SPECIAL FEATURE:

David M. Lonard, Rakesh Kumar, and Bert W. O'Malley

Minireview: The SRC Family of Coactivators: An Entrée to Understanding a Subset of Polygenic Diseases?
Mol Endocrinol 2010 24: 279-285, doi:10.1210/me.2009-0276 [Abstract] [Full Text] [PDF]  
As integrators of signals from the environment capable of broadly coordinating cellular gene expression, SRC family coactivators are predicted to participate in polygenic disease states.

Heng-Yu Fan and JoAnne S. Richards

Minireview: Physiological and Pathological Actions of RAS in the Ovary
Mol Endocrinol 2010 24: 286-298, doi:10.1210/me.2009-0251 [Abstract] [Full Text] [PDF]  
Activation of RAS in the ovary exerts cell context specific effects leading to physiological (follicular ovulation and luteinization) and pathological (ovarian surface epithelial cancer) effects.

ORIGINAL RESEARCH:

William A. Alaynick, James M. Way, Stephanie A. Wilson, William G. Benson, Liming Pei, Michael Downes, Ruth Yu, Johan W. Jonker, Jason A. Holt, Deepak K. Rajpal, Hao Li, Joan Stuart, Ruth McPherson, Katja S. Remlinger, Ching-Yi Chang, Donald P. McDonnell, Ronald M. Evans, and Andrew N. Billin

ERR Regulates Cardiac, Gastric, and Renal Potassium Homeostasis
Mol Endocrinol 2010 24: 299-309, doi:10.1210/me.2009-0114 [Abstract] [Full Text] [PDF] [Supplemental Data]  
In addition to regulation of oxidative metabolism, ERR regulates ion homeostasis, especially potassium, in renal, gastric and cardiac tissues and appears to influence hypertension in mouse and human.

Geert van Loo, Mozes Sze, Nadia Bougarne, Jelle Praet, Conor Mc Guire, Andrea Ullrich, Guy Haegeman, Marco Prinz, Rudi Beyaert, and Karolien De Bosscher

Antiinflammatory Properties of a Plant-Derived Nonsteroidal, Dissociated Glucocorticoid Receptor Modulator in Experimental Autoimmune Encephalomyelitis
Mol Endocrinol 2010 24: 310-322, doi:10.1210/me.2009-0236 [Abstract] [Full Text] [PDF] [Supplemental Data]  
The study demonstrates the therapeutic potential of Compound A (CpdA), an anti-inflammatory Glucocorticoid Receptor modulator, in experimental autoimmune encephalomyelitis (EAE), an animal model of multiple sclerosis.

Marta Martin-Millan, Maria Almeida, Elena Ambrogini, Li Han, Haibo Zhao, Robert S. Weinstein, Robert L. Jilka, Charles A. O'Brien, and Stavros C. Manolagas

The Estrogen Receptor- in Osteoclasts Mediates the Protective Effects of Estrogens on Cancellous But Not Cortical Bone
Mol Endocrinol 2010 24: 323-334, doi:10.1210/me.2009-0354 [Abstract] [Full Text] [PDF]  
Attenuation of osteoclast apoptosis by a DNA-binding independent action of the ER accounts for the protective effects of estrogens on cancellous, but not cortical, bone.

Suzanne E. Wardell, Ramesh Narayanan, Nancy L. Weigel, and Dean P. Edwards

Partial Agonist Activity of the Progesterone Receptor Antagonist RU486 Mediated by an Amino-Terminal Domain Coactivator and Phosphorylation of Serine⁴⁰⁰
Mol Endocrinol 2010 24: 335-345, doi:10.1210/me.2008-0081 [Abstract] [Full Text] [PDF]  
This study demonstrates that conformational flexibility and site-specific phosphorylation of the amino-terminal domain of progesterone receptor are important determinants for cellular responses to different ligands.

Jamie Bonéy-Montoya, Yvonne S. Ziegler, Carol D. Curtis, Jonathan A. Montoya, and Ann M. Nardulli

Long-Range Transcriptional Control of Progesterone Receptor Gene Expression
Mol Endocrinol 2010 24: 346-358, doi:10.1210/me.2009-0429 [Abstract] [Full Text] [PDF]  
Estrogen receptor alpha and ligands alter interaction of proximal and distal gene regions to regulate progesterone receptor gene expression.

Julie M. Hall, Melissa A. Barhoover, Dmitri Kazmin, Donald P. McDonnell, William F. Greenlee, and Russell S. Thomas

Activation of the Aryl-Hydrocarbon Receptor Inhibits Invasive and Metastatic Features of Human Breast Cancer Cells and Promotes Breast Cancer Cell Differentiation
Mol Endocrinol 2010 24: 359-369, doi:10.1210/me.2009-0346 [Abstract] [Full Text] [PDF] [Supplemental Data]  
The AhR inhibits invasive properties and promotes differentiation of breast cancer cells; thus, the receptor represents a promising therapeutic target for human breast cancers.

Natalia Di Pietro, Valentine Panel, Schantel Hayes, Alessia Bagattin, Sunitha Meruvu, Assunta Pandolfi, Lynne Hugendubler, Geza Fejes-Tóth, Aniko Naray-Fejes-Tóth, and Elisabetta Mueller

Serum- and Glucocorticoid-Inducible Kinase 1 (SGK1) Regulates Adipocyte Differentiation via Forkhead Box O1
Mol Endocrinol 2010 24: 370-380, doi:10.1210/me.2009-0265 [Abstract] [Full Text] [PDF] [Supplemental Data]  
SGK1 is induced during adipogenesis in response to dexamethasone and modulates adipocytes differentiation through Foxo1’s phosphorylation and relocalization to the cytoplasm.

Jonathon T. Hill, Christina S. Chao, Keith R. Anderson, Fernanda Kaufman, Christopher W. Johnson, and Lori Sussel

Nkx2.2 Activates the Ghrelin Promoter in Pancreatic Islet Cells
Mol Endocrinol 2010 24: 381-390, doi:10.1210/me.2009-0360 [Abstract] [Full Text] [PDF] [Supplemental Data]  
Characterization of ghrelin promoter activity in the pancreas demonstrates that Nkx2.2 binds to and activates ghrelin transcription.

Sutapa Ray, Chang Lee, Tieying Hou, Kishor K. Bhakat, and Allan R. Brasier

Regulation of Signal Transducer and Activator of Transcription 3 Enhanceosome Formation by Apurinic/Apyrimidinic Endonuclease 1 in Hepatic Acute Phase Response
Mol Endocrinol 2010 24: 391-401, doi:10.1210/me.2009-0319 [Abstract] [Full Text] [PDF]  
STAT3-APE1 complex is required for stable chromatin association in the IL-6-induced hepatic acute phase response.

Yitzhak Reizel, Judith Elbaz, and Nava Dekel

Sustained Activity of the EGF Receptor Is an Absolute Requisite for LH-Induced Oocyte Maturation and Cumulus Expansion
Mol Endocrinol 2010 24: 402-411, doi:10.1210/me.2009-0267 [Abstract] [Full Text] [PDF] [Supplemental Data]  
A sustained activity of the EGFR is necessary to mediate LH-induced responses in the ovarian follicle such as ERK1/2 phosphorylation, oocyte maturation and cumulus expansion.

Marina Lasa, Beatriz Gil-Araujo, Marta Palafox, and Ana Aranda

Thyroid Hormone Antagonizes Tumor Necrosis Factor- Signaling in Pituitary Cells through the Induction of Dual Specificity Phosphatase 1
Mol Endocrinol 2010 24: 412-422, doi:10.1210/me.2009-0298 [Abstract] [Full Text] [PDF]  
Thyroid hormone inhibits TNF-alpha-mediated activation of both MAPK p38 and NF-B pathways by a mechanism requiring the induction of the DUSP1 phosphatase.

Ann R. Finch, Christopher J. Caunt, Stephen P. Armstrong, and Craig A. McArdle

Plasma Membrane Expression of Gonadotropin-Releasing Hormone Receptors: Regulation by Peptide and Nonpeptide Antagonists
Mol Endocrinol 2010 24: 423-435, doi:10.1210/me.2009-0343 [Abstract] [Full Text] [PDF]  
Non-peptide and peptide GnRH antagonists can both increase cell surface GnRH receptors but by different mechanisms, increasing trafficking to the surface or slowing internalization, respectively.

Florian Pöll, Diana Lehmann, Susann Illing, Mihaela Ginj, Stefan Jacobs, Amelie Lupp, Ralf Stumm, and Stefan Schulz

Pasireotide and Octreotide Stimulate Distinct Patterns of sst_2A Somatostatin Receptor Phosphorylation
Mol Endocrinol 2010 24: 436-446, doi:10.1210/me.2009-0315 [Abstract] [Full Text] [PDF] [Supplemental Data]  
Pasireotide and octreotide stimulate distinct patterns of sst2A somatostatin receptor phosphorylation, beta-arrestin trafficking and internalization.

Ankur K. Nagaraja, Chad J. Creighton, Zhifeng Yu, Huifeng Zhu, Preethi H. Gunaratne, Jeffrey G. Reid, Emuejevoke Olokpa, Hiroaki Itamochi, Naoto T. Ueno, Shannon M. Hawkins, Matthew L. Anderson, and Martin M. Matzuk

A Link between mir-100 and FRAP1/mTOR in Clear Cell Ovarian Cancer
Mol Endocrinol 2010 24: 447-463, doi:10.1210/me.2009-0295 [Abstract] [Full Text] [PDF] [Supplemental Data]  
Mir-100 is a candidate tumor suppressor microRNA that inhibits mTOR signaling and enhances sensitivity to the rapamycin analog RAD001 (everolimus) in clear cell ovarian cancer.

RESEARCH RESOURCE:

Jeremy A. Lavine, Philipp W. Raess, Dawn B. Davis, Mary E. Rabaglia, Brent K. Presley, Mark P. Keller, Margery C. Beinfeld, Alan S. Kopin, Christopher B. Newgard, and Alan D. Attie

Contamination with E1A-Positive Wild-Type Adenovirus Accounts for Species-Specific Stimulation of Islet Cell Proliferation by CCK: A Cautionary Note
Mol Endocrinol 2010 24: 464-467, doi:10.1210/me.2009-0384 [Abstract] [Full Text] [PDF] [Supplemental Data]  
Wild-type E1A-expressing adenovirus and not cholecystokinin stimulates mouse and human islet cell proliferation. Cholecystokinin and E1A both stimulate rat islet cell proliferation.

TRANSLATIONAL HIGHLIGHTS FROM JCEM:

K. Ma, C. S. Nunemaker, R. Wu, S. K. Chakrabarti, D. A. Taylor-Fishwick, and J. L. Nadler

12-Lipoxygenase Products Reduce Insulin Secretion and β-Cell Viability in Human Islets
Mol Endocrinol 2010 24: 468 [Full Text] [PDF]  

Ashis K. Mondal, Swapan K. Das, Giulia Baldini, Winston S. Chu, Neeraj K. Sharma, Oksana G. Hackney, Jianhua Zhao, Struan F. A. Grant, and Steven C. Elbein

Genotype and Tissue-Specific Effects on Alternative Splicing of the Transcription Factor 7-Like 2 Gene in Humans
Mol Endocrinol 2010 24: 468-469 [Full Text] [PDF]  

Francesco Pacifico, Elvira Crescenzi, Stefano Mellone, Alessio Iannetti, Nunzio Porrino, Domenico Liguoro, Fortunato Moscato, Michele Grieco, Silvestro Formisano, and Antonio Leonardi

Nuclear Factor-B Contributes to Anaplastic Thyroid Carcinomas through Up-Regulation of miR-146a
Mol Endocrinol 2010 24: 469 [Full Text] [PDF]  

Tassilo Kruis, Jürgen Klammt, Assimina Galli-Tsinopoulou, Tillmann Wallborn, Marina Schlicke, Eva Müller, Jürgen Kratzsch, Antje Körner, Rasha Odeh, Wieland Kiess, and Roland Pfäffle

Heterozygous Mutation within a Kinase-Conserved Motif of the Insulin-Like Growth Factor I Receptor Causes Intrauterine and Postnatal Growth Retardation
Mol Endocrinol 2010 24: 469-470 [Full Text] [PDF]  

Laurence Ladriere, Mariana Igoillo-Esteve, Daniel A. Cunha, Jean-Pierre Brion, Marco Bugliani, Piero Marchetti, Décio L. Eizirik, and Miriam Cnop

Enhanced Signaling Downstream of Ribonucleic Acid-Dependent Protein Kinase-Like Kinase Potentiates Lipotoxic Endoplasmic Reticulum Stress in Human Islets
Mol Endocrinol 2010 24: 470 [Full Text] [PDF]  

ANNOUNCEMENTS AND RESOURCES:

Erratum
Mol Endocrinol 2010 24: 471 [Full Text] [PDF]  

Retraction
Mol Endocrinol 2010 24: 472 [Full Text] [PDF]  

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