SPECIAL FEATURE:

Carole R. Mendelson

Minireview: Fetal-Maternal Hormonal Signaling in Pregnancy and Labor
Mol Endocrinol 2009 23: 947-954, doi:10.1210/me.2009-0016 [Abstract] [Full Text] [PDF]  
Uterine quiescence throughout pregnancy and its increased contractility at term are regulated by a complex interplay of pro- and anti-inflammatory signals between fetus and mother.

ORIGINAL RESEARCH:

Bonnie J. Deroo, Karina F. Rodriguez, John F. Couse, Katherine J. Hamilton, Jennifer B. Collins, Sherry F. Grissom, and Kenneth S. Korach

Estrogen Receptor β Is Required for Optimal cAMP Production in Mouse Granulosa Cells
Mol Endocrinol 2009 23: 955-965, doi:10.1210/me.2008-0213 [Abstract] [Full Text] [PDF]  
Loss of ER-beta attenuates cAMP accumulation in gonadotropin- or forskolin-stimulated mouse granulosa cells

Geun Hyang Kim, Keunhee Park, Seon-Yong Yeom, Kyung Jin Lee, Gukhan Kim, Jesang Ko, Dong-Kwon Rhee, Young Hoon Kim, Hye Kyung Lee, Hae Won Kim, Goo Taeg Oh, Ki-Up Lee, Jae W. Lee, and Seung-Whan Kim

Characterization of ASC-2 as an Antiatherogenic Transcriptional Coactivator of Liver X Receptors in Macrophages
Mol Endocrinol 2009 23: 966-974, doi:10.1210/me.2008-0308 [Abstract] [Full Text] [PDF]  
Suppression of the LXR-specific activity of ASC-2 results in accelerated atherogenesis, suggesting that ASC-2 is an anti-atherogenic coactivator of LXRs in macrophages.

Francine M. Gregoire, Fang Zhang, Holly J. Clarke, Thomas A. Gustafson, Dorothy D. Sears, Svetlana Favelyukis, James Lenhard, Dennis Rentzeperis, L. Edward Clemens, Yi Mu, and Brian E. Lavan

MBX-102/JNJ39659100, a Novel Peroxisome Proliferator-Activated Receptor-Ligand with Weak Transactivation Activity Retains Antidiabetic Properties in the Absence of Weight Gain and Edema
Mol Endocrinol 2009 23: 975-988, doi:10.1210/me.2008-0473 [Abstract] [Full Text] [PDF] [Supplemental Data]  
MBX-102/JNJ39659100 is a selective PPAR- modulator that displays weak transactivation but robust transrepression activity and exhibits therapeutic activity without the classic PPAR- side effects.

Britta M. Jacobsen, Purevsuren Jambal, Stephanie A. Schittone, and Kathryn B. Horwitz

ALU Repeats in Promoters Are Position-Dependent Co-Response Elements (coRE) that Enhance or Repress Transcription by Dimeric and Monomeric Progesterone Receptors
Mol Endocrinol 2009 23: 989-1000, doi:10.1210/me.2009-0048 [Abstract] [Full Text] [PDF] [Supplemental Data]  
ALU repeats are co-response elements (coRE) that enhance or repress transcription mediated by dimeric and monomeric progesterone receptors from imperfect PREs or PRE half sites.

Pankaj Lamba, Jérôme Fortin, Stella Tran, Ying Wang, and Daniel J. Bernard

A Novel Role for the Forkhead Transcription Factor FOXL2 in Activin A-Regulated Follicle-Stimulating Hormone β Subunit Transcription
Mol Endocrinol 2009 23: 1001-1013, doi:10.1210/me.2008-0324 [Abstract] [Full Text] [PDF] [Supplemental Data]  
The forkhead transcription factor FOXL2 binds to distinct and conserved elements in the proximal FSHbeta subunit gene promoter, mediating activin induction in species-specific fashion.

Jing Liu, Colin D. MacCalman, Yan-ling Wang, and Peter C. K. Leung

Promotion of Human Trophoblasts Invasion by Gonadotropin-Releasing Hormone (GnRH) I and GnRH II via Distinct Signaling Pathways
Mol Endocrinol 2009 23: 1014-1021, doi:10.1210/me.2008-0451 [Abstract] [Full Text] [PDF]  
GnRH I and II facilitate human trophoblasts invasion via PKC and MAPK cascades, with the effects of GnRH II dependent upon activation of the EGF receptor.

Constance M. Grafer, Robin Thomas, Litsa Lambrakos, Ignacio Montoya, Sheryl White, and Lisa M. Halvorson

GnRH Stimulates Expression of PACAP in the Pituitary Gonadotropes via Both the PKA and PKC Signaling Systems
Mol Endocrinol 2009 23: 1022-1032, doi:10.1210/me.2008-0477 [Abstract] [Full Text] [PDF] [Supplemental Data]  
GnRH stimulates pituitary PACAP gene expression via multiple signaling pathways acting on two CRE/AP-1 sites in the proximal gene promoter.

Ezra Wiater, Kathy A. Lewis, Cynthia Donaldson, Joan Vaughan, Louise Bilezikjian, and Wylie Vale

Endogenous Betaglycan Is Essential for High-Potency Inhibin Antagonism in Gonadotropes
Mol Endocrinol 2009 23: 1033-1042, doi:10.1210/me.2009-0021 [Abstract] [Full Text] [PDF]  
Knockdown and immunoneutralization of the putative inhibin co-receptor betaglycan establishes that betaglycan is necessary for inhibin antagonism of activin induced FSH release in gonadotropes.

Diana Goenaga, Cornelia Hampe, Nadège Carré, Katia Cailliau, Edith Browaeys-Poly, Dominique Perdereau, Lowenna J. Holt, Roger J. Daly, Jean Girard, Isabelle Broutin, Tarik Issad, and Anne-Françoise Burnol

Molecular Determinants of Grb14-Mediated Inhibition of Insulin Signaling
Mol Endocrinol 2009 23: 1043-1051, doi:10.1210/me.2008-0360 [Abstract] [Full Text] [PDF] [Supplemental Data]  
Grb14 regulates insulin signaling and action affecting both insulin receptor binding and interfering with downstream pathways, including PDK1.

Jeffrey A. Quinn, C. Thomas Graeber, A. Raymond Frackelton, Jr., Minsoo Kim, Jean E. Schwarzbauer, and Edward J. Filardo

Coordinate Regulation of Estrogen-Mediated Fibronectin Matrix Assembly and Epidermal Growth Factor Receptor Transactivation by the G Protein-Coupled Receptor, GPR30
Mol Endocrinol 2009 23: 1052-1064, doi:10.1210/me.2008-0262 [Abstract] [Full Text] [PDF] [Supplemental Data]  
GPR30 transactivates the epidermal growth factor receptor in human breast cancer cells as a consequence of integrin 5β1-mediated fibronectin matrix assembly.

Leah Rider, Jing Tao, Stacy Snyder, Brittany Brinley, Jiayun Lu, and Maria Diakonova

Adapter Protein SH2B1β Cross-Links Actin Filaments and Regulates Actin Cytoskeleton
Mol Endocrinol 2009 23: 1065-1076, doi:10.1210/me.2008-0428 [Abstract] [Full Text] [PDF]  
Adapter protein SH2B1β directly binds to and cross-links actin filaments that lead to modulation of actin cytoskleton in response to JAK2 activation.

Travis J. Maures, Linyi Chen, and Christin Carter-Su

Nucleocytoplasmic Shuttling of the Adapter Protein SH2B1β (SH2-Bβ) Is Required for Nerve Growth Factor (NGF)-Dependent Neurite Outgrowth and Enhancement of Expression of a Subset of NGF-Responsive Genes
Mol Endocrinol 2009 23: 1077-1091, doi:10.1210/me.2009-0011 [Abstract] [Full Text] [PDF]  
SH2B1β requires access to both cytoplasmic and nuclear compartments to enhance NGF-induced gene transcription and neurite outgrowth.

Stuart P. Bliss, Andrew Miller, Amy M. Navratil, JianJun Xie, Sean P. McDonough, Patricia J. Fisher, Gary E. Landreth, and Mark S. Roberson

ERK Signaling in the Pituitary Is Required for Female But Not Male Fertility
Mol Endocrinol 2009 23: 1092-1101, doi:10.1210/me.2009-0030 [Abstract] [Full Text] [PDF]  
Genetic ablation of the ERK signaling pathway in pituitary gonadotropes leads to infertility in female but not male mice.

Damiana Giacomini, Marcelo Páez-Pereda, Johanna Stalla, Günter K. Stalla, and Eduardo Arzt

Molecular Interaction of BMP-4, TGF-β, and Estrogens in Lactotrophs: Impact on the PRL Promoter
Mol Endocrinol 2009 23: 1102-1114, doi:10.1210/me.2008-0425 [Abstract] [Full Text] [PDF]  
This study examines the regulatory interaction of BMP-4 and Estrogens on the PRL promoter and identifies the region for binding of BMP-4 specific Smad proteins.

Elissa White, Jennifer McKenna, Alice Cavanaugh, and Gerda E. Breitwieser

Pharmacochaperone-Mediated Rescue of Calcium-Sensing Receptor Loss-of-Function Mutants
Mol Endocrinol 2009 23: 1115-1123, doi:10.1210/me.2009-0041 [Abstract] [Full Text] [PDF]  
This study establishes approaches to characterize the trafficking defects of loss-of-function CaSR mutants, and the likelihood of "rescue" by the pharmacochaperone NPS R-568.

TRANSLATIONAL HIGHLIGHTS FROM JCEM:

John J. Peluso, Xiufang Liu, Anna Gawkowska, and Erika Johnston-MacAnanny

Progesterone Activates a Progesterone Receptor Membrane Component 1-Dependent Mechanism That Promotes Human Granulosa/Luteal Cell Survival But Not Progesterone Secretion
Mol Endocrinol 2009 23: 1124-1125 [Full Text] [PDF]  

Margrit Urbanek, Geetha Nampiaparampil, Janine D'Souza, Elizabeth Sefton, Christine Ackerman, Richard S. Legro, and Andrea Dunaif

The Role of Genetic Variation in the Lamin A/C Gene in the Etiology of Polycystic Ovary Syndrome
Mol Endocrinol 2009 23: 1124 [Full Text] [PDF]  

Marcela Julio-Pieper, Patricia Lozada, Veronica Tapia, Margarita Vega, Cristián Miranda, David Vantman, Sergio R. Ojeda, and Carmen Romero

Nerve Growth Factor Induces Vascular Endothelial Growth Factor Expression in Granulosa Cells via a trkA Receptor/Mitogen-Activated Protein Kinase-Extracellularly Regulated Kinase 2-Dependent Pathway
Mol Endocrinol 2009 23: 1125 [Full Text] [PDF]  

Yung Ming Lin, Chia Ling Chung, and Yu Sheng Cheng

Posttranscriptional Regulation of CDC25A by BOLL Is a Conserved Fertility Mechanism Essential for Human Spermatogenesis
Mol Endocrinol 2009 23: 1125 [Full Text] [PDF]  

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