [Abstract] [Full Text] [PDF]  
Treatment of neuroblastoma cells with RA leads to alteration of the regulation of premRNA splicing and mRNA translation, via the activation of signaling pathways.

Adele Vivacqua, Rosamaria Lappano, Paola De Marco, Diego Sisci, Saveria Aquila, Francesca De Amicis, Suzanne A. W. Fuqua, Sebastiano Andò, and Marcello Maggiolini

G Protein-Coupled Receptor 30 Expression Is Up-Regulated by EGF and TGF in Estrogen Receptor -Positive Cancer Cells
Mol Endocrinol 2009 23: 1815-1826, doi:10.1210/me.2009-0120 [Abstract] [Full Text] [PDF] [Supplemental Data]  
EGF and TGF generate a stimulatory network in estrogen-sensitive cancer cells up-regulating GPR30, which interacts with activated EGFR and ER.

Shun-Fu Chang, Ting-Kuo Chang, Hsin-Hsin Peng, Yi-Ting Yeh, Ding-Yu Lee, Chiuan-Ren Yeh, Jing Zhou, Cheng-Kung Cheng, Cheng Allen Chang, and Jeng-Jiann Chiu

BMP-4 Induction of Arrest and Differentiation of Osteoblast-Like Cells via p21^CIP1 and p27^KIP1 Regulation
Mol Endocrinol 2009 23: 1827-1838, doi:10.1210/me.2009-0143 [Abstract] [Full Text] [PDF] [Supplemental Data]  
ECM/β3 integrin/FAK/Shc and the downstream ERK2 are involved in BMP-4-induced G₀/G₁ arrest and hence differentiation in osteoblast-like cells through BMPRIA/Smad-inductions of p21^CIP1 and p27^KIP1.

X. O. Zhu, Z. Yang, C. M. Guo, X. T. Ni, J. N. Li, Y. C. Ge, L. Myatt, and K. Sun

Paradoxical Stimulation of Cyclooxygenase-2 Expression by Glucocorticoids via a Cyclic AMP Response Element in Human Amnion Fibroblasts
Mol Endocrinol 2009 23: 1839-1849, doi:10.1210/me.2009-0201 [Abstract] [Full Text] [PDF] [Supplemental Data]  
Cortisol induces COX-2 by increasing phosphorylated CREB via PKA or p38-MAPK and its binding to the CRE of the COX-2 gene in human amnion fibroblasts.

Masha Dobkin-Bekman, Michal Naidich, Liat Rahamim, Fiorenza Przedecki, Tal Almog, Stefan Lim, Philippa Melamed, Ping Liu, Thorsten Wohland, Zhong Yao, Rony Seger, and Zvi Naor

A Preformed Signaling Complex Mediates GnRH-Activated ERK Phosphorylation of Paxillin and FAK at Focal Adhesions in LβT2 Gonadotrope Cells
Mol Endocrinol 2009 23: 1850-1864, doi:10.1210/me.2008-0260 [Abstract] [Full Text] [PDF]  
A pre-formed signaling complex associated with the GnRH receptor sequesters activated ERK1/2 to phosphorylate FAK and paxillin at focal adhesions and regulates cell migration.

Lu Mei He, Daniel J. Sartori, Monica Teta, Lynn M. Opare-Addo, Matthew M. Rankin, Simon Y. Long, J. Alan Diehl, and Jake A. Kushner

Cyclin D2 Protein Stability Is Regulated in Pancreatic β-Cells
Mol Endocrinol 2009 23: 1865-1875, doi:10.1210/me.2009-0057 [Abstract] [Full Text] [PDF] [Supplemental Data]  
Cyclin D2 protein stability in pancreatic β-cells is regulated by signals that act via threonine 280.

Jay C. Strum, Jennifer H. Johnson, James Ward, Hongbo Xie, John Feild, Austin Hester, Alexander Alford, and K. Michelle Waters

MicroRNA 132 Regulates Nutritional Stress-Induced Chemokine Production through Repression of SirT1
Mol Endocrinol 2009 23: 1876-1884, doi:10.1210/me.2009-0117 [Abstract] [Full Text] [PDF] [Supplemental Data]  
miR-132 regulates chemokine production in human adipocytes through repression of SirT1 mediated deacetylation of NFB.

Fiona O'Mahony, Rodrigo Alzamora, Ho-Lam Chung, Warren Thomas, and Brian J. Harvey

Genomic Priming of the Antisecretory Response to Estrogen in Rat Distal Colon throughout the Estrous Cycle
Mol Endocrinol 2009 23: 1885-1899, doi:10.1210/me.2008-0248 [Abstract] [Full Text] [PDF]  
The study demonstrates an interdependent relationship between non-genomic and genomic levels of estrogen regulation of intestinal secretion.

Roopa L. Nalam, Claudia Andreu-Vieyra, Robert E. Braun, Haruhiko Akiyama, and Martin M. Matzuk

Retinoblastoma Protein Plays Multiple Essential Roles in the Terminal Differentiation of Sertoli Cells
Mol Endocrinol 2009 23: 1900-1913, doi:10.1210/me.2009-0184 [Abstract] [Full Text] [PDF] [Supplemental Data]  
Conditional knockout of Rb in murine Sertoli cells results in irregular terminal differentiation, misregulation of known and novel RB-regulated genes, and infertility.

Rosana D. Meyer, Ekaterina V. Laz, Ting Su, and David J. Waxman

Male-Specific Hepatic Bcl6: Growth Hormone-Induced Block of Transcription Elongation in Females and Binding to Target Genes Inversely Coordinated with STAT5
Mol Endocrinol 2009 23: 1914-1926, doi:10.1210/me.2009-0242 [Abstract] [Full Text] [PDF] [Supplemental Data]  
Female-specific plasma GH profile blocks transcriptional elongation of male-specific rat hepatic Bcl6. Male plasma GH pulses inversely coordinate binding of Bcl6 and STAT5 to Socs2.

ANNOUNCEMENTS AND RESOURCES:

NIDDK Workshop on Circadian Rhythms and Metabolic Disease
Mol Endocrinol 2009 23: 1899 [Full Text] [PDF]  

RESEARCH RESOURCE:

Mei Jiang, Yunsheng Ma, Congcong Chen, Xuping Fu, Shu Yang, Xia Li, Guohua Yu, Yumin Mao, Yi Xie, and Yao Li

Androgen-Responsive Gene Database: Integrated Knowledge on Androgen-Responsive Genes
Mol Endocrinol 2009 23: 1927-1933, doi:10.1210/me.2009-0103 [Abstract] [Full Text] [PDF]  
Androgen Responsive Gene Database provides a unified gateway to storage, retrieval and update of information on androgen-regulated genes.

TRANSLATIONAL HIGHLIGHTS FROM JCEM:

C. M. Guo, X. O. Zhu, X. T. Ni, Z. Yang, L. Myatt, and K. Sun

Expression of Progesterone Receptor A form and Its Role in the Interaction of Progesterone with Cortisol on Cyclooxygenase-2 Expression in Amnionic Fibroblasts
Mol Endocrinol 2009 23: 1934-1935 [Full Text] [PDF]  

Mark S. Cooper and Paul M. Stewart

11β-Hydroxysteroid Dehydrogenase Type 1 and Its Role in the Hypothalamus-Pituitary-Adrenal Axis, Metabolic Syndrome, and Inflammation
Mol Endocrinol 2009 23: 1934 [Full Text] [PDF]  

Samantha Butts, Harold Riethman, Sarah Ratcliffe, Alka Shaunik, Christos Coutifaris, and Kurt Barnhart

Correlation of Telomere Length and Telomerase Activity with Occult Ovarian Insufficiency
Mol Endocrinol 2009 23: 1935 [Full Text] [PDF]  

Anna L. Mitchell, Heather J. Cordell, Rachel Soemedi, Kate Owen, Beate Skinningsrud, Anette Bøe Wolff, Martina Ericksen, Dag Undlien, Eystein Husebye, and Simon H. S. Pearce

Programmed Death Ligand 1 (PD-L1) Gene Variants Contribute to Autoimmune Addison’s Disease and Graves’ Disease Susceptibility
Mol Endocrinol 2009 23: 1935 [Full Text] [PDF]  

Irène Netchine, Salah Azzi, Muriel Houang, Danielle Seurin, Laurence Perin, Jean-Marc Ricort, Claudine Daubas, Christine Legay, Jan Mester, Robert Herich, François Godeau, and Yves Le Bouc

Partial Primary Deficiency of Insulin-Like Growth Factor (IGF)-I Activity Associated with IGF1 Mutation Demonstrates Its Critical Role in Growth and Brain Development
Mol Endocrinol 2009 23: 1936 [Full Text] [PDF]  

Feng-Tao Shi, Anthony P. Cheung, He-Feng Huang, and Peter C. K. Leung

Effects of Endogenous Growth Differentiation Factor 9 on Activin A-Induced Inhibin B Production in Human Granulosa-Lutein Cells
Mol Endocrinol 2009 23: 1936 [Full Text] [PDF]  

Ning Jin, Tianyun Jiang, D. Marc Rosen, Barry D. Nelkin, and Douglas W. Ball

Dual Inhibition of Mitogen-Activated Protein Kinase Kinase and Mammalian Target of Rapamycin in Differentiated and Anaplastic Thyroid Cancer
Mol Endocrinol 2009 23: 1937 [Full Text] [PDF]  

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